Levitation of red blood cells in microchannel for microfluidic MEMS healthcare device application

Kumar, Mahesh; Palekar, Nikhil; Kumar, Ajai; Sharma, Niti Nipun; Akhtar, Jamil; Singh, Kulwant

doi:10.1016/j.matpr.2021.02.735

Cited by 2 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microfluidic pressure sensing with the cantilever-based sensing mechanism is more appropriate for the measurement of fluid properties in the field of biomedical applications due to its low-cost fabrication, easy steps to design, and easy microscopic measurement of deflection [36]. This technique of measuring the deflection of a cantilever through the optical microscope avoids the use of any piezoelectric or piezoresistive sensors with the microchannel and hence avoids the additional integration artefacts [37][38][39][40]. In the previously discussed literature, the researchers investigated pressure and fluid properties across/in a microchannel.…”

Section: Introductionmentioning

confidence: 99%

An efficient microfluidic pressure sensing structure optimization using microcantilever integration

et al. 2023

Self Cite

View full text Add to dashboard Cite

Microfluidic pressure sensors are extensively present in a wide range of applications such as wearable devices, drug detection, and many healthcare applications. Integrated microfluidic pressure sensors are highly desirable in many fields where it offers high sensitivity, non-toxicity, and high biocompatibility. In the present work, an integrated microfluidic pressure sensing mechanism is analyzed in a microfluidic device. The device is composed of poly dimethyl siloxane (PDMS) based material with a microcantilever of the same material integrated on one side of the microchannel. The pressure of fluid in the microchannel is measured by deflection generated on the PDMS microcantilever while the fluid is made to be drive-in. The pressure-based deflection measurement process is analyzed for different types of fluids and the geometry of microcantilevers. The designs for the microcantilevers are considered rectangular-shaped, T-shaped, and Pi-shaped cantilever. The modelling and analysis are done in the commercially available software tool COMSOL Multiphysics®. The results have shown that maximum deflection is achieved with a Pi-shaped microcantilever in fluid plasma (37.05 µm) and in water (30.98 µm) at 8000 µm/s fluid inlet velocity. This maximum deflection was found to be in cooperation with the pressure value at the channel inlet 125.1 Pa for Pi-microcantilever. The optimization is achieved for improved fluid pressure sensing with an integrated microcantilever, which reduces the device setup for fluid pressure analysis. The purpose of research and study is to control fluid pressure inside microfluidic channels, which can pave the way for efficient small setup cytometry and cell separation microfluidic devices.

show abstract

Section: Introductionmentioning

confidence: 99%

An efficient microfluidic pressure sensing structure optimization using microcantilever integration

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Dabighi et al proposed a cell separation device for circulating tumour cells (CTCs) isolation but, the design was not for multiple cell processing [21]. DEP technology has been used for many cell/particle manipulations purposes like levitation [22,23], specific cell positioning [24,25], focusing [26,27], aligning [28], single-cell caging for cell parameter measurements [28], trapping [29], and separation [28,[30][31][32][33] however continuous-time cell separation is the most attractive for health care diagnostic applications.…”

Section: Introductionmentioning

confidence: 99%

A novel microfluidic device with tapered sidewall electrodes for efficient ternary blood cells (WBCs, RBCs and PLTs) separation

Kumar¹,

Kumar²,

George³

et al. 2021

Meas. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Separation and counting of blood cells from whole blood is very significant in measurement and data extraction in health care diagnostics and monitoring health parameters. Many techniques are available for blood cell separation out of which dielectrophoresis (DEP) on lab on chip platform is an emerging technique due to its phenomenal advantages that the force in this technique acts directly on cells based on dielectric properties. In DEP more challenges lie in optimization of the electric field at lower operating voltages as higher voltages damage the biological cells via joule heating and the separation process cannot be accomplished. Due to this optimization of the electric field distribution in the microchannel of the cell separation device is very much important and can be achieved via numerical model or design optimization of electrodes shapes and material. In this work, a microfluidic cell separation device is optimized using the finite element method for the ternary separation of blood cells. The design is realized with two inlets, three outlets, and one main channel having tapered sidewall electrodes for cell separation purpose. Inlet velocities are optimized to achieve improved cell focusing before subjecting cells to separation effects by varying the velocity ratio of main inlet velocity to buffer inlet velocity. Results have shown successful separation of platelets, red blood cells, and white blood cells with 96.7%–100% yield and purity with velocity ratio from 1:4 to 1:5 at electrode excitation voltage of 1.5 V.

show abstract

Levitation of red blood cells in microchannel for microfluidic MEMS healthcare device application

Cited by 2 publications

References 9 publications

An efficient microfluidic pressure sensing structure optimization using microcantilever integration

An efficient microfluidic pressure sensing structure optimization using microcantilever integration

A novel microfluidic device with tapered sidewall electrodes for efficient ternary blood cells (WBCs, RBCs and PLTs) separation

Contact Info

Product

Resources

About