Levofloxacin-Induced Toxic Epidermal Necrolysis

Abstract

Toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, is a severe episodic mucocutaneous reaction that is usually brought on by oral medications and/or sporadically by infections. We report a case of a 19-year-old male with the presenting complaint of generalized skin blistering over the previous seven days at the dermatology outpatient clinic. The patient has had epilepsy since he was 10 years old. Due to an upper respiratory tract illness, a local healthcare facility recommended oral levofloxacin to him seven days ago. Levofloxacin-induced toxic epidermal necrolysis (TEN) was suspected based on the patient's medical history, physical examination, and research. On the basis of histological investigations and clinical correlation, the diagnosis of TEN was determined. The mainstay of treatment after diagnosis was made was supportive care. The best methods for treating TEN involve stopping any potential causal agents and providing supportive care. The patient received care in the intensive care unit.

The First Documented Ibuprofen-Induced Toxic Epidermal Necrolysis in the Middle East and North Africa Region: A Case Report, Complications, and Management

“…Finally, given that the cases of TEN are relatively scarce in the literature, no definitive therapeutic modalities have been shown to be of proven efficacy, and the use of corticosteroids and intravenous immunoglobulin, among other therapeutic approaches, is still grossly based on observational studies [19]. However, we strongly believe, as supported by the literature [20], that early hospitalization, with supportive management, hydration, and nutritional support had a major role in reducing the mortality and morbidity in our patient.…”