2010
DOI: 10.1186/cc8999
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Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care

Abstract: Critically ill patients are frequently prescribed sedatives and analgesics to ensure patient safety, to relieve pain and anxiety, to reduce stress and oxygen consumption, and to prevent patient ventilator dysynchrony. Recent studies have revealed that these medications themselves contribute to worsening clinical outcomes. An evidence-based organizational approach referred to as the ABCDE bundle (Awakening and Breathing Coordination of daily sedation and ventilator removal trials; Choice of sedative or analgesi… Show more

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Cited by 172 publications
(95 citation statements)
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“…13,[31][32] Because these medications themselves contribute to worsening clinical outcomes, an evidence-based organizational approach referred to as the ABCDE bundle (Awakening and Breathing Coordination, Delirium monitoring and management, and Early mobility and exercise) has recently been suggested. 72,73 The goal of this approach is to liberate critically ill adults from the harmful effects of exposure to sedatives by using targetbased sedation protocols, spontaneous awakening trials, and proper choice of sedatives. 73 An additional goal is early mobilization, 73 which will hopefully reduce delirium and improve neurocognitive outcomes.…”
Section: Pharmacological Methodsmentioning
confidence: 99%
“…13,[31][32] Because these medications themselves contribute to worsening clinical outcomes, an evidence-based organizational approach referred to as the ABCDE bundle (Awakening and Breathing Coordination, Delirium monitoring and management, and Early mobility and exercise) has recently been suggested. 72,73 The goal of this approach is to liberate critically ill adults from the harmful effects of exposure to sedatives by using targetbased sedation protocols, spontaneous awakening trials, and proper choice of sedatives. 73 An additional goal is early mobilization, 73 which will hopefully reduce delirium and improve neurocognitive outcomes.…”
Section: Pharmacological Methodsmentioning
confidence: 99%
“…[25,[27][28][29] This comprises of: Awakening (using light or minimal sedation); Breathing (spontaneous breathing trials); Coordination of care and communication among various disciplines; Delirium monitoring, assessment, and management; Early ambulation in the ICU.…”
Section: Prevention and Management (The Abcde Bundle)mentioning
confidence: 99%
“…The finding that hospital volume is also associated with report of higher level ICU activity in Washington hospitals likely results in part from larger hospitals implementing higher quality sedation order sets, as mobility use is often linked to levels of sedation (16,19,30). Care bundles that have linked sedation and mobility, such as the "ABCDE" bundle proposed by Ely and colleagues, may result in greater adoption of mobility as an intervention (31)(32)(33).…”
Section: Original Researchmentioning
confidence: 99%