Levonorgestrel-releasing intrauterine device insertion ameliorates leiomyoma-dependent menorrhagia among women of reproductive age without a significant regression in the uterine and leiomyoma volumes

Comparison of levonorgestrel intrauterine system versus hysterectomy on efficacy and quality of life in patients with adenomyosis

“…Although this rate is considerably higher than that in the study by Fedele et al (15), it is consistent with the other previous reports. Very recently, Naki et al reported an almost 60% amenorrhea incidence at the sixth month of follow-up in leiomyoma-dependent menorrhagia (18). LNG-IUS is hypothesized to work on adenomyosis in two ways.…”

Medical Treatment of Fibroid to Decrease Rate of Hysterectomy

“…In a small randomized trial; LNG decreased the blood loss significantly after 6 weeks of application in women with menorrhagia and fibroid [15]. However; it did not decrease the myoma size.…”

Levonorgestrel intrauterine contraceptive device in heavy menstrual bleeding: our experience in a tertiary level government hospital

“…In contrast to this, Magal Haes et al found significant change in leiomyoma volume after 3 years. [14][15][16][17] Patients with anovulatory cycles suffer from loss of progesterone effect on the endometrium leading to proliferation of endometrium due to unopposed action of estrogen. Also, the recent theory suggests that the absence of progesterone results in reduced endometrial stromal cell factor, reduced plasminogen activator inhibitor-1 production, increased matrix metalloproteinase activity and increased angiogenic factor expression.…”