Levofloxacin in vitro activity and time-kill evaluation of Stenotrophomonas maltophilia clinical isolates

Abstract

The in vitro activity of levofloxacin and eight other antimicrobial agents against 60 clinical isolates of Stenotrophomonas maltophilia was determined by an agar dilution method using 10(4) and 10(6) cfu/spot inocula. At the lower inoculum, 85.0% of the isolates were susceptible to levofloxacin but only 58.3% were susceptible to ofloxacin; at the higher inoculum, 78.3% were susceptible to levofloxacin and 36.7% to ofloxacin. In time-kill studies, levofloxacin exerted bactericidal activity within 4 h. With ofloxacin and ciprofloxacin bacterial regrowth was observed after 8 h. Levofloxacin may represent an alternative drug in the treatment of infections caused by S. maltophilia.

Combination Antimicrobial Susceptibility Testing of Multidrug-Resistant Stenotrophomonas maltophilia from Cystic Fibrosis Patients

“…Co-trimoxazole, ticarcillin/clavulanate, minocycline, doxycycline, levofloxacin, and chloramphenicol have all been reported as being the most active single agent against S. maltophilia isolated from individuals with and without CF (6,9,11,18,22,27,29). Co-trimoxazole is often the drug of first choice for therapy, although increasing in vitro resistance is being reported (2,9,14). Of the patients in our study, 24.2% had co-trimoxazole-resistant S. maltophilia, and, like Valdezate et al, we also found a bimodal distribution of MICs (29).…”

Stenotrophomonas maltophilia Bacteraemia: Analysis of 33 Episodes Occurred in the ICU at the University Hospital in Sousse, Tunisia

“…Indeed, in Spain, Canada and Latin America, authors reported that 2% of isolates of S. maltophilia were resistant to SXT [53] [54] [49], 10% in Europe [49]. Whereas an Italian study reported the highest levels of resistance reached 80.9% of the isolates [55]. Table 5.…”

Hastane İnfeksi̇yon Etkeni̇ Olarak İzole Edi̇len Non-Fermentati̇f Gram Negati̇f Bakteri̇lerde Si̇profloksasi̇n, Ofloksasi̇n Ve Levofloksasi̇ni̇n i̇n-Vi̇tro Etki̇nli̇ği̇ni̇n Karşilaştirilmasi

“…S. maltophilia'nın etken olduğu infeksiyonlarda kinolonlar tek başlarına ya da diğer antibiyotiklerle kombinasyon yapılarak tedavi alternatifi olmuşlardır (17). Kinolonların bu bakteriye etkinliğinin araştırıldığı çalışmalarda siprofloksasine oldukça değişken duyarlılık oranları (%25-79) bildirilmekte (7,11) ve yeni kinolonların (levofloksasin, moksifloksasin, klinafloksasin gibi) daha iyi in-vitro aktiviteye sahip olduğu belirtilmektedir (1,12,17,18). Schmitz (11) ve Hoban'ın (19) çalışmalarında ise bu bakterinin levofloksasin ve ofloksasine siprofloksasinden daha yüksek duyarlılık oranlarına sahip olduğu gösterilmiştir.…”