“… 29 Genetic background and environmental factors, such as laboratory-specific handling and housing, have been reported to influence larval zebrafish behavior in zebrafish exposed to a range of chemicals, 65 , 66 including PFAS. 67 The data presented here reproduced PFOS- and PFHxS-dependent hyperactivity in the D1 period, despite study-specific differences in zebrafish strain and experimental design. This supports the concept that PFOS or PFHxS exposures disrupt neurodevelopment via a conserved mode of action(s).…”