Leveraging the Modularity of Biomaterial Carriers to Tune Immune Responses

Tsai, Shannon; Black, Sheneil K; Jewell, Christopher M.

doi:10.1002/adfm.202004119

Cited by 19 publications

(17 citation statements)

References 149 publications

(242 reference statements)

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“…An appropriate biodegradable porous scaffold can mimic the ECM for cell attachment, proliferation and differentiation of cells in bone tissue engineering [ 245 ]. Accumulated studies have revealed that the implanted biomaterials can play an important role in the regulation of biological activity of host cells [ 246–248 ]. Scientists thereby began to seek an approach that enables biomaterials to stimulate host cells to function in angiogenesis.…”

Section: Applications Of Biomaterials In Tissue Regenerationmentioning

confidence: 99%

Recent advances in regenerative biomaterials

Cao

Ding

2022

Regenerative Biomaterials

115

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Nowadays, biomaterials have evolved from the inert supports or functional substitutes, to the bioactive materials able to trigger or promote the regenerative potential of tissues. The interdisciplinary progress has broadened the definition of “biomaterials”, and a typical new insight is the concept of tissue induction biomaterials. The term “regenerative biomaterials” and thus the contents of the present paper are relevant to yet beyond tissue induction biomaterials. This review summarizes the recent progress of medical materials including metals, ceramics, hydrogels, other polymers, and bio-derived materials. As the application aspects are concerned, this paper introduces regenerative biomaterials for bone and cartilage regeneration, cardiovascular repair, three dimensional bioprinting, wound healing, and medical cosmetology. Cell-biomaterial interactions are highlighted. Since the global pandemic of COVID-19, the review particularly mentions biomaterials for public health emergency. In the last section, perspectives are suggested: (1) Creation of new materials is the source of innovation; (2) Modification of existing materials is an effective strategy for performance improvement; (3) Biomaterial degradation and tissue regeneration are required to be harmonious with each other; (4) Host responses can significantly influence the clinical outcomes; (5) The long-term outcomes should be paid more attention to; (6) The non-invasive approaches for monitoring in vivo dynamic evolution are required to be developed; (7) Public health emergencies call for more research & development of biomaterials; (8) Clinical translation needs to be pushed forward in a full-chain way. In the future, more new insights are expected to be shed into the brilliant field — regenerative biomaterials.

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Section: Applications Of Biomaterials In Tissue Regenerationmentioning

confidence: 99%

Recent advances in regenerative biomaterials

Cao

Ding

2022

Regenerative Biomaterials

115

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“…17, 38-40 A growing body of work demonstrated that immune cells require precise spatial and temporal cues to drive specified responses, supporting the idea that spatiotemporal control of vaccines can have a profound effect on the magnitude and quality of the immune response. 41-50…”

Section: Introductionmentioning

confidence: 99%

“…17,[38][39][40] A growing body of work demonstrated that immune cells require precise spatial and temporal cues to drive specified responses, supporting the idea that spatiotemporal control of vaccines can have a profound effect on the magnitude and quality of the immune response. [41][42][43][44][45][46][47][48][49][50] The precise spatiotemporal control of vaccines can also be achieved by localized slow delivery of vaccine components. Recent proof-of-concept studies have shown that sustained release of an HIV vaccine through implantable osmotic pumps led to greatly improved quality of vaccine responses, such as durable germinal center (GC) responses, high antibody titers, and development of better virus neutralization compared to standard soluble administration of the same vaccine.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-Conjugated TLR9 Agonists Improve the Potency, Durability, and Breadth of COVID-19 Vaccines

Picece

Baillet

et al. 2023

Preprint

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Development of effective vaccines for infectious diseases has been one of the most successful global health interventions in history. Though, while ideal subunit vaccines strongly rely on antigen and adjuvant(s) selection, the mode and timescale of exposure to the immune system has often been overlooked. Unfortunately, poor control over the delivery of many adjuvants, which play a key role in enhancing the quality and potency of immune responses, can limit their efficacy and cause off-target toxicities. There is critical need for new adjuvant delivery technologies to enhance their efficacy and boost vaccine performance. Nanoparticles (NPs) have been shown to be ideal carriers for improving antigen delivery due to their shape and size, which mimic viral structures, but have been generally less explored for adjuvant delivery. Here, we describe the design of self-assembled poly(ethylene glycol)-b-poly(lactic acid) nanoparticles decorated with CpG, a potent TLR9 agonist, to increase adjuvanticity in COVID-19 vaccines. By controlling the surface density of CpG, we show that intermediate valency is a key factor for TLR9 activation of immune cells. When delivered with the SARS-CoV-2 spike protein, CpG NP adjuvants greatly improve the magnitude and duration of antibody responses when compared to free CpG, and result in overall greater breadth of immunity against variants of concern. Moreover, encapsulation of CpG NPs into injectable polymeric-nanoparticle (PNP) hydrogels enhance the spatiotemporal control over co-delivery of CpG NP adjuvant and spike protein antigen such that a single immunization of hydrogel-based vaccines generates comparable humoral responses as a typical prime-boost regimen of soluble vaccines. These delivery technologies can potentially reduce the costs and burden of clinical vaccination, both of which are key elements in fighting a pandemic.

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“…Across these categories, a generally attractive feature is the ability for improved levels of control. For example, many biomaterials provide tunable control over loading and release of multiple immune cues, targeting specific cells or tissues, cargo protection, and control over release kinetics (13). The ability to chemically modify and functionalize the surface of nano-or microparticles also offers a modular ability that is particularly attractive in displaying immune cues to direct immune processes (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Mapping the Mechanical and Immunological Profiles of Polymeric Microneedles to Enable Vaccine and Immunotherapy Applications

et al. 2022

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Biomaterials hold great promise for vaccines and immunotherapy. One emerging biomaterials technology is microneedle (MNs) delivery. MNs are arrays of micrometer-sized needles that are painless and efficiently deliver cargo to the specialized immunological niche of the skin. MNs typically do not require cold storage and eliminate medical sharps. Nearly all materials exhibit intrinsic properties that can bias immune responses toward either pro-immune or inhibitory effects. Thus, because MNs are fabricated from degradable polymers to enable cargo loading and release, understanding the immunological profiles of these matrices is essential to enable new MN vaccines and immunotherapies. Additionally, understanding the mechanical properties is important because MNs must penetrate the skin and conform to a variety of skin or tissue geometries. Here we fabricated MNs from important polymer classes – including extracellular matrix biopolymers, naturally-derived polymers, and synthetic polymers – with both high- and low-molecular-weights (MW). We then characterized the mechanical properties and intrinsic immunological properties of these designs. The library of polymer MNs exhibited diverse mechanical properties, while causing only modest changes in innate signaling and antigen-specific T cell proliferation. These data help inform the selection of MN substrates based on the mechanical and immunological requirements needed for a specific vaccine or immunotherapy application.

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Leveraging the Modularity of Biomaterial Carriers to Tune Immune Responses

Cited by 19 publications

References 149 publications

Recent advances in regenerative biomaterials

Recent advances in regenerative biomaterials

Nanoparticle-Conjugated TLR9 Agonists Improve the Potency, Durability, and Breadth of COVID-19 Vaccines

Mapping the Mechanical and Immunological Profiles of Polymeric Microneedles to Enable Vaccine and Immunotherapy Applications

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