Levormeloxifene inhibits vaginal tropoelastin and transforming growth factor beta 1 production

Pelvic organ prolapse (POP) is a prevalent and disabling condition. The pathophysiology of prolapse is multifactorial, and no single mechanism adequately explains all aspects of its development. The pathophysiology of POP is complex and incompletely understood. Smooth muscle (SM), an integral part of the vaginal wall and endopelvic structures that support the pelvic viscera, has also been implicated in the pathophysiology of POP. In this article, we review the role of smooth muscle cells (SMC) in the pathophysiology of POP, also addressing the anatomy of SM in pelvic floor, morphometric analysis, biomechanical properties, and potential mechanisms.

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Levormeloxifene inhibits vaginal tropoelastin and transforming growth factor beta 1 production

Abstract: Purpose: To measure the effects of levormeloxifene on vaginal smooth muscle cell (SMC) proliferation, tropoelastin and transforming growth factor (TGF)-1 production. Methods

Cited by 3 publications

References 30 publications

Estrogen inhibits vaginal tropoelastin and TGF-β1 production

Estrogen inhibits vaginal tropoelastin and TGF-β1 production

Pelvic organ prolapse: from estrogen to pessary

The Role of Smooth Muscle Cells in the Pathophysiology of Pelvic Organ Prolapse

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