Levobupivacaine intravesical injection for superficial bladder tumor resection—possible, effective, and durable. Preliminary clinical data

Stravodimos, Konstantinos; Mitropoulos, Dionysios; Salvari, A.; Lampadariou, A.; Kapetanakis, Theodoros N.; Zervas, Anastasios

doi:10.1007/s11255-007-9295-6

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…Regional anaesthesia is divided in epidural, spinal, and saddle blockade anaesthesia. Recently, local anesthesia with infiltration of the bladder wall or periprostatic nerve blockage was reported [1–3]. Additionally, sedoanalgesia which is the combination of local anaesthesia with sedation or even the use of virtual reality for pain management has been examined [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Spinal versus General Anaesthesia in Postoperative Pain Management during Transurethral Procedures

et al. 2011

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We compared the analgesic efficacy of spinal and general anaesthesia following transurethral procedures. 97 and 47 patients underwent transurethral bladder tumour resection (TUR-B) and transurethral prostatectomy (TUR-P), respectively. Postoperative pain was recorded using an 11-point visual analogue scale (VAS). VAS score was greatest at discharge from recovery room for general anaesthesia (P = 0.027). The pattern changed significantly at 8 h and 12 h for general anaesthesia's efficacy (P = 0.017 and P = 0.007, resp.). A higher VAS score was observed in pT2 patients. Patients with resected tumour volume >10 cm3 exhibited a VAS score >3 at 8 h and 24 h (P = 0.050, P = 0.036, resp.). Multifocality of bladder tumours induced more pain overall. It seems that spinal anaesthesia is more effective during the first 2 postoperative hours, while general prevails at later stages and at larger traumatic surfaces. Finally, we incidentally found that tumour stage plays a significant role in postoperative pain, a point that requires further verification.

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Section: Introductionmentioning

confidence: 99%

Spinal versus General Anaesthesia in Postoperative Pain Management during Transurethral Procedures

et al. 2011

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“…However, these studies are case series and have not yet become the standard approach. In addition, Stravodimos et al have published that local levobupivacaine intravesical infiltration in the resection of superficial bladder tumours is an appropriate method for pain control and can be an alternative to general anaesthesia 26 . This was a pilot study reporting that levobupivacaine was first administered as intraurethral infiltration.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Stravodimos et al have published that local levobupivacaine intravesical infiltration in the resection of superficial bladder tumours is an appropriate method for pain control and can be an alternative to general anaesthesia. 26 This was a pilot study reporting that levobupivacaine was first administered as intraurethral infiltration. It is one of the most reliable local anaesthetics in terms of side-effects because levobupivacaine passes into the systemic circulation on a limited amount.…”

Section: Ta B L E 2 Patient Satisfaction Values Of Groupsmentioning

confidence: 99%

Efficiency of intracavitary levobupivacaine infusion for pain management during cystoscopic procedures: A randomised study

et al. 2021

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Aim: This study evaluated the effect of intracavitary levobupivacaine infusion diluted with locally applied isotonic solution for pain control in cystoscopy.Methods: Included in this study are 100 patients who had previously undergone transurethral tumour resection for bladder tumour and were followed up by cystoscopy. The patients were randomised into five groups (n = 20). In the first, second, third, and fourth groups, 4, 6, 8, and 10 mL of levobupivacaine HCl (5.0 mg/mL) were mixed with 26, 24, 22, and 20 mL of isotonic solution, respectively. Hence, the total mixture was 30 mL for each group. The fifth group was the control group. In this group, the standard method commonly used in most clinics was utilised. That is, a gel containing Cathejell-2% lidocaine (25 mg lidocaine) was applied for local analgesia. Cystoscopic interventions were performed with a 17.5 Fr rigid cystoscope and 0°, 30°, and 70° lens. During cystoscopy and 30 min later, the pain status of patients was assessed using the Visual Analogue Scale (VAS) and patient satisfaction was questioned. Results:The mean VAS score during and after the cystoscopy procedure was significantly lower in the levobupivacaine groups compared with the lidocaine group. In addition, patient satisfaction in the levobupivacaine groups was significantly higher than in the lidocaine group. No drug-related side-effects were observed in all groups. Conclusion:Thus, levobupivacaine is a more effective drug than lidocaine alone to control pain during cystoscopy. The use of levobupivacaine is recommended to prevent possible complications of general anaesthesia by eliminating the need for the aforementioned as well as its cost-saving advantage. What's known• While the cystoscopy procedure is mostly performed with flexible cystoscopes in developed countries for the patient's best comfort, rigid cystoscopy is still mostly preferred in developing or underdeveloped countries due to its cost-effectiveness. Pain management is essential for optimum procedure in local setting.

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Removal of Ureteric Stents

Kulkarni

2017

Ureteric Stenting

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Levobupivacaine intravesical injection for superficial bladder tumor resection—possible, effective, and durable. Preliminary clinical data

Cited by 5 publications

References 14 publications

Spinal versus General Anaesthesia in Postoperative Pain Management during Transurethral Procedures

Spinal versus General Anaesthesia in Postoperative Pain Management during Transurethral Procedures

Efficiency of intracavitary levobupivacaine infusion for pain management during cystoscopic procedures: A randomised study

Removal of Ureteric Stents

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