Levels of tumour necrosis factor‐α and IL‐1α in newly diagnosed and multidrug resistant tuberculosis

Çağatay, Tülin; Kıran, Bayram; Yurt, Sibel; Gulbaran, Ziya; Koşar, Filiz; Çağatay, Penbe

doi:10.1111/j.1440-1843.2005.00711.x

Cited by 16 publications

(16 citation statements)

References 14 publications

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“…The increasing incidence of MDR-TB induces public health and treatment problems. Although the exact mechanism of developing MDR-TB remains to be elucidated, MDR-TB patients show an impaired production of the cytokines from peripheral blood cells or circulating sera including TNF-α, IL-1 and IL-12 [16,17,18]. We found reduced TNF-α levels in MDR-TB compared with non-MDR-TB patients, which agrees with other results [16,17,18].…”

Section: Discussionsupporting

confidence: 90%

“…Although the exact mechanism of developing MDR-TB remains to be elucidated, MDR-TB patients show an impaired production of the cytokines from peripheral blood cells or circulating sera including TNF-α, IL-1 and IL-12 [16,17,18]. We found reduced TNF-α levels in MDR-TB compared with non-MDR-TB patients, which agrees with other results [16,17,18]. TNF-α increases early in the disease and contributes to the elimination of mycobacteria including granuloma formation [3].…”

Section: Discussionmentioning

confidence: 99%

“…Neutralization of IL-10 increases the TNF-α production by peripheral blood cells in MDR-TB patients and in healthy controls [16]. These observations suggest that reduced TNF-α release may represent a depression of host immune defenses important in determining TB outcome since MDR-TB induces a depression of CD4+ T lymphocyte numbers [18]. Indeed, in the present study, low TNF-α but a high tendency of IL-10 levels was observed in MDR-TB compared with non-MDR-TB patients, although the significance was found only in TNF-α.…”

Section: Discussionmentioning

confidence: 99%

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Tumor Necrosis Factor-Alpha and Interleukin-10 in Whole Blood Is Associated with Disease Progression in Pulmonary Mulitdrug-Resistant Tuberculosis Patients

Eum¹,

Jeon²,

Min³

et al. 2008

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Background: Cytokine production profiles may reflect the clinical pictures of patients with tuberculosis (TB). Objective: We examined the relationship between cytokine levels and clinical parameters indicating the state of disease in active pulmonary TB patients. Methods: We measured interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin (IL)-10 levels in whole blood after stimulation with culture filtrate protein of Mycobacterium tuberculosis in 33 multi-drug resistant (MDR)-TB and 51 non-MDR-TB patients. Results: No significant difference was found in IFN-γ production between non-MDR-TB and MDR-TB patients, but there was a marked reduction in TNF-α production in MDR-TB patients accompanied by a moderate increase in IL-10 levels. In contrast, the presence of cavity was associated with a significant increase in IFN-γ, whereas no difference in TNF-α between the cavity and non-cavity group was observed. Those who have TB lesions in the left lung showed lower levels of IFN-γ and TNF-α and higher IL-10 levels than the patients with lesions on the right side. IFN-γ levels were significantly increased in those with moderate or advanced lesions compared with patients with mild lesions. TNF-α and IL-10 levels did not change with disease severity. The number of M. tuberculosis bacilli in sputum was closely associated with TNF-α levels. The patient group with high value (+++) of sputum culture acid-fast bacilli produced significantly reduced levels of TNF-α compared with medium (++) and low (+) values. Conclusion: These findings suggest that IFN-γ, TNF-α or IL-10 production patterns in whole blood are associated with disease progression in active pulmonary TB.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Tumor Necrosis Factor-Alpha and Interleukin-10 in Whole Blood Is Associated with Disease Progression in Pulmonary Mulitdrug-Resistant Tuberculosis Patients

Eum¹,

Jeon²,

Min³

et al. 2008

Respiration

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“…While it is difficult to make comparisons between absolute levels of plasma markers in different studies, it is interesting to note that IP-10 levels in plasma from our MDR patients described here were considerably lower than those reported in similar studies conducted in DS-TB patients [11, 20, 30, 54]. One possible explanation for these discrepancies may be related to the suppression of Th1 responses previously reported in association with MDR-TB [12, 13, 56, 57]. A large proportion (92%) of the patients in our study had a previous history of treatment for TB.…”

Section: Discussioncontrasting

confidence: 56%

“…However, the majority of these studies have been conducted in patients with DS-TB, and the results may not be generalizable to MDR-TB cases. Several reports have described lower levels of Th1 cytokines [12–14] and higher numbers of T regulatory (Treg) cells [15–17] in peripheral blood from MDR, compared to DS, TB patients. The trend towards greater immune suppression in MDR-TB may be related to a longer duration of disease and more extensive lung damage, as suggested by the recovery of cell mediated immunity following pulmonary resection to remove severely diseased tissue [18].…”

Section: Introductionmentioning

confidence: 99%

A combination of baseline plasma immune markers can predict therapeutic response in multidrug resistant tuberculosis

et al. 2017

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ObjectiveTo identify plasma markers predictive of therapeutic response in patients with multidrug resistant tuberculosis (MDR-TB).MethodsFifty HIV-negative patients with active pulmonary MDR-TB were analysed for six soluble analytes in plasma at the time of initiating treatment (baseline) and over six months thereafter. Patients were identified as sputum culture positive or negative at baseline. Culture positive patients were further stratified by the median time to sputum culture conversion (SCC) as fast responders (< 76 days) or slow responders (≥ 76 days). Chest X-ray scores, body mass index, and sputum smear microscopy results were obtained at baseline.ResultsUnsupervised hierarchical clustering revealed that baseline plasma levels of IP-10/CXCL10, VEGF-A, SAA and CRP could distinguish sputum culture and cavitation status of patients. Among patients who were culture positive at baseline, there were significant positive correlations between plasma levels of CRP, SAA, VEGF-A, sIL-2Rα/CD40, and IP-10 and delayed SCC. Using linear discriminant analysis (LDA) and Receiver Operating Curves (ROC), we showed that a combination of MCP-1/CCL2, IP-10, sIL-2Rα, SAA, CRP and AFB smear could distinguish fast from slow responders and were predictive of delayed SCC with high sensitivity and specificity.ConclusionPlasma levels of specific chemokines and inflammatory markers measured before MDR-TB treatment are candidate predictive markers of delayed SCC. These findings require validation in a larger study.

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Alterations in the peripheral blood B cell subpopulations of multidrug-resistant tuberculosis patients

et al. 2013

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The function of B cells in the immune response against Mycobacterium tuberculosis (Mtb) is still regarded as secondary, although major findings in mouse models of tuberculosis (TB) support their participation as regulators and antibody producers. However, studies in cohorts of TB or multidrug-resistant TB (MDR-TB) patients have failed to clearly identify changes in the circulating B cell pool. Therefore, in the present study we aimed at identifying alterations in the different B cell subpopulations in peripheral blood samples of HIV-negative pulmonary MDR-TB patients when compared to healthy donors. The data show, for the first time, that MDR-TB patients, similarly to what has been observed in other chronic inflammatory diseases, have a much lower frequency of peripheral blood unswitched IgD(+)CD27(+) memory B cells. Equally novel are the findings that in MDR-TB patients there is a reduction in the circulating plasma cell pool and that in MDR-TB there is an increased frequency of circulating type 1 transitional IgD(+)CD38(++), CD69(+) and TLR9(+) B cells. These results document disease-related shifts in peripheral blood B cell subsets in MDR-TB and suggest that such changes should be taken into account when designing new strategies to boost the cellular and humoral immune response against Mtb.

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Levels of tumour necrosis factor‐α and IL‐1α in newly diagnosed and multidrug resistant tuberculosis

Abstract: The lower levels of cytokines and numbers of T helper lymphocytes in MDR-TB compared with N-TB implies that the immune profiles of the two groups are different, and may be important in the natural history of the disease.

Cited by 16 publications

References 14 publications

Tumor Necrosis Factor-Alpha and Interleukin-10 in Whole Blood Is Associated with Disease Progression in Pulmonary Mulitdrug-Resistant Tuberculosis Patients

Tumor Necrosis Factor-Alpha and Interleukin-10 in Whole Blood Is Associated with Disease Progression in Pulmonary Mulitdrug-Resistant Tuberculosis Patients

A combination of baseline plasma immune markers can predict therapeutic response in multidrug resistant tuberculosis

Alterations in the peripheral blood B cell subpopulations of multidrug-resistant tuberculosis patients

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