Liberation of histamine from the skeletal muscle by curare

Alam, Mohammed Rabiul; Anrep, G. V.; Barsoum, G. S.; Talaat, Mohamed; Wieninger, E

doi:10.1113/jphysiol.1939.sp003716

Cited by 110 publications

(24 citation statements)

References 6 publications

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“…been proven by numerous authors, since its first observation by Alam et al (1939) in the skeletal muscle of dogs (for reviews see Paton, 1956Paton, , 1957Paton, , 1959Murphy, 1962;Rotschild, 1966;Lorenz and Werle, 1971). Sometimes direct methods have been used, when histamine itself was measured in body fluids or in tissues.…”

Section: Introductionmentioning

confidence: 96%

An improved method for the determination of histamine release in man: Its application in studies with propanidid and thiopentone

Lorenz

Doenicke

Meyer

et al. 1972

European Journal of Pharmacology

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improved method for the determination of histamine release in man: its application in studies with propanidid and thiopentone, European J. Pharmacol. 19 (1972) 180-190. tlistamine release by propanidid and thiopentone was demonstrated with the use of a highly sensitive and specific method for determining histamine in human plasma. 5 min after i.v. administration of propanidid and 3 rain after thiopentone, the plasma histamine level was increased by 350 and 4205~ respectively. In whole blood, histamine release could be demonstrated only when the basophil content remained constant. This was the case in about 50% of test persons after injection of propanidid, but not after administration of thiopentone where the basophil content decreased in all probands by about 35%. The increase of the histamine concentration in plasma was 3 ng/ml and in whole blood, 24 ng/ml, ttalfmaximum gastric acid secretion was elicited by injection of propanidid and thiopentone. It was increased by very rapid application of propanidid and diminished by premedication with atropine by about 30%. The changes in plasma histamine and gastric secretion were parallel over 30 rain, whereas tachycardia and peripheral arterial hypotension lasted for only 3 4 min.During i.v. infusion of histamine a correlation could be shown between the doses infused, (15-90 ng/kg)/min, and the elevation of the plasma histamine concentration. 3 ng/ml plasma were measured at a dose of 145 ng/kg)/min, which induced a half-maximmn gaslric secretion, but was without effect on blood pressure and heart rate. It is concluded that only the increase of plasma histamine concentration, not that of whole blood, represented the release of free, pharmacologically active histamine. In normal test persons, histamine release by propanidid and thiopentone is without significant clinical consequences, but it is important in anaphylactoid incidents occurring during anesthesia with these substances.

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Section: Introductionmentioning

confidence: 96%

An improved method for the determination of histamine release in man: Its application in studies with propanidid and thiopentone

Lorenz

Doenicke

Meyer

et al. 1972

European Journal of Pharmacology

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“…Since the portal pressure still responds to histamine after it has become insensitive to tuboeurarine, the loss of sensitivity cannot be due, as Alam et al (1939) suggest, to the antihistamine action of liberated histamine. The experiments with the lungs indicate that there is decreased ability to liberate histamine.…”

Section: Discussionmentioning

confidence: 99%

“…Sinee ganglia are absent from the region of distribution of the drug, and in any case the nerves to the muscles had been cut, the vasodilatation is not due to au effect on ganglia. In view of tlie observations of Sehild and Gregory (1047) and Alam et at (1939) it is attributable to the release of histamine.…”

Section: The Effect Of Tuboeurarine On the Blood Vessels Of The Uiml mentioning

confidence: 99%

The Liberation of Histamine and Heparin by Tubocurarine and Its Circulatory Effects in the Dog

Reid

1950

Aust J Exp Biol Med

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“…USE OF A DRUG ANTAGONIST FOR THE IDENTIFICATION OF AN UNKNOWN SUBSTANCE Curare causes the release of a histamine-like substance from the perfused gastrocnemius muscle of the dog (Alam et al, 1939). In the present experiment a dog's hind limb was perfused with defibrinated blood by means of a DaleSchuster pump, the blood being oxygenated through the animal's own lungs; a solution of 50 mg. crude curare was injected into the artery perfusing the limb and the effluent was collected.…”

Section: Methodsmentioning

confidence: 98%

The Use of Drug Antagonists for the Identification and Classification of Drugs

Schild

1947

British Journal of Pharmacology and Chemotherapy

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A sensitive biological method for the identification of drugs has been described by Chang and Gaddum (1933). It consists in estimating the activity of an unknown substance in terms of a standard, quantitatively, in several different pharmacological tests. As a rule the ratio of activity between standard and unknown in different tests is only constant if the two samples are chemically identical, otherwise the ratio of activity in different tests varies. By this method even closely related substances may be differentiated.Another biological method for the identification and differentiation of drugs consists in testing quantitatively their responses towards antagonists. It has been shown in a previous communication (Schild, 1947) that the effects of histamine and acetylcholine may be thus distinguished, since many antagonists although unspecific at high concentrations will differentiate between these drugs at lower concentrations. The present investigation is concerned with the question whether drugs which are more closely related than histamine and acetylcholine may also be differentiated in this way, or whether antagonists, even though they may be used in an exact and quantitative manner, would fail to discriminate between closely related substances.If indeed some drugs, although distinguishable chemically or by their relative activity in different pharmacological tests, could not be distinguished by their reactions to antagonists, they might conveniently be grouped into a common pharmacological class. It will be shown that drugs can in fact be found which are. related in this way, and that if a certain simple scheme of drug action be accepted a rational classification of active drugs based on their responses to drug antagonists may be attempted. METHODSThe experiments were done on the isolated ileum of the guinea-pig, employing the apparatus for assaying antagonists on isolated tissues which has previously been described (Schild, 1947).

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Liberation of histamine from the skeletal muscle by curare

Cited by 110 publications

References 6 publications

An improved method for the determination of histamine release in man: Its application in studies with propanidid and thiopentone

An improved method for the determination of histamine release in man: Its application in studies with propanidid and thiopentone

The Liberation of Histamine and Heparin by Tubocurarine and Its Circulatory Effects in the Dog

The Use of Drug Antagonists for the Identification and Classification of Drugs

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