Leydig Cell Tumours: a Case Series from a Single Irish Centre

Bilateral congenital cryptorchidism and unilateral Leydig cell tumor in an adult presenting with gynecomastia and primary infertility: A case report

“…These tumors are usually associated with the deranged hormonal profile, attributing to the endocrine abnormalities commonly encountered with these tumors. High estrogen, high oestradiol, high luteinizing hormone (LH), high follicle-stimulating (FSH), and low testosterone levels are the most routinely hormonal changes seen upon workup [11] . Rusnak et al reported that patients with a history of bilateral cryptorchidism, have higher FSH levels and lower testosterone levels compared to those with unilateral cryptorchidism [12] .…”

“…As most cases follow a benign clinical course, adjuvant therapy is not usually warranted, except for the 2.5–15% of LCTs that behave aggressively [11] . Kim et al first described the six histopathological features of stromal tumors predictive of metastatic potential in 1985.…”