Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization

Huang, Shiyao; Kuri, Paola; Aubert, Yann; Brewster, Megan; Li, Ning; Farrelly, Olivia; Rice, Gabriella; Bae, Hyunjin; Prouty, Stephen M.; Dentchev, Tzvete; Luo, Wenqin; Capell, Brian C.; Rompolas, Panteleimon

doi:10.1016/j.stem.2021.05.007

Cited by 65 publications

(45 citation statements)

References 78 publications

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“…Our study highlights a novel and significant link between neuroregeneration and the restoration of progenitor cell identity in a model of chronic, autoimmune-mediated dry eye. Multiple studies in other organ systems, such as the salivary glands ( 63 ), tooth ( 64 ) and skin ( 65, 66 ), have established a critical role for nerves in the regulation of tissue structure, and function, as well as progenitor cell maintenance. In the cornea, mouse models of both chemically-and physically-induced denervation ( 67, 68 ) have implicated sensory innervation as a regulator of progenitor cell identity, as determined by a reduction in the expression of epithelial progenitor cell markers such as p63 ( 67 ), an outcome that can be partially reversed by topical NGF treatment ( 68 ).…”

Section: Discussionmentioning

confidence: 99%

A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration.

Efraim

Chen

Cheong

et al. 2022

Preprint

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Corneal architecture is essential for vision and is greatly perturbed by the absence of tears due to the highly prevalent disorder dry eye. With no regenerative therapies available, pathological alterations of the ocular surface in response to dryness, including persistent epithelial defects and poor wound healing, result in lifelong morbidity. Here, using a mouse model of aqueous-deficient dry eye, we reveal that topical application of the synthetic tear protein lacripep reverses the pathological outcomes of dry eye through restoring the extensive network of corneal nerves that are essential for tear secretion, barrier function, epithelial homeostasis and wound healing. Intriguingly, the restorative effects of lacripep occur despite extensive immune cell infiltration, suggesting tissue reinnervation and regeneration can be achieved under chronic inflammatory conditions. In summary, our data highlight lacripep as a first-in-class regenerative therapy for returning the cornea to a near homeostatic state in individuals who suffer from dry eye.

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Section: Discussionmentioning

confidence: 99%

A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration.

Efraim

Chen

Cheong

et al. 2022

Preprint

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“…However, the isthmus does contain a population of stem cells that can help to re-populate the epidermis during wound healing. Studies have identified a population of Gli1 + Lgr6 + cells in the isthmus which can contribute to formation of wound epithelium, and can provide a source of long-lasting epithelial precursors in healed epidermis ( Snippert et al, 2010 ; Huang S. et al, 2021 ). The bulge region is located at the junction of the APM and the ORS.…”

Section: Structure Of Hair Folliclesmentioning

confidence: 99%

Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles

Lin

Liang

2022

Front. Cell Dev. Biol.

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As one of the main appendages of skin, hair follicles play an important role in the process of skin regeneration. Hair follicle is a tiny organ formed by the interaction between epidermis and dermis, which has complex and fine structure and periodic growth characteristics. The hair growth cycle is divided into three continuous stages, growth (anagen), apoptosis-driven regression (catagen) and relative quiescence (telogen). And The Morphogenesis and cycle of hair follicles are regulated by a variety of signal pathways. When the signal molecules in the pathways are abnormal, it will affect the development and cycle of hair follicles, which will lead to hair follicle-related diseases.This article will review the structure, development, cycle and molecular regulation of hair follicles, in order to provide new ideas for solving diseases and forming functional hair follicle.

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“…Les facteurs régulant la contribution des différentes populations de cellules souches épidermiques à la cicatrisation ne sont pas complètement connus. Pour répondre à cette question, Huang et al ont utilisé des souris transgéniques exprimant des traceurs fluorescents dans des populations spécifiques de cellules souches et les ont suivis par des techniques d’imagerie 3D haute résolution in vivo [ 13 ]. Ils montrent qu’une population de cellules souches de l’IFE et de l’isthme, exprimant Leucine Rich-repeat Containing G Protein-coupled Receptor 6 (LGR6), contribue massivement à la réépithélialisation des plaies cutanées.…”

Section: De Nouveaux Mécanismes Régulateurs Des Cellules Souches De L’épidermeunclassified

Quoi de neuf en recherche 2021 ?

Nassar

2021

Annales de Dermatologie et de Vénéréologie - FMC

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Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization

Cited by 65 publications

References 78 publications

A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration.

A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration.

Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles

Quoi de neuf en recherche 2021 ?

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