Lewy body dementias

Walker, Zuzana; Possin, Katherine L.; Boeve, Bradley F.; Aarsland, Dag

doi:10.1016/s0140-6736(15)00462-6

Cited by 479 publications

(404 citation statements)

References 160 publications

(166 reference statements)

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“…1 Pathological hallmarks of LBD include α-New knowledge added by this study • Behavioural and psychological symptoms of dementia were present in 83% of patients with Lewy body dementia (LBD).…”

Section: Introductionmentioning

confidence: 86%

A descriptive study of Lewy body dementia with functional imaging support in a Chinese population: a preliminary study

2017

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Section: Introductionmentioning

confidence: 86%

A descriptive study of Lewy body dementia with functional imaging support in a Chinese population: a preliminary study

2017

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“…A fokozott fizikai aktivitás javít-hatja a motoros funkciókat, csökkentve a parkinsonizmus tüneteit, fokozva az agyi vérátáramlást, ami kedvezően befolyásolhatja a kognitív zavarokat is [68]. Ortosztatikus hipotenzióban a magasabb sóbevitel, kompressziós harisnya viselése, valamint alvás során a fej megemelése az ágyban csökkenthetik a tüneteket [69]. Kiemelt jelentőségű a páciensek és hozzátartozóik pszichoterápiás vezetése, támogatása; a kognitív viselkedés-terápia hatásos lehet a depressziós és szorongásos tüne-tek kezelésében [70].…”

Section: Terápiás Megfontolásokunclassified

“…A mellékhatások tekintetében a donepezil tűnik jobban tolerálhatónak a két hatóanyag közül [72]. Ezeknél a szereknél leggyakrabban gastorintestinalis mellékhatá-sokkal kell számolni a paraszimpatikus idegrendszer fokozott aktivitása miatt, ugyanakkor ez előnyös lehet abban az esetben, ha az autonóm diszfunkció miatt obstipatio jelentkezik [69].…”

Section: Terápiás Megfontolásokunclassified

“…Ugyanakkor ez a mellékhatás kevésbé figyelhető meg PD és PDD esetén [9]. A pszichotikus tünetek kezelésében a nem típusos szerek közül a clozapinról van a legtöbb tapasztalat, azonban alkalmazását limitálja, hogy agranulocytosist okozhat, ezért a vérszintet folyamatosan monitorozni kell [69]. Mindemellett a clozapin antikolinerg mellékhatása az egyébként is jelen lévő kognitív tünetek-re negatív hatással lehet, illetve gyors dóziscsökkentés vagy -emelkedés delíriumot okozhat.…”

Section: Terápiás Megfontolásokunclassified

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A Lewy-testes demencia klinikai és neuropatológiai jellemzői

et al. 2017

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A Lewy-testes demencia a második leggyakoribb neurodegeneratív demencia. A pontos diagnózisa gyakran csak neuropatológiai vizsgálattal lehetséges. A betegség fő morfológiai jellemzője a kóros α-szinukleinben gazdag Lewy-test és Lewy-neurit -csakúgy, mint a rokon kórkép Parkinson-kór és az ahhoz társuló demencia esetén. A patomechanizmus fontos tényezői a neurotranszmitter rendszerek zavara, a szinaptikus diszfunkció és az ubikvitin-proteaszóma rendszer elégtelen működése. Jellemző a kognitív teljesítmény fluktuációja, parkinsonizmus és vizuális hallucináció. Mivel gyakran nem típusos a klinikai kép és időbeni lefolyás, a képalkotó eljárások és biomarkerek elősegíthetik a korai felismerést. Noha hatékony oki terápia nincs, életminőséget javító kezelések lehetségesek. A klinikopatológiai vizsgálatok kiemelten fontosak a patomechanizmus jobb megértése, a pontos diagnózis és a hatékony terápia érdeké-ben. Orv Hetil. 2017; 158(17): 643-652.Kulcsszavak: Lewy-testes demencia, neuropatológia, biomarkerek, Parkinson-kór, α-szinuklein Clinical and neuropathological characteristics of dementia with Lewy bodiesDementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. The accurate diagnosis is often possible only by neuropathological examination. The morphologic hallmarks are the presence of α-synuclein-rich Lewy bodies and Lewy neurites, identical to those seen in Parkinson's disease (PD) and Parkinson's disease dementia (PDD). Neurotransmitter deficits, synaptic and ubiquitin-proteasome system (UPS) dysfunction play major role in the pathomechanism. Characteristic symptoms are cognitive fluctuation, parkinsonism and visual hallucinations. Due to the often atypical clinical presentation novel imaging techniques and biomarkers could help the early diagnosis. Although curative treatment is not available, therapies can improve quality of life. Clinicopathological studies are important in exploring pathomechanisms, ensuring accurate diagnosis and identifying therapeutic targets.

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“…The following list shows the main categories of dementia as described by their 58 associated characteristics (Alzheimer's Association, 2016Khan, Kalaria, Corbett, & Ballard, 2016;Walker, Possin, Boeve, & Aarsland, 2015 Symptoms include decline in thinking and reasoning, involuntary muscular movements, confusion, difficulties walking and mood changes.…”

Section: Dementiamentioning

confidence: 99%

A methodological framework for exploring the applicability of virtual reality in cognitive disabilities care

Betances¹,

Isabel²

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There is always going to be a reason why you can't do something, your job is toconstantly look for the reasons why you can achieve your dreams. Shannon Miller -7x Olympic Gymnast medallist AcknowledgmentsI would like to firstly express my sincere gratitude to my advisor ProfessorMaría Teresa Arredondo Waldmeyer for her continuous support of my PhD studies and related research, and for her inspiration, tenacity, and immense knowledge.In addition to my advisor, I thank Prof. María Fernanda Cabrera-Umpiérrez and Prof. Francisco J. García-Sánchez, not only for their insightful commentaries and supportive encouragement, but also for the helpful suggestions and revision recommendations which motivated me to extend the scope of my research work to wider perspectives.I also thank my former colleagues and present fellow teammates at LifeSTech for the stimulating discussions, help and advice, as well as for the interesting times we shared working and learning together at several projects during the last years.Last but not least, I thank my family and friends for supporting all my life goals and purposes, and for the patience shown while I was writing this thesis.ix AbstractHandling the care needs of people affected by Alzheimer's disease and related dementias (ADRD) represents nowadays a personal, familial and social challenge of enormous proportions, which poses an ever growing human and economic burden on the world's society in general. Information and communication technologies (ICT) have the potential to make a considerable impact to help revert this trend, especially through the use of advanced virtual reality (VR)-based computerized diagnostic and therapeutic cognitive interventions for people living with, or at risk of developing,ADRD. This doctoral thesis aims to facilitate the use of such VR-based interventions.To that end, it makes specific original contributions regarding: the categorization of VR systems particularly designed for ADRD; an analysis and assessment of the current relevance and impact of the 'brain training debate' involving commercial brain training products; an up-to-date critical description of the technical and scientific challenges faced today for the development of effective VR-based cognitive training tools; and finally, this thesis proposes a novel methodological design framework to provide guidance to researchers and developers with the design process of VR-based tools to address the care needs of people with ADRD. The framework is based on our previous critical analysis of the most recent knowledge available about VR cognitive interventions. The framework and its ensuing roadmap take into account, not only universal design principles, standard techniques and methodologies, but also addresses the specific aspects of accessibility and usability that are particular to the use VR-based platforms on patients with ADRD-associated cognitive impairments.x xi ResumenEl manejo de las necesidades de atención de las personas afectadas por la enfermedad de Alzheimer y demencias relacionadas (EADR)...

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Lewy body dementias

Cited by 479 publications

References 160 publications

A descriptive study of Lewy body dementia with functional imaging support in a Chinese population: a preliminary study

A descriptive study of Lewy body dementia with functional imaging support in a Chinese population: a preliminary study

A Lewy-testes demencia klinikai és neuropatológiai jellemzői

A methodological framework for exploring the applicability of virtual reality in cognitive disabilities care

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