Leveraging Technology to Manage Chagas Disease by Tracking Domestic and Sylvatic Animal Hosts as Sentinels: A Systematic Review

Kruse, Clemens Scott; Guerra, David A.; Gelillo-Smith, Raena; Vargas, Amber; Krishnan, Laavanya; Granados, Paula Stigler

doi:10.4269/ajtmh.19-0050

Cited by 8 publications

(7 citation statements)

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“…The routine uses of domestic animals, mainly dogs, as sentinels to monitor the epidemiological risk of Chagas disease has been previously proposed, and the diverse spectrum of dog surveys performed in American countries has confirmed the risk for T. cruzi infection [11][12][13][14]26,[28][29][30] . The seropositivity rate was 4.44% in the presence of anti-T. cruzi as demonstrated in dog sera from Sonora, Mexico, and the data highlighted the direct correlation between seropositivity rate in dogs and the presence of antibodies against T. cruzi in humans in different regions of Mexico 26 .…”

Section: The Incidence Of Acute Chagas Disease Due To Oral Transmissionmentioning

confidence: 99%

Profile of natural Trypanosoma cruzi infection among dogs from rural areas of southern Espírito Santo, Brazil

Pontes

Kuster

Freitas

et al. 2022

Rev. Soc. Bras. Med. Trop.

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Background:The emergence of Trypanosoma cruzi infection via oral transmission has a habitual character in its primitive endemic cycle. Recent findings revealed the first death by oral transmission of T. cruzi in the state of Espírito Santo, Brazil, in 2012, which was recorded in the rural area of Guarapari. This study evaluated the characteristics related to the occurrence of natural T. cruzi infection among dogs from the rural areas of Alegre and Iconha, municipalities of Espírito Santo.Methods: Logistic regression analysis of factors contributing to serological detection of T. cruzi in dogs was performed in environments where Espírito Santo's Department of Health Surveillance had previously notified triatomines positive for Trypanosoma spp. from 2014 to 2017.Results: A total of 36 dogs were analyzed, of which 10 (27.77%) tested positive, one was borderline (2.79%), and 25 tested negative (69.44%) for T. cruzi infection. São Caetano, a district from the Iconha municipality, presented a 25 times greater chance for the detection of positive tests (OR:25; 95% CI; 2.37->100). Dogs with updated mandatory vaccination presented with a lower risk of positive serodiagnosis (OR:0.12; 95% CI: 0.02-0.63). Conclusions:Our results highlight for the first time the occurrence of natural T. cruzi canine infection, detected in the municipality of Iconha, mainly among dogs with un-updated mandatory vaccines in the district of São Caetano.

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Section: The Incidence Of Acute Chagas Disease Due To Oral Transmissionmentioning

confidence: 99%

Profile of natural Trypanosoma cruzi infection among dogs from rural areas of southern Espírito Santo, Brazil

Pontes

Kuster

Freitas

et al. 2022

Rev. Soc. Bras. Med. Trop.

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“…The surveillance of disease in domestic canines has been used to monitor the prevalence of arthropod-borne illnesses such as Lyme disease, Chagas disease, leishmaniasis, and others . Chickens and goats have been monitored for Chagas disease, and goats have also been used as sentinel hosts for tick-borne encephalitis. Pigs have been used to track influenza A and Japanese encephalitis .…”

Section: Early Warning Of Zoonotic Diseasesmentioning

confidence: 99%

Early Warning Diagnostics for Emerging Infectious Diseases in Developing into Late-Stage Pandemics

et al. 2021

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Conspectus The spread of infectious diseases due to travel and trade can be seen throughout history, whether from early settlers or traveling businessmen. Increased globalization has allowed infectious diseases to quickly spread to different parts of the world and cause widespread infection. Posthoc analysis of more recent outbreaksSARS, MERS, swine flu, and COVID-19has demonstrated that the causative viruses were circulating through populations for days or weeks before they were first detected, allowing disease to spread before quarantines, contact tracing, and travel restrictions could be implemented. Earlier detection of future novel pathogens could decrease the time before countermeasures are enacted. In this Account, we examined a variety of novel technologies from the past 10 years that may allow for earlier detection of infectious diseases. We have arranged these technologies chronologically from prehuman predictive technologies to population-level screening tools. The earliest detection methods utilize artificial intelligence to analyze factors such as climate variation and zoonotic spillover as well as specific species and geographies to identify where the infection risk is high. Artificial intelligence can also be used to monitor health records, social media, and various publicly available data to identify disease outbreaks faster than traditional epidemiology. Secondary to predictive measures is monitoring infection in specific sentinel animal species, where domestic animals or wildlife are indicators of potential disease hotspots. These hotspots inform public health officials about geographic areas where infection risk in humans is high. Further along the timeline, once the disease has begun to infect humans, wastewater epidemiology can be used for unbiased sampling of large populations. This method has already been shown to precede spikes in COVID-19 diagnoses by 1 to 2 weeks. As total infections increase in humans, bioaerosol sampling in high-traffic areas can be used for disease monitoring, such as within an airport. Finally, as disease spreads more quickly between humans, rapid diagnostic technologies such as lateral flow assays and nucleic acid amplification become very important. Minimally invasive point-of-care methods can allow for quick adoption and use within a population. These individual diagnostic methods then transfer to higher-throughput methods for more intensive population screening as an infection spreads. There are many promising early warning technologies being developed. However, no single technology listed herein will prevent every future outbreak. A combination of technologies from across our infection timeline would offer the most benefit in preventing future widespread disease outbreaks and pandemics.

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“…Between semesters, I enter into partnership with those graduate students whose work is of high quality and also research viable topics for the following term. With this protocol, I have helped 77/151 (51%) graduate students publish 27 systematic reviews [1-27] (two in press) in nine high-quality journals worldwide over the last 5 years: Journal of Medical Internet Research [2,4,8-11,14,15,17,18,26], Journal of Medical Systems [19,20,23,24], Journal of Telemedicine and Telecare [3,22], Technology and Healthcare, [5,6], BMJ Open [16,21], JRSM Open [12], Applied Clinical Informatics [25], Journal of Rehabilitation Medicine [27], and American Journal of Tropical Medicine and Hygiene [1].…”

Section: Introductionmentioning

confidence: 99%

Writing a Systematic Review for Publication in a Health-Related Degree Program

Kruse¹

2019

JMIR Res Protoc

Self Cite

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BackgroundThe protocol in this manuscript was designed to help graduate students publish. It is the result of a challenge from our provost in 2013. I developed this protocol over the last 6 years and have exercised the protocol for the last 5 years. The current version of the protocol has remained mostly static for the last 2 years—only small changes have been made to the process.ObjectiveThe objective of this protocol is to enable students to learn a valuable skill of conducting a systematic review and to write the review in a way that can be published. I have designed the protocol to fit into the schedule of a traditional semester, but also used it in compressed semesters.MethodsAn image map was created in HTML 5.0 and imported into a learning management system. It augments traditional instruction by providing references to published articles, examples, and previously recorded instructional videos. Students use the image map outside the classroom after traditional instruction. The image map helps students create manuscripts that follow established practice and are reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and whose authorship follows guidelines by the International Committee of Medical Journal Editors.ResultsSince its inception, this protocol has helped 77 students publish 27 systematic reviews in nine journals worldwide. Some manuscripts take multiple years to progress through multiple review processes at multiple journals submitted in sequence. Two other professors in the School of Health Administration have used this protocol in their classes.ConclusionsSo far, this method has helped 51% of graduate students who used it in my graduate courses publish articles (with more manuscripts under consideration whose numbers have remained uncounted in this sum). I wish success to others who might use this protocol.

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Leveraging Technology to Manage Chagas Disease by Tracking Domestic and Sylvatic Animal Hosts as Sentinels: A Systematic Review

Cited by 8 publications

References 50 publications

Profile of natural Trypanosoma cruzi infection among dogs from rural areas of southern Espírito Santo, Brazil

Profile of natural Trypanosoma cruzi infection among dogs from rural areas of southern Espírito Santo, Brazil

Early Warning Diagnostics for Emerging Infectious Diseases in Developing into Late-Stage Pandemics

Writing a Systematic Review for Publication in a Health-Related Degree Program

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