Levodopa in Acne Vulgaris

Burton, J.L.; Libman, L. J.; Hall, R.; Shuster, Sam

doi:10.1016/s0140-6736(71)90082-1

Cited by 18 publications

(3 citation statements)

References 11 publications

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“…They explained their failure to find any thyroxine rise in acute studies to the large size of the circulating thyroxine pool. We were unable to detect any evidence of release of TSH up to 105 min after the administra tion of L-dopa, nor did Burton et al [18], find any alteration in serum TSH level in normal subjects after up to 3 g daily of L-dopa for several weeks. However, these workers also reported no evidence of HGH release under these conditions, and it may be that the actual timing of the peak of HGH release is either dose dependant or varies with length of therapy.…”

Section: Discussioncontrasting

confidence: 67%

Effects of <i>L</i>-Dopa and Chlorpromazine on Human Growth Hormone and TSH Secretion in Normal Subjects and Acromegalics

et al. 1973

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Section: Discussioncontrasting

confidence: 67%

Effects of <i>L</i>-Dopa and Chlorpromazine on Human Growth Hormone and TSH Secretion in Normal Subjects and Acromegalics

et al. 1973

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“…The mechanisms of L-dopa and bromocriptine suppressive effects on the sebum secretion are presently unknown. A direct suppression of the sebaceous gland seems unlikely as L-dopa is unable to decrease the' elevated sebum secretion from sebaceous glands of patients with acne (19).…”

Section: Discussionmentioning

confidence: 99%

Sebum secretion in idiopathic Parkinson's disease: effect of anticholinergic and dopaminergic drugs

Villares

Carlini

1989

Acta Neurologica Scandinavica

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Sebum secretion was measured on the foreheads of 47 unmedicated patients with idiopathic Parkinson's disease, aged 50-81 years and 80 healthy, matched volunteers. Sebum secretion was significantly higher in men patients aged 50-59 years than in controls; no such difference was observed in women of the same age. There was also no difference between patients and volunteers of either gender older than 60 years of age. The effects of either biperiden, L-Dopa + benserazide (a decarboxylase inhibitor) or bromocriptine treatments on sebum secretion and on 5 parkinsonian signs were evaluated over 127 days. There was a significant reduction of all measures during the treatment with the dopaminergic drugs. The only observable effect with biperiden was reduction of tremor. It is discussed whether the sebum suppressive effect of the dopaminergic drugs may be explained through their central effects.

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“…We have also shown that L-dopa has no effect on the SER of normal rats (Thody & Shuster, unpublished) or human subjects with severe acne (Burton et al, 1971). It appears therefore that L-dopa decreases sebum excretion only where there is a specific abnormality of sebaceous gland control.…”

Section: Discussionmentioning

confidence: 86%

Effect of L-dopa on the seborrhoea of Parkinsonism

Burton¹,

Cartlidge²,

Shuster³

1973

Br J Dermatol

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Summary By studying the sebum excretion rate in patients with Parkinsonism before and during treatment with L‐dopa we have shown that L‐dopa reduces sebum excretion if seborrhoea is initially present, but has no effect on normal sebum excretion rates. The seborrhoea of Parkinsonism may be due to increased production of melanocyte‐stimulating hormone, and our finding may have therapeutic implications in Parkinsonism and breast cancer.

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Levodopa in Acne Vulgaris

Cited by 18 publications

References 11 publications

Effects of <i>L</i>-Dopa and Chlorpromazine on Human Growth Hormone and TSH Secretion in Normal Subjects and Acromegalics

Effects of <i>L</i>-Dopa and Chlorpromazine on Human Growth Hormone and TSH Secretion in Normal Subjects and Acromegalics

Sebum secretion in idiopathic Parkinson's disease: effect of anticholinergic and dopaminergic drugs

Effect of L-dopa on the seborrhoea of Parkinsonism

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