Lhermitte's sign: Review with special emphasis in oncology practice

Gemici, Cengiz

doi:10.1016/j.critrevonc.2009.04.009

Cited by 23 publications

(15 citation statements)

References 66 publications

(199 reference statements)

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“…Neck flexion may then result in mechanical deformity of the exposed neurons and produce the characteristic electric shock-like symptom [1,7]. The mechanism by which cisplatin might induce LS is poorly understood.…”

Section: Discussionmentioning

confidence: 99%

“…Lossos et al [6] examined 42 cases of Lhermitte's in a cohort of oncology patients referred to a neuro-oncology clinic, and found 64% to be due to cisplatin. It has been suggested that LS is under-recognised and thus under-reported in oncology practice [1]. …”

Section: Discussionmentioning

confidence: 99%

“…It has also been referred to as barber chair sign [1]. LS was first described in 1917 related to cranial trauma and subsequently characterised by Jean Lhermitte in 1920 [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…However, LS as a complication of chemotherapy, as in our case, has been rarely reported. Most cases occur in association with cisplatin or oxaliplatin [1,3]. …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lhermitte's Phenomenon and Platinum, Beware of Latency

O’Reilly

Ryan²,

MacEneaney³

et al. 2014

Oncol Res Treat

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SummaryBackground: Lhermitte's sign (LS) is characterized by electric shock-like sensations, spreading along the spine in a cervico-caudal direction and into the arms and legs. It is felt upon flexion of the neck and reflects a myelopathy resulting from damage to sensory axons at the dorsal columns of the cervical spinal cord. In patients with cancer, LS can occur due to direct tumour involvement of the spine or in relation to radiotherapy. Chemotherapy-related LS has only rarely been reported. Case Report: We present the case of a 44-year-old patient treated with platinum- and etoposide-based chemotherapy for metastatic seminoma, who subsequently developed severe disabling LS. The severity and duration of LS in this case exceeds prior reports. We review the literature on chemotherapy-related LS and discuss the practice implications. Conclusion: Neuropathy and LS related to cisplatin-based chemotherapy can result in significant adverse effects. Raised awareness of this complication could aid sub-phenotyping of the population most at risk and assist strategies to avert discomfort and disability post chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…It has also been referred to as barber chair sign [1]. LS was first described in 1917 related to cranial trauma and subsequently characterised by Jean Lhermitte in 1920 [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…However, LS as a complication of chemotherapy, as in our case, has been rarely reported. Most cases occur in association with cisplatin or oxaliplatin [1,3]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lhermitte's Phenomenon and Platinum, Beware of Latency

O’Reilly

Ryan²,

MacEneaney³

et al. 2014

Oncol Res Treat

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“…Boyun ağrısı ve sertlik, hissizlik ve ellerde yanma, güçsüzlük, bilateral kollarda parestezi, yürüme bozuklukları ve/veya L'Hermitte's fenomeni bulguları geliştiği zaman, hastaların medikal müdahaleye ihtiyaçları olabilir. [8] Otonomik semptomlar; başlangıçta olmayan, diğer semptomlara eşlik eden idrar sıklığında artış, idrar kaçırma ve üriner inkontinansı içerir. [9] Bazı çalışmalarda, belirgin yürüme bozukluğu, servikal spondilotik miyelopati (SSM)'nin en sık klinik prezantasyonu olarak bildirilmiştir ve spastik yürüyüş ilk belirti iken, bunu üst ekstremite güçsüzlüğü ve ellerde ince motor kontrol kaybı izler.…”

Section: Servi̇kal Spondi̇loti̇k Mi̇yelopati̇ (Ssm)unclassified

Servikal dejeneratif disk hastalığı: genel bakış ve epidemiyoloji

Oltulu¹,

Saka²

2017

TOTBID

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İntervertebral disk vertebral gövdeler arasında artikülasyondan sorumlu olmakla birlikte, silindirik ve fibrokartilajenöz yapıdadır. Fleksiyon, ekstansiyon ve rotasyona izin vermektedir. Makroskobik olarak anulus fibrozis denilen bir dış tabaka ve santralde lokalize nükleus pulpozus denilen bir iç tabakadan oluşmaktadır. [2] İntervertebral disk, kraniyal ve kaudalde kemik ve hiyalin kartilajdan oluşan endplate ile çevrilidir. [2] Bunların en temel majör görevlerinden birisi, yüksek oranda hidrate nükleus pulpozusun komşu vertebraya fıtıklaşmasını önlemektir. [2] Yaşlanmayla birlikte, intervertebral diskin ekstrasellüler matriks kompozisyonunda, hücre içeriğinde değişiklikler olur. [3] Ancak, bu değişiklikler sadece lumbar omurgada gösterilmiştir. S ervikal spondiloz, intervertebral disklerin dejenerasyonu sonucu servikal omurgada oluşan yaşlanmadır. [1] Bu süreçte, servikal omurgada disk mesafesinde kısalma, bağlarda kalınlaşma, ligamentöz ve segmenter instabilite gelişmesi, faset eklemlerde artroz ve lordoz kaybı görülür. [1] Dejeneratif disk değişiklikleri, sıklıkla taşma (bulging), protrüzyon, ekstrüzyon, sekestrasyon şeklinde görülmektedir. Servikal diskler, anteriorda posteriora göre daha kalındır ve bu durum normal lordozun oluşmasını sağlar. Dejeneratif süreçte, öncelikle diskin anteriorunda yükseklik azalmakta ve lordoz kaybı oluşmaktadır. Yaşlanmayla birlikte süreç ilerler ve dejeneratif değişikliklere bağlı aksiyel boyun ağrısı ve/veya disk hernilerine, intraspinal kanal ve foraminal darlıklara, sekonder radikülopati veya miyelopati semptomlarına yol açar.

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Head and neck cancer survivorship consensus statement from the American Head and Neck Society

Goyal

Day

Epstein

et al. 2021

Laryngoscope Investig Oto

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Objectives: To provide a consensus statement describing best practices and evidence regarding head and neck cancer survivorship.Methods: Key topics regarding head and neck cancer survivorship were identified by the multidisciplinary membership of the American Head and Neck Society Survivorship, Supportive Care & Rehabilitation Service. Guidelines were generated by combining expert opinion and a review of the literature and categorized by level of evidence.Results: Several areas regarding survivorship including dysphonia, dysphagia, fatigue, chronic pain, intimacy, the ability to return to work, financial toxicity, lymphedema, psycho-oncology, physical activity, and substance abuse were identified and discussed. Additionally, the group identified and described the role of key clinicians in survivorship including surgical, medical and radiation oncologists; dentists; primary care physicians; psychotherapists; as well as physical, occupational, speech, and respiratory therapists. Conclusion:Head and neck cancer survivorship is complex and requires a multidisciplinary approach centered around patients and their caregivers. As survival related to head and neck cancer treatment improves, addressing post-treatment concerns appropriately is critically important to our patient's quality of life. There continues to be a need to define effective and efficient programs that can coordinate this multidisciplinary effort toward survivorship.

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Lhermitte's sign: Review with special emphasis in oncology practice

Cited by 23 publications

References 66 publications

Lhermitte's Phenomenon and Platinum, Beware of Latency

Lhermitte's Phenomenon and Platinum, Beware of Latency

Servikal dejeneratif disk hastalığı: genel bakış ve epidemiyoloji

Head and neck cancer survivorship consensus statement from the American Head and Neck Society

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