With the development of new technologies such as the Internet, cloud computing, artificial intelligence, and big data, new business models and new industrial forms have emerged. The demand for talents is also rapidly increasing across industries. This also puts forward new requirements for the cultivation of business talents and the reform of business teaching mode. “Inter-professional comprehensive training” is a highly applied course. By simulating real job content, business process, business documents, etc., students’ job skills, professional quality, business decision-making ability and innovation ability are cultivated. This paper analyzes the development of inter-professional comprehensive training in Z school, analyzes its existing problems, and proposes, among other things, targeted teaching reform suggestions, so as to provide reference for schools that carry out relevant courses.