mHealth offers a unique opportunity to improve access, quality, and adherence of care in last mile and low-resource settings around the world. However, the path to scale for mHealth interventions can be complex and challenging due to the barriers presented by fragmented infrastructure, policy gaps, and more. This chapter proposes a framework of nine key components that are essential for the successful scale-up of mHealth including mature infrastructure, a conducive policy environment, strong institutional partnerships, well-designed and contextappropriate technology, a skilled health workforce, financial sustainability, interoperability, and an evidence-based approach to mHealth. While not exhaustive, this framework offers implementers and policymakers a potential path to scale up mHealth interventions in order to strengthen health systems and improve health outcomes-particularly in remote communities around the world.