Levetiracetam pharmacokinetics in critically ill patients undergoing renal replacement therapy

Chappell, Kathryn; Kimmons, Lauren A.; Haller, J Tyler; Canada, Robert B.; He, Hui; Hudson, Joanna Q.

doi:10.1016/j.jcrc.2020.10.032

Cited by 9 publications

(10 citation statements)

References 22 publications

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“…Benzodiazepines are typically the first line of therapy for any seizure in the ICU. Levetiracetam has become a popular choice for second-line therapy because of its favorable side effect profile compared with fosphenytoin, although it may need dose adjustment in patients with impaired renal clearance 100 . Valproate can be used as a second-line treatment, although it should be avoided in patients with hepatic failure or thrombocytopenia.…”

Section: Seizure Syndromesmentioning

confidence: 99%

Neurologic Complications of Critical Medical Illness

Morris¹,

Sarwal²

2023

CONTINUUM: Lifelong Learning in Neurology

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Objective This article reviews the neurologic complications encountered in patients admitted to non-neurologic intensive care units, outlines various scenarios in which a neurologic consultation can add to the diagnosis or management of a critically ill patient, and provides advice on the best diagnostic approach in the evaluation of these patients. Latest Developments Increasing recognition of neurologic complications and their adverse impact on long-term outcomes has led to increased neurology involvement in non-neurologic intensive care units. The COVID-19 pandemic has highlighted the importance of having a structured clinical approach to neurologic complications of critical illness as well as the critical care management of patients with chronic neurologic disabilities. Essential Points Critical illness is often accompanied by neurologic complications. Neurologists need to be aware of the unique needs of critically ill patients, especially the nuances of the neurologic examination, challenges in diagnostic testing, and neuropharmacologic aspects of commonly used medications.

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Section: Seizure Syndromesmentioning

confidence: 99%

Neurologic Complications of Critical Medical Illness

Morris¹,

Sarwal²

2023

CONTINUUM: Lifelong Learning in Neurology

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“…As with individual Unit CRRT protocols, there are significant practice variations in the provision of SLEDD across institutions, with respect to dialysis prescription, technology and blood flow rates. The following references demonstrate how different SLEDD set ups and protocols can be [7,[12][13][14][15][16]] and these differences will effect clearances of antibiotics and in fact other drugs such as levetiracetam [17]. Conceptual dosing strategies across a 24 h period with a 4 h sledd procedure.…”

Section: Sledd and Antibiotic Pdmentioning

confidence: 99%

Antibiotic dosing in sustained low-efficiency daily dialysis (SLEDD): Basic concepts and dosing strategies

Lee

Waele

Lipman

2022

Journal of Critical Care

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“…Common pharmacokinetic characteristics of medications are summarized in Table 2 . 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125…”

Section: Review Of Literaturementioning

confidence: 99%

“…q. 6–12 h Levetiracetam 82 , 83 , 84 , 85 170 <10 0.5 6 Lipophilic Urine Seizures: 750–1000 mg q 12 h Phenytoin 86 , 87 252 90 0.5 12 Lipophilic; evaluate free phenytoin concentrations Urine Seizures: 15 mg/kg (max. 2 g) i.v.…”

Section: Review Of Literaturementioning

confidence: 99%

“…Morphine is not significantly removed by CVVH or CVVHD, 73 and the extent of M3G and M6G removal is unknown Fentanyl 74 No data on CRRT; Use lowest effective dose with gradual titration and close monitoring of response and adverse effects (expert opinion). Dose for GFR 10−50 (expert opinion) Methadone 75 No data on CRRT; Dose for GFR 10−50 (expert opinion) Anticonvulsants Valproic acid 76 , 77 , 78 Removed by CVVH 36 , 77 No data Removed by CVVHDF 78 Carbamazepine 79 , 80 , 81 No data Removed by CVVHD 80 a Removed by CVVHD 81 Levetiracetam 82 , 83 , 84 , 85 Cleared by CVVH 83 , 85 No data Removed by CVVHDF 83 , 84 Phenytoin 86 , 87 Approximately 30% cleared by CVVH 87 No data No data Lacosamide 88 , 89 , 90 Significant removal by CVVH 89 , 90 No data No data Topiramate 91 , 92 No data No data Removed by CVVHDF ...…”

Section: Review Of Literaturementioning

confidence: 99%

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A Clinician’s Guide to Dosing Analgesics, Anticonvulsants, and Psychotropic Medications in Continuous Renal Replacement Therapy

Bouajram

Awdishu

2021

Kidney International Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Levetiracetam pharmacokinetics in critically ill patients undergoing renal replacement therapy

Cited by 9 publications

References 22 publications

Neurologic Complications of Critical Medical Illness

Neurologic Complications of Critical Medical Illness

Antibiotic dosing in sustained low-efficiency daily dialysis (SLEDD): Basic concepts and dosing strategies

A Clinician’s Guide to Dosing Analgesics, Anticonvulsants, and Psychotropic Medications in Continuous Renal Replacement Therapy

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