Levodopa analgesia in experimental neuropathic pain

Cobacho, Nuria; Calle, José Luis de la; González-Escalada, J. R.; Paı́no, Carlos Luis

doi:10.1016/j.brainresbull.2010.08.012

Cited by 37 publications

(19 citation statements)

References 46 publications

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“…L-DOPA, after conversion to dopamine, reduces nociceptive behavior induced by intrathecal administration of substance P in rats, via a D2R-dependent mechanism [91]. In rats with CCI, intrathecally injected L-DOPA reduces mechanical and thermal hyperalgesia, again through D2R actions [14]. Interestingly, the D2R-dependent antinociceptive effect seems to be enhanced after CCI [14] or spinal nerve ligation [2,76], possibly due to injury-induced D2R upregulation in pre- and/or post-synaptic sites in the dorsal horn [2].…”

Section: Potential Catecholaminergic Phenotype and Pain Modulationmentioning

confidence: 99%

Dorsal root ganglion neurons and tyrosine hydroxylase—an intriguing association with implications for sensation and pain

Brumovsky

2016

Pain

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Tyrosine hydroxylase (TH) is a rate-limiting enzyme broadly expressed in noradrenergic and dopaminergic neurons in the central nervous system [57,70]. TH is also expressed by peripheral sympathetic neurons [98] as well as by enteric neurons within the gut [81,84]. Over 30 years ago, TH was unexpectedly discovered in developing and adult rodent cranial and dorsal root ganglion (DRG) neurons. Today, TH-expressing DRG neurons are being re-discovered as a relevant subpopulation. This review addresses the emerging importance of TH-expressing DRG neurons in sensation and pain mechanisms, focusing specifically on: 1) their nature as C-low threshold mechanoreceptors (C-LTMRs); 2) their involvement in nociception/pain; and 3) their catecholaminergic phenotype.

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Section: Potential Catecholaminergic Phenotype and Pain Modulationmentioning

confidence: 99%

Dorsal root ganglion neurons and tyrosine hydroxylase—an intriguing association with implications for sensation and pain

Brumovsky

2016

Pain

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“…7a). Moreover, combined treatment (but not either alone 14–16 ) blocked the development of tactile allodynia in SNI mice and rats (Fig. 2g and Supplementary Fig.…”

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confidence: 94%

The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

et al. 2015

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We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.

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“…Three previous studies have shown the analgesia of levodopa in animal models 7,8,10. However, only one study investigated neuropathic pain.…”

Section: Discussionmentioning

confidence: 99%

“…Levodopa has been shown to have anti-nociceptive properties in animal studies,7,8 acting at the level of the spinal cord or the brain via the dopaminergic receptors. Animal studies on the analgesic activity of levodopa, in the setting of chronic pain, have been limited and inconclusive 9,10. Therefore, the aim of this study was to investigate, in a rat model, the anti-allodynic effects of levodopa to determine if levodopa should be further investigated as a novel treatment modality in humans.…”

Section: Introductionmentioning

confidence: 99%

Anti-Allodynic Effects of Levodopa in Neuropathic Rats

et al. 2013

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PurposeLevodopa is the most effective anti-Parkinsonian agent. It has also been known to exhibit analgesic properties in laboratory and clinical settings. However, studies evaluating its effects on neuropathic pain are limited. The aim of the present study was to examine the anti-allodynic effects of levodopa in neuropathic rats.Materials and MethodsSprague-Dawley male rats underwent the surgical procedure for L5 and L6 spinal nerves ligation. Sixty neuropathic rats were randomly divided into 6 groups for the oral administration of distilled water and levodopa at 10, 30, 50, 70, and 100 mg/kg, respectively. We co-administered carbidopa with levodopa to prevent peripheral synthesis of dopamine from levodopa, and observed tactile, cold, and heat allodynia pre-administration, and at 15, 30, 60, 90, 120, 150, 180, and 240 min after drug administration. We also measured locomotor function of neuropathic rats using rotarod test to examine whether levodopa caused side effects or not.ResultsDistilled water group didn't show any difference in all allodynia. For the levodopa groups (10-100 mg/kg), tactile and heat withdrawal thresholds were increased, and cold withdrawal frequency was decreased dose-dependently (p<0.01). In addition, levodopa induced biphasic analgesia. Different dosage of levodopa did not impact on the rotarod time (p>0.05).ConclusionLevodopa reversed tactile, cold and heat allodynia in neuropathic rat without any side effects.

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Levodopa analgesia in experimental neuropathic pain

Cited by 37 publications

References 46 publications

Dorsal root ganglion neurons and tyrosine hydroxylase—an intriguing association with implications for sensation and pain

Dorsal root ganglion neurons and tyrosine hydroxylase—an intriguing association with implications for sensation and pain

The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

Anti-Allodynic Effects of Levodopa in Neuropathic Rats

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