Levothyroxine dosages during pregnancy among hypothyroid women. An experience from a tertiary care center of Karachi, Pakistan, based on data from Maternal Hypothyroidism on Pregnancy Outcomes Study (MHPO-5)

Kiran, Zareen; Khalid, Wardah; Sheikh, Aisha; Islam, Najmul

doi:10.1186/s13104-022-05984-7

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…However, both high and low maternal FT4 concentrations are associated with lower child IQ, suggesting that overcorrection of maternal hypothyroidism may itself have adverse effects ( 44 ). In recent years, progress has been made regarding the safety of thyroid hormone replacement therapy, including studies on different dosages ( 104 , 105 ). Research also emphasizes adjusting thyroid hormone dosage and administration methods based on the specific circumstances of patients ( 106 ).…”

Section: Discussionmentioning

confidence: 99%

Emerging research themes in maternal hypothyroidism: a bibliometric exploration

Chen,

Luo,

Zhang

et al. 2024

Front. Immunol.

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BackgroundHypothyroidism, a prevalent endocrine disorder, carries significant implications for maternal and infant health, especially in the context of maternal hypothyroidism. Despite a gradual surge in recent research, achieving a comprehensive understanding of the current state, focal points, and developmental trends in this field remains challenging. Clarifying these aspects and advancing research could notably enhance maternal-infant health outcomes. Therefore, this study employs bibliometric methods to systematically scrutinize maternal hypothyroidism research, serving as a reference for further investigations.ObjectiveThrough bibliometric analysis, this study seeks to unveil key research focus areas, developmental trends, and primary contributors in Maternal Hypothyroidism. The findings offer insights and recommendations to inform future research endeavors in this domain.MethodsLiterature metrics analysis was performed on data retrieved and extracted from the Web of Science Core Collection database. The analysis examined the evolution and thematic trends of literature related to Maternal Hypothyroidism. Data were collected on October 28, 2023, and bibliometric analysis was performed using VOSviewer, CiteSpace, and the Bibliometrix software package, considering specific characteristics such as publication year, country/region, institution, authorship, journals, references, and keywords.ResultsRetrieved from 1,078 journals, 4,184 articles were authored by 18,037 contributors in 4,580 institutions across 113 countries/regions on six continents. Maternal Hypothyroidism research publications surged from 44 to 310 annually, a 604.54% growth from 1991 to 2022. The USA (940 articles, 45,233 citations), China Medical University (82 articles, 2,176 citations), and Teng, Weiping (52 articles, 1,347 citations) emerged as the most productive country, institution, and author, respectively. “Thyroid” topped with 233 publications, followed by “Journal of Clinical Endocrinology & Metabolism” (202) with the most citations (18,513). “Pregnancy” was the most cited keyword, with recent high-frequency keywords such as “outcome,” “gestational diabetes,” “iodine intake,” “preterm birth,” “guideline,” and “diagnosis” signaling emerging themes in Maternal Hypothyroidism.ConclusionsThis study unveils developmental trends, global collaboration patterns, foundational knowledge, and emerging frontiers in Maternal Hypothyroidism. Over 30 years, research has predominantly focused on aspects like diagnosis, treatment guidelines, thyroid function during pregnancy, and postpartum outcomes, with a central emphasis on the correlation between maternal and fetal health.

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Section: Discussionmentioning

confidence: 99%

Emerging research themes in maternal hypothyroidism: a bibliometric exploration

Chen,

Luo,

Zhang

et al. 2024

Front. Immunol.

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“…Various reports suggest a 30% increase in the pre-pregnancy levothyroxine dose as sufficient for optimization of thyroid function (Kiran et al, 2022). Increases in levothyroxine dosage administered in pregnancy is indispensable in the majority of patients although the patient is euthyroid.…”

Section: Discussionmentioning

confidence: 99%

Levothyroxine in Women with Clinical Hypothyroidism Undergoing In-Vitro Fertilization: A Case Report

Alrifai¹,

Melhem²,

Hazimeh³

2022

FMCR

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Hypothyroidism is characterized by a high thyroid stimulating hormone (TSH) level and low thyroid hormones (T3 and/or T4). Abnormalities in ovulation, infertility, and recurrent pregnancy losses can arouse due to hypothyroidism. Pregnancy is a physiological status that mandates an increase in levothyroxine doses for euthyroid women with primary hypothyroidism. Serum levels of thyroid stimulating hormone can increase significantly during In-Vitro fertilization among women treated for hypothyroidism, and hypothyroidism that is either undiagnosed or under-treated can contribute to infertility and result in miscarriages. Throughout the literature, artificial pregnancies, In-Vitro fertilization (IVF) mainly, have required a more aggressive increase in the levothyroxine dose. Here, we report the case of a 40-year old hypothyroid woman with a history of nine abortions after IVF procedures who presented for treatment of her hypothyroidism. We present in details the modification process of her levothyroxine dose according to monthly TSH levels starting from her ninth miscarriage through her tenth IVF procedure and all throughout the pregnancy, until the successful delivery of a healthy baby.

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