Levofloxacin-based carbon dots to enhance antibacterial activities and combat antibiotic resistance

“…Wu et al [ 157 ] reported that the levofloxacin (antibiotic medicine)-based carbon dots (LCDs) improved the antibacterial activity and reduced drug resistance. The results showed that LCDs have effective antibacterial properties due to the active groups of levofloxacin being preserved.…”

Section: Applications Of Cdsmentioning

confidence: 99%

“… Photographic images of the wound healing progress (1 to 10 days) of ( A ) the infected wounds with S. aureus and ( B ) infected wounds with E. coli treatment with normal saline, LC-HCl, and LCDs (reprinted with permission from [ 157 ], 2022, Elsevier). …”

Section: Figurementioning

confidence: 99%

Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

Pundi

Chang

2022

Polymers

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Although there is significant progress in the research of carbon dots (CDs), some challenges such as difficulty in large-scale synthesis, complicated purification, low quantum yield, ambiguity in structure-property correlation, electronic structures, and photophysics are still major obstacles that hinder the commercial use of CDs. Recent advances in synthesis, modification, characterization, and applications of CDs are summarized in this review. We illustrate some examples to correlate process parameters, structures, compositions, properties, and performances of CDs-based materials. The advances in the synthesis approach, purification methods, and modification/doping methods for the synthesis of CDs are also presented. Moreover, some examples of the kilogram-scale fabrication of CDs are given. The properties and performance of CDs can be tuned by some synthesis parameters, such as the incubation time and precursor ratio, the laser pulse width, and the average molar mass of the polymeric precursor. Surface passivation also has a significant influence on the particle sizes of CDs. Moreover, some factors affect the properties and performance of CDs, such as the polarity-sensitive fluorescence effect and concentration-dependent multicolor luminescence, together with the size and surface states of CDs. The synchrotron near-edge X-ray absorption fine structure (NEXAFS) test has been proved to be a useful tool to explore the correlation among structural features, photophysics, and emission performance of CDs. Recent advances of CDs in bioimaging, sensing, therapy, energy, fertilizer, separation, security authentication, food packing, flame retardant, and co-catalyst for environmental remediation applications were reviewed in this article. Furthermore, the roles of CDs, doped CDs, and their composites in these applications were also demonstrated.

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“…Antimicrobial CDs have also been developed by using traditional antibiotics and common antibacterial compounds as the raw materials to trade the old for the new, such as kanamycin sulfate [ 72 ], levofloxacin hydrochloride [ 73 , 74 ], quaternary ammonium compounds [ 22 , 48 , 49 , 75 , 76 ], and 2,4-dihydroxybenzoic acid [ 77 ]. Luo et al prepared CDs (termed CDs-Kan) from kanamycin sulfate by a one-step hydrothermal method [ 72 ].…”

Section: Antimicrobial Cdsmentioning

confidence: 99%

Carbon Dots for Killing Microorganisms: An Update since 2019

Lin

Wang

2022

Pharmaceuticals

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Frequent bacterial/fungal infections and occurrence of antibiotic resistance pose increasing threats to the public and thus require the development of new antibacterial/antifungal agents and strategies. Carbon dots (CDs) have been well demonstrated to be promising and potent antimicrobial nanomaterials and serve as potential alternatives to conventional antibiotics. In recent years, great efforts have been made by many researchers to develop new carbon dot-based antimicrobial agents to combat microbial infections. Here, as an update to our previous relevant review (C 2019, 5, 33), we summarize the recent achievements in the utilization of CDs for microbial inactivation. We review four kinds of antimicrobial CDs including nitrogen-doped CDs, metal-containing CDs, antibiotic-conjugated CDs, and photoresponsive CDs in terms of their starting materials, synthetic route, surface functionalization, antimicrobial ability, and the related antimicrobial mechanism if available. In addition, we summarize the emerging applications of CD-related antimicrobial materials in medical and industry fields. Finally, we discuss the existing challenges of antimicrobial CDs and the future research directions that are worth exploring. We believe that this review provides a comprehensive overview of the recent advances in antimicrobial CDs and may inspire the development of new CDs with desirable antimicrobial activities.

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Levofloxacin-based carbon dots to enhance antibacterial activities and combat antibiotic resistance

Cited by 76 publications

References 48 publications

Silver nanoparticle@carbon quantum dot composite as an antibacterial agent

Silver nanoparticle@carbon quantum dot composite as an antibacterial agent

Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

Carbon Dots for Killing Microorganisms: An Update since 2019

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