Leveraging Pyrazolium Ylide Reactivity to Access Indolizine and 1,2‐Dihydropyrimidine Derivatives
Ricky Tran,
Duncan K. Brownsey,
Leonie O'Sullivan
et al.
Abstract:N‐Heterocyclic ylides are important synthetic precursors to rapidly build molecular complexity. Pyrazolium ylides have largely been unexplored, and we demonstrate their diverse utility in this report. We show that these readily accessible building blocks can be used to construct different heterocyclic skeletons by varying the coupling partner. Indolizines can be formed via an N‐deletion type mechanism when reacting pyrazolium salts with electron deficient alkynes. 1,2‐Dihydropyrimidines can be formed via a rea… Show more
Ring architecture not only influences molecular properties, spatial arrangement, and scaffold rigidity but also determines molecular function and regulation. Compared with the traditional construction of ring frameworks that often requires...
Ring architecture not only influences molecular properties, spatial arrangement, and scaffold rigidity but also determines molecular function and regulation. Compared with the traditional construction of ring frameworks that often requires...
Breaking the aromaticity by inserting additional atoms within the skeleton of heteroaromatic rings has gained a flourishing significance over the past years. As part of the emerging concept of “Skeletal Editing”, this short review retraces the recent progresses in dearomative enlargement reactions of both 5- and 6-membered heterocycles.
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