Lewis acid catalyzed rapid synthesis of 5-hydroxy-benzo[g]indole scaffolds by a modified Nenitzescu reaction

Synthesis and Cytotoxic Activity Study of Novel 2-(Aryldiazenyl)-3-methyl-1H-benzo[g]indole Derivatives

“…These limitations in cancer chemotherapy using the currently available drugs encourage drug discovery researchers to find new efficient chemotherapeutic agents for cancer treatment [2]. Nitrogen-containing heterocyclic compounds are a class of compounds that have recently attracted an increased interest within the pharmaceutical community due to their widespread and often diverse biological activities [3]. The indolebased compounds in particular are common building blocks for many medicinally active drugs and are considered as target pharmacophores for the development of therapeutic agents [4][5][6][7][8][9].…”

Nenitzescu Synthesis of 5‐Hydroxyindoles with Zinc, Iron and Magnesium Salts in Cyclopentyl Methyl Ether

“…[24] Interestingly BF 3diethyl etherate, with an excess of urea, has been applied to a modified version of Nenitzescu synthesis assisted by microwaves. [25] These methods have some drawback on the environmental impact side, because all of them use solvents at reflux and some of them require the use of chlorinated solvents, [21,22,24] chromatographic purification [23,24] and for some substrate stoichiometric amounts of Lewis acids [22] or additives. [25]…”

“…[25] These methods have some drawback on the environmental impact side, because all of them use solvents at reflux and some of them require the use of chlorinated solvents, [21,22,24] chromatographic purification [23,24] and for some substrate stoichiometric amounts of Lewis acids [22] or additives. [25]…”

Ultrasound‐Promoted Mild, and Efficient Protocol for Three‐Component Synthesis of 2,4,5‐Trisubstituted Imidazoles Using Urea and PPh3 as the Sources of Nitrogen and Organocatalyst

“…[38] Hereupon, the utility of urea as an eco-friendly source of ammonia for the chemical reaction has become the popular technique among the chemists, and in this regard plenty of reactions have been reported so far. For instance, primary amides, [39] pyrimidines, [40] 2,4,6-triarylpyridines, [41] 4-azasteroids, [42] fatty amides (erucamide) [43] and 5-hydroxy-benzo[g]indole scaffolds [44] were synthesized by decomposition of urea under microwave irradiation to access the required amine.…”