Levofloxacin in veterinary medicine: a literature review

Sitovs, Andrejs; Sartini, Irene; Giorgi, Mario

doi:10.1016/j.rvsc.2021.04.031

Cited by 31 publications

(14 citation statements)

References 132 publications

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“…16 On the other hand, due to the emerging resistance to first- and second-generation fluoroquinolones, 17 LEV has also been applied in veterinary medicine to support bacterial infection control and prophylactic purposes. 18 Meanwhile, inappropriate use of LEV can lead to cardiovascular, respiratory, and gastrointestinal damage. 19…”

Section: Introductionmentioning

confidence: 99%

“…16 On the other hand, due to the emerging resistance to rstand second-generation uoroquinolones, 17 LEV has also been applied in veterinary medicine to support bacterial infection control and prophylactic purposes. 18 Meanwhile, inappropriate use of LEV can lead to cardiovascular, respiratory, and gastrointestinal damage. 19 Different strategies for the development of low-cost devices used for LEV monitoring have been addressed in the literature, such as pencil graphite electrodes, 20,21 screen-printed electrodes, 22 carbon paste electrodes, 23,24 and 3D-printed electrodes.…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical monitoring of levofloxacin using a silver nanoparticle-modified disposable device based on a lab-made conductive ink

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrochemical monitoring of levofloxacin using a silver nanoparticle-modified disposable device based on a lab-made conductive ink

et al. 2023

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“…Levofloxacin is being used in both human and veterinary medicine (Sitovs et al, 2021). In some countries, such as Argentina, China and India, veterinary levofloxacin formulations are approved for dogs, cattle, pigs and poultry (Sitovs et al, 2021), but not rabbits. In the EU and the USA, levofloxacin is not currently labelled for veterinary use.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, low levels of resistance to fluoroquinolones were reported in P. multocida isolates (EFSA Panel on Animal Health and Welfare (AHAW) et al, 2021; Gardhouse et al, 2017; Jekl, 2021; Wang et al, 2019). Escherichia coli resistance to fluoroquinolones, including levofloxacin, was reported in animals (Marco‐Fuertes et al, 2022; Sitovs et al, 2021). Levofloxacin is being used in both human and veterinary medicine (Sitovs et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

In vitro and ex vivo antibacterial activity of levofloxacin against Pasteurella multocida and Escherichia coli isolated from rabbits (Oryctolagus cuniculus) – A preliminary study

Sitovs

Skadiņš

Purvina

et al. 2023

Vet Pharm & Therapeutics

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Levofloxacin veterinary formulations are available in Argentina, China and India for the use in dogs, cattle, pig and sheep, but not currently in the rabbit. Only the extra‐label use in rabbits is possible. Levofloxacin is not labelled for veterinary use in the EU or the USA. The activity of levofloxacin against rabbit pathogens Pasteurella multocida (P. multocida) and Escherichia coli (E. coli) was evaluated. Minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were determined in broth and serum for 10 P. multocida isolates and 5 E. coli isolates from rabbits. One isolate of each bacterial species was used for the time‐killing curve study in vitro and ex vivo. In vitro AUC24/MIC ratios were used for building the inhibitory pharmacodynamic Imax model. The P. multocida MIC were 0.008–0.5 μg/mL, MBC – 0.015–0.5 μg/mL. Escherichia coli MIC was 0.008–0.03 μg/mL and MBC – 0.03–0.25 μg/mL. Bacterial counts were reduced to the limit of detection after 24 h with levofloxacin concentrations of 2 MIC and higher. All serum samples from rabbits treated with levofloxacin eliminated the bacteria within 24 h. AUC24/MIC ratios for bacteriostatic, bactericidal and bacterial elimination effects for P. multocida and E. coli isolates were 21, 29 and 75 h and 27, 32 and 60 h, respectively. Proposed daily doses against P. multocida (MIC = 0.015 μg/mL) and E. coli (MIC = 0.03 μg/mL) isolates were calculated as ≤0.91 and ≤1.43 mg/kg, respectively. Fluoroquinolones are categorized by WHO as ‘highest priority critically important antimicrobials’. Considering the increasing importance of antimicrobial stewardship, antimicrobials from a lower importance category that are active against the isolate of interest should be used in preference to fluoroquinolones. Fluoroquinolone use in veterinary medicine should be based on antimicrobial susceptibility testing in order to mitigate the risk to public health and prevent the spread of bacterial resistance.

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“…Levofloxacin is an antimicrobial agent used in humans but is also used in animals in many countries [ 17 ]. To date, the susceptibility of T. pyogenes to levofloxacin has not been reported in livestock strains.…”

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confidence: 99%

Antimicrobial susceptibility of <i>Trueperella pyogenes</i> isolated from cattle and pigs with septicemia in southern Kyushu, Japan

Fujimoto¹,

Nakamura²,

Sato³

et al. 2023

The Journal of Veterinary Medical Science

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We investigated the antimicrobial susceptibility of Trueperella pyogenes isolates from cattle and pigs diagnosed with septicemia at slaughter. The strains investigated in this study were found to be susceptible to ampicillin, cefazolin, gentamicin, and levofloxacin. However, 53.3% of the strains were resistant to tetracycline, 49.7% to streptomycin, 13.8% to erythromycin, 13.2% to clindamycin, and 1.2% to oxacillin and kanamycin. We also found that the resistance of pig-derived strains of T. pyogenes to tetracycline, streptomycin, erythromycin, and clindamycin was higher than that of cattle-derived strains, and these strains were resistant to up to four antimicrobial agents used simultaneously. The present results provide new data on the range of the minimum inhibitory concentration (MIC) values of various antimicrobial agents for T. pyogenes isolated from livestock with septicemia. The breakpoint values used in this study are generally considered applicable.

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Levofloxacin in veterinary medicine: a literature review

Cited by 31 publications

References 132 publications

Electrochemical monitoring of levofloxacin using a silver nanoparticle-modified disposable device based on a lab-made conductive ink

Electrochemical monitoring of levofloxacin using a silver nanoparticle-modified disposable device based on a lab-made conductive ink

In vitro and ex vivo antibacterial activity of levofloxacin against Pasteurella multocida and Escherichia coli isolated from rabbits (Oryctolagus cuniculus) – A preliminary study

Antimicrobial susceptibility of <i>Trueperella pyogenes</i> isolated from cattle and pigs with septicemia in southern Kyushu, Japan

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