Levodopa-responsive parkinsonism and autonomic (small fiber) dysfunction in patients with Wilson'/INS;s disease (WD)

Gondim, Francisco de Assis Aquino; Oliveira, Ítalo; Araújo, Davi Farias de; Melo, Alan Peres Ferraz de; Alves, Luiza Clertiani Vieira; Araújo, Ineusi Teixeira de; Vale, Otoni Cardoso do

doi:10.1016/j.jns.2013.07.2448

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dopaminergic treatment (levodopa, ropinirole, apomorphine) was administrated to a few WD cases and in case series reports. [40][41][42][43][44][45] A majority of reports showed no effect of dopaminergic drugs. However, due to the proven dopaminergic neurotransmission failure in patients with WD and the low prevalence of adverse reactions to dopaminergic treatment, we suggest that dopaminergic compounds should be tried in patients with WD to treat dystonia and parkinsonism.…”

Section: [32]mentioning

confidence: 99%

Neurological manifestations in Wilson’s disease –possible treatment options for symptoms

Litwin

Dušek²,

Członkowska

2016

Expert Opinion on Orphan Drugs

View full text Add to dashboard Cite

Section: [32]mentioning

confidence: 99%

Neurological manifestations in Wilson’s disease –possible treatment options for symptoms

Litwin

Dušek²,

Członkowska

2016

Expert Opinion on Orphan Drugs

View full text Add to dashboard Cite

Tackling the neurological manifestations in Wilson’s disease – currently available treatment options

Litwin,

Dusek,

Antos

et al. 2023

Expert Review of Neurotherapeutics

View full text Add to dashboard Cite

Small (autonomic) and large fiber neuropathy in Parkinson disease and parkinsonism

et al. 2016

View full text Add to dashboard Cite

BackgroundRecent studies have reported that peripheral neuropathy (PN) is common in patients with Parkinson’s disease (PD) and raised the possibility that levodopa neurotoxicity is the main culprit.MethodsWe evaluated the presence of large & small (autonomic) fiber PN in 54 consecutive patients with PD or parkinsonism in a tertiary outpatient clinic from Brazil. Initial PN screening consisted of history/neurological exam and skin wrinkling test (SWT). In addition, we also performed Nerve conduction studies/Electromyography (NCS/EMG) in all patients with PN signs/symptoms and/or abnormal SWT.ResultsThirty eight patients with PD (10 women, mean age: 63 ± 2.1 years, P < 0.05 versus parkinsonism, mean disease duration: 8 ± 0.8 years) and 16 patients with other forms of parkinsonism [7 women, mean age: 50.1 ± 3.9 years, mean disease duration: 6.9 ± 1.1 years] completed clinical neuromuscular evaluation. SWT was performed in 48 patients (33 PD, 15 parkinsonism). In the PD group, SWT was abnormal in 57.6 % of the tested patients (comprising 50 % of all PD patients). In the parkinsonism group, SWT was abnormal in 37.5 % (comprising 35.3 % of all parkinsonism patients). NCS/EMG was performed in 39 patients (26 PD and 13 parkinsonism). Twelve out of the 26 PD (34.2 % of all PD) and 4 out of the 13 parkinsonism (23.5 % of all parkinsonism) had abnormal NCS/EMG results. Neuropathy prevalence was similar in PD and parkinsonism groups as detected either by NCS/EMG or SWT.ConclusionsLarge fiber and small (autonomic) fiber PN are common in patients with PD and parkinsonism. The etiology for the neuropathy was likely to be multifactorial and may be secondary to PD itself.Electronic supplementary materialThe online version of this article (doi:10.1186/s12883-016-0667-3) contains supplementary material, which is available to authorized users.

show abstract

Levodopa-responsive parkinsonism and autonomic (small fiber) dysfunction in patients with Wilson'/INS;s disease (WD)

Cited by 3 publications

References 0 publications

Neurological manifestations in Wilson’s disease –possible treatment options for symptoms

Neurological manifestations in Wilson’s disease –possible treatment options for symptoms

Tackling the neurological manifestations in Wilson’s disease – currently available treatment options

Small (autonomic) and large fiber neuropathy in Parkinson disease and parkinsonism

Contact Info

Product

Resources

About