Levels, profiles and dietary sources of hydroxylated PCBs and hydroxylated and methoxylated PBDEs in Japanese women serum samples

Haraguchi, Koichi; Ito, Yoshiko; Takagi, Masae; Fujii, Yukiko; Harada, Kouji H.; Koizumi, Akio

doi:10.1016/j.envint.2016.08.022

Cited by 36 publications

(12 citation statements)

References 57 publications

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“…BDE209,207,47,206,197,183 were the primary congeners in the serum. Because of its lower bioavailability, the measurement of serum BDE209 was rarely included in previous studies (Sjodin et al, 2008;Brasseur et al, 2014;Haraguchi et al, 2016).…”

Section: Oc Exposurementioning

confidence: 99%

Disruption of thyroid hormone (TH) levels and TH-regulated gene expression by polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and hydroxylated PCBs in e-waste recycling workers

Zheng

Chen

et al. 2017

Environment International

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Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are the primary toxicants released by electronic waste (e-waste) recycling, but their adverse effects on people working in e-waste recycling or living near e-waste sites have not been studied well. In the present study, the serum concentrations of PBDEs, PCBs, and hydroxylated PCBs, the circulating levels of thyroid hormones (THs), and the mRNA levels of seven TH-regulated genes in peripheral blood leukocytes of e-waste recycling workers were analyzed. The associations of the hormone levels and gene expression with the exposure to these contaminants were examined using multiple linear regression models. There were nearly no associations of the TH levels with PCBs and hydroxylated PCBs, whereas elevated hormone (T and T) levels were associated with certain lower-brominated BDEs. While not statistically significant, we did observe a negative association between highly brominated PBDE congeners and thyroid-stimulating hormone (TSH) levels in the e-waste workers. The TH-regulated gene expression was more significantly associated with the organohalogen compounds (OHCs) than the TH levels in these workers. The TH-regulated gene expression was significantly associated with certain PCB and hydroxylated PCB congeners. However, the expression of most target genes was suppressed by PBDEs (mostly highly brominated congeners). This is the first evidence of alterations in TH-regulated gene expression in humans exposed to OHCs. Our findings indicated that OHCs may interfere with TH signaling and/or exert TH-like effects, leading to alterations in related gene expression in humans. Further research is needed to investigate the mechanisms of action and associated biological consequences of the gene expression disruption by OHCs.

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Section: Oc Exposurementioning

confidence: 99%

Disruption of thyroid hormone (TH) levels and TH-regulated gene expression by polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and hydroxylated PCBs in e-waste recycling workers

Zheng

Chen

et al. 2017

Environment International

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“…[6][7][8][9][10][11][12]36 BPs and OH-BDEs are partially ionized at seawater pH, 37,38 but are nevertheless subject to bioaccumulation. 24,28,39 Diverse toxic effects of 2,4,6-triBP 40 and OH-BDEs [18][19][20] have been reported, and benecial antimicrobial activity has been attributed to 6-MeO-BDE47. 41 Many studies have demonstrated interconversion of BPs/BAs and OH-BDEs/MeO-BDEs through O-methylation/ demethylation reactions, 18,19,40 and it has been suggested that wildlife acquire OH-BDEs through O-demethylation of accumulated MeO-BDEs.…”

Section: Papermentioning

confidence: 99%

“…24,28,39 Diverse toxic effects of 2,4,6-triBP 40 and OH-BDEs [18][19][20] have been reported, and benecial antimicrobial activity has been attributed to 6-MeO-BDE47. 41 Many studies have demonstrated interconversion of BPs/BAs and OH-BDEs/MeO-BDEs through O-methylation/ demethylation reactions, 18,19,40 and it has been suggested that wildlife acquire OH-BDEs through O-demethylation of accumulated MeO-BDEs. 42 Thus, it is important to include both free phenolic and O-methylated forms in subsequent surveys, along with additional HNPs that have been reported in marine macroalgae; e.g.…”

Section: Papermentioning

confidence: 99%

“…4,17 Bromophenolic compounds enter the human diet through macroalgae consumption and from compounds bioaccumulated in seafood, and proles of MeO-BDE congeners in human serum reect dietary exposure. 18 Toxic properties associated with bromophenolic compounds include disruption of hormone synthesis or activity (OH-BDEs and MeO-BDEs) 19 and oxidative phosphorylation (OH-BDEs), 20 and binding to the aryl hydrocarbon (Ah) receptor (PBDDs). 21,22 Bromophenolic compounds have been identied in several macroalgae species from the Baltic Sea: Dictyosiphon foeniculaceus, Ceramium tenuicorne, Polysiphonia fucoides and Pilayella littoralis, as well as in cyanobacteria Nodularia spumigena and Aphanizomenon os-aquae, [8][9][10][11] but quantitative data have only been reported for C. tenuicorne, 11,[23][24][25] D. foeniculaceus 8 and N. spumigena.…”

Section: Introductionmentioning

confidence: 99%

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Bromoanisoles and methoxylated bromodiphenyl ethers in macroalgae from Nordic coastal regions

Bidleman

Andersson

Brügel

et al. 2019

Environ. Sci.: Processes Impacts

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“…Bisphenol A is also suggested as another suspected developmental neurotoxicant [ 25 ]. 4OH-PCB187 is one of main metabolites for PCBs and they concentration was found in blood at a higher concentration, rather than other congeners [ 26 ]. PCB and their metabolites are very similar to the structures of PBDEs and their hydroxyl metabolites [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres

Kikegawa

Qin

Ito

et al. 2020

IJMS

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Stress in early life has been linked with the development of late-life neurological disorders. Early developmental age is potentially sensitive to several environmental chemicals such as alcohol, drugs, food contaminants, or air pollutants. The recent advances using three-dimensional neural sphere cultures derived from pluripotent stem cells have provided insights into the etiology of neurological diseases and new therapeutic strategies for assessing chemical safety. In this study, we investigated the neurodevelopmental effects of exposure to thalidomide (TMD); 2,2′,4,4′-tetrabromodiphenyl ether; bisphenol A; and 4-hydroxy-2,2′,3,4′,5,5′,6-heptachlorobiphenyl using a human embryonic stem cell (hESC)-derived sphere model. We exposed each chemical to the spheres and conducted a combinational analysis of global gene expression profiling using microarray at the early stage and morphological examination of neural differentiation at the later stage to understand the molecular events underlying the development of hESC-derived spheres. Among the four chemicals, TMD exposure especially influenced the differentiation of spheres into neuronal cells. Transcriptomic analysis and functional annotation identified specific genes that are TMD-induced and associated with ERK and synaptic signaling pathways. Computational network analysis predicted that TMD induced the expression of DNA-binding protein inhibitor ID2, which plays an important role in neuronal development. These findings provide direct evidence that early transcriptomic changes during differentiation of hESCs upon exposure to TMD influence neuronal development in the later stages.

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Levels, profiles and dietary sources of hydroxylated PCBs and hydroxylated and methoxylated PBDEs in Japanese women serum samples

Cited by 36 publications

References 57 publications

Disruption of thyroid hormone (TH) levels and TH-regulated gene expression by polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and hydroxylated PCBs in e-waste recycling workers

Disruption of thyroid hormone (TH) levels and TH-regulated gene expression by polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and hydroxylated PCBs in e-waste recycling workers

Bromoanisoles and methoxylated bromodiphenyl ethers in macroalgae from Nordic coastal regions

Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres

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