Levofloxacin implants with predefined microstructure fabricated by three-dimensional printing technique

Huang, Weidong; Zheng, Qiang; Sun, WaiChing; Xu, Huibi; Yang, Xiangliang

doi:10.1016/j.ijpharm.2007.02.021

Cited by 143 publications

(74 citation statements)

References 18 publications

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“…1b). PB 3D printing has expanded into areas such as tissue engineering and pharmaceutical applications over a decade between 1993 to 2003 leading to its use in the manufacturing of implants (54) and oral dosage forms (36,55).…”

Section: A Stereolithographic 3d Printing (Sla)mentioning

confidence: 99%

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

et al. 2016

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The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such as extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, including design flexibility and control and manufacture which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.

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Section: A Stereolithographic 3d Printing (Sla)mentioning

confidence: 99%

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

et al. 2016

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“…December 1996 and since then has been essentially used in broad pharmaceutical applications such as in oral administration 284 .…”

Section: It Was Discovered In 1962 and Approved By The Food Drug Admimentioning

confidence: 99%

Polyelectrolyte complex materials from chitosan and gellan gum

Amin

Panhuis

2011

Carbohydrate Polymers

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“…Various techniques for drug administration and delivery devices including solid dosage forms, 26 implantable drug delivery vehicles, 23,33 and topical drug delivery systems 25 could benefit from what AM has to offer. The recent approval of an AM drug product by the FDA in August 2015 49 marked the beginning of an era where more additively manufactured drugs are expected to enter routine clinical use.…”

Section: Drugs and Drug Deliverymentioning

confidence: 99%

Additive Manufacturing of Biomaterials, Tissues, and Organs

2016

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Abstract-The introduction of additive manufacturing (AM), often referred to as three-dimensional (3D) printing, has initiated what some believe to be a manufacturing revolution, and has expedited the development of the field of biofabrication. Moreover, recent advances in AM have facilitated further development of patient-specific healthcare solutions. Customization of many healthcare products and services, such as implants, drug delivery devices, medical instruments, prosthetics, and in vitro models, would have been extremely challenging-if not impossible-without AM technologies. The current special issue of the Annals of Biomedical Engineering presents the latest trends in application of AM techniques to healthcare-related areas of research. As a prelude to this special issue, we review here the most important areas of biomedical research and clinical practice that have benefited from recent developments in additive manufacturing techniques. This editorial, therefore, aims to sketch the research landscape within which the other contributions of the special issue can be better understood and positioned. In what follows, we briefly review the application of additive manufacturing techniques in studies addressing biomaterials, (re)generation of tissues and organs, disease models, drug delivery systems, implants, medical instruments, prosthetics, orthotics, and AM objects used for medical visualization and communication.

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Levofloxacin implants with predefined microstructure fabricated by three-dimensional printing technique

Cited by 143 publications

References 18 publications

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

Polyelectrolyte complex materials from chitosan and gellan gum

Additive Manufacturing of Biomaterials, Tissues, and Organs

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