Levodopa improves handwriting and instrumental tasks in previously treated patients with Parkinson’s disease

Müller, Thomas; Harati, Ali

doi:10.1007/s00702-020-02246-3

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…Micrographia reduces patients’ overall quality of life in subtle yet noticeably debilitating ways [ 10 , 11 ]. Variable improvements in handwriting have been reported following treatment with standard PD medications [ 13 ]. Therefore, adjuncts such as physiotherapy are commonly used, with the goal of preserving and improving motor symptoms such as micrographia.…”

Section: Introductionmentioning

confidence: 99%

Intensive training programme improves handwriting in a community cohort of people with Parkinson’s disease

Collins,

Roberts,

Cleary

et al. 2023

Ir J Med Sci

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Background People with Parkinson’s disease (PwP) often report problems with their handwriting before they receive a formal diagnosis. Many PwP suffer from deteriorating handwriting throughout their illness, which has detrimental effects on many aspects of their quality of life. Aims To assess a 6-week online training programme aimed at improving handwriting of PwP. Methods Handwriting samples from a community-based cohort of PwP (n = 48) were analysed using systematic detection of writing problems (SOS-PD) by two independent raters, before and after a 6-week remotely monitored physiotherapy-led training programme. Inter-rater variability on multiple measures of handwriting quality was analysed. The handwriting data was analysed using pre-/post-design in the same individuals. Multiple aspects of the handwriting samples were assessed, including writing fluency, transitions between letters, regularity in letter size, word spacing, and straightness of lines. Results Analysis of inter-rater reliability showed high agreement for total handwriting scores and letter size, as well as speed and legibility scores, whereas there were mixed levels of inter-rater reliability for other handwriting measures. Overall handwriting quality (p = 0.001) and legibility (p = 0.009) significantly improved, while letter size (p = 0.012), fluency (p = 0.001), regularity of letter size (p = 0.009), and straightness of lines (p = 0.036) were also enhanced. Conclusions The results of this study show that this 6-week intensive remotely-monitored physiotherapy-led handwriting programme improved handwriting in PwP. This is the first study of its kind to use this tool remotely, and it demonstrated that the SOS-PD is reliable for measuring handwriting in PwP.

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Section: Introductionmentioning

confidence: 99%

Intensive training programme improves handwriting in a community cohort of people with Parkinson’s disease

Collins,

Roberts,

Cleary

et al. 2023

Ir J Med Sci

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A literature review of online handwriting analysis to detect Parkinson’s disease at an early stage

Aouraghe¹,

Khaissidi²,

Mrabti³

2022

Multimed Tools Appl

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Parkinson’s Disease - Functional Movement Battery (PD-FUNC): a simple tool to objectively evaluate functional movement capacity of patients with Parkinson’s disease

Smits-Engelsman,

Duysens

2024

Preprint

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Clinicians require quantitative measures of functional movement to inform care decisions for persons with Parkinson’s disease (PWPs). To address this need, we developed the Parkinson’s Disease - Functional Movement Battery (PD-FUNC), which includes valid items from existing assessments and evaluates five key areas from the MDS-UPDRS-III: manual dexterity, functional strength, locomotion, static balance, and activities of daily living. This study assessed the PD-FUNC’s ability to distinguish between PWPs and healthy controls based on effect sizes and analyzed differences according to disease progression using years since diagnosis and MDS-UPDRS-III scores, as well as Hoehn & Yahr (H&Y) stages. The test was administered to 81 PD patients (H&Y stages 1–3) and 81 age-matched controls. All items, except grip force, discriminated effectively, with dexterity tasks showing the highest sensitivity (effect size r = 0.52–0.63). The PD-FUNC distinguished PD stages well, revealing early symptoms through dexterity tests (p = 0.001) and late-stage symptoms via dynamic stability tests. The PD-FUNC provides a comprehensive assessment within 30–40 minutes and could be used to evaluate disease progression and medication effectiveness at home and in clinical settings.

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Levodopa improves handwriting and instrumental tasks in previously treated patients with Parkinson’s disease

Cited by 3 publications

References 33 publications

Intensive training programme improves handwriting in a community cohort of people with Parkinson’s disease

Intensive training programme improves handwriting in a community cohort of people with Parkinson’s disease

A literature review of online handwriting analysis to detect Parkinson’s disease at an early stage

Parkinson’s Disease - Functional Movement Battery (PD-FUNC): a simple tool to objectively evaluate functional movement capacity of patients with Parkinson’s disease

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