LiBr/β-CD/IBX/H₂O-DMSO: A new approach for one-pot biomimetic regioselective ring opening of chalcone epoxides to bromohydrins and conversion to 1,2,3-triketones

IBX-Mediated Organic Transformations in Heterocyclic Chemistry-A Decade Update

“…Nishanth Verma and co-authors employed LiBr/β-CD in the H 2 O–DMSO mixture for highly regioselective ring cleavage of epoxides 12) affording bromohydrins 13) ( Supplementary Figure S6 ). These bromohydrins 13) were later converted successfully into 1, 2, 3-triketones 14) by the IBX-mediated oxidation in DMSO under room temperature conditions ( Verma et al, 2017 ). Authors reported moderate to good yields for these products.…”

Iodoxybenzoic Acid Supported on Multi Walled Carbon Nanotubes as Biomimetic Environmental Friendly Oxidative Systems for the Oxidation of Alcohols to Aldehydes

“…In the last few years, solid-supported ortho-iodoxybenzoic acid (1-hydroxy-1λ5,2-benziodoxol-1,3-dione, IBX) reagents able to convert primary alcohols to corresponding aldehydes, have been prepared by the immobilization of the active iodine species on chemically inert supports including silica [ 12 ], polystyrene beads [ 13 ], and ionic liquids [ 14 ]. These reagents have been reported to be biomimetic [ 15 , 16 ], contemporary solving problems associated with insolubility in common organic solvents and low stability towards moisture of IBX, combining the environmental advantages of simple recyclability of the reagent, simple purification procedures, easier reaction optimization, and safety related issues [ 13 , 17 ]. For these reasons, IBX supported reagents have been recognized as environmental friendly reagents [ 18 , 19 ].…”

One Pot and Two Pot Synthetic Strategies and Biological Applications of Epoxy-Chalcones

“…Compound 15 was used in the total synthesis of natural products such as stemofuran (17) and eupomatenoid intermediate (18). While, compound 16 was reported for the formation of taxol side chain (19)[84]. Amine derived ligands co-catalyst epoxidation Cyclo(Leu-Leu) and oligopeptides catalysts…”