Licensed to Kill: Mitochondria, Chloroplasts, and Cell Death

Aken, Olivier Van; Breusegem, Frank Van

doi:10.1016/j.tplants.2015.08.002

Cited by 159 publications

(122 citation statements)

References 119 publications

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“…Mitochondria have also been proposed to be linked with PCD via increased ROS production during pathogen defense, such as during the HR (Lam et al, 2001;Mur et al, 2008;Van Aken and Van Breusegem, 2015). In agreement, a wide variety of mutants in mitochondrial functions have been reported to have altered PCD or pathogen defense phenotypes.…”

Section: Mtros In Programmed Cell Death and Pathogen Responsementioning

confidence: 86%

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The Roles of Mitochondrial Reactive Oxygen Species in Cellular Signaling and Stress Response in Plants

et al. 2016

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Section: Mtros In Programmed Cell Death and Pathogen Responsementioning

confidence: 86%

“…mtROS production in plants has been implicated in the execution of programmed cell death (PCD; Van Aken and Van Breusegem, 2015). Great efforts have been made to validate relatively well-described yeast or animal PCD pathways in plants; yet with limited success.…”

Section: Mtros In Programmed Cell Death and Pathogen Responsementioning

confidence: 99%

The Roles of Mitochondrial Reactive Oxygen Species in Cellular Signaling and Stress Response in Plants

et al. 2016

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“…ABI4 in the retrograde response of the chloroplast has recently been shown to be activated through phosphorylation by a MAP kinase cascade in a Ca 2+ -dependent manner, suggesting potential molecular entry points of signal integration (Guo et al, 2016). ANAC017 appears also crucial for the transcriptional response to methyl viologen (MV; paraquat) that produces large amounts of superoxide using electrons from PSI under illuminated conditions and eventually leads to cell death (Van Aken and Van Breusegem, 2015;Van Aken et al, 2016a). Importantly, several MRR target genes (including AOX1a) are not induced by MV.…”

Section: Proteins Regulating Nuclear Transcription In Mitochondrial Smentioning

confidence: 99%

Mitochondrial Energy Signaling and Its Role in the Low-Oxygen Stress Response of Plants

et al. 2018

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ORCID IDs: 0000-0001-5369-7911 (S.W.); 0000-0003-4024-968X (O.V.A.); 0000-0003-0796-8308 (M.S.).Cells of complex organisms typically rely on mitochondria for energy provision. The amount of energy required to sustain cellular activity can vary strongly depending on external conditions. Vice versa, constraints on respiratory activity due to metabolic status or stress insult require mitochondrial signaling to coordinate cellular physiology with the function of the organelle. In this update, we review recent insights into plant mitochondrial energy signaling in the light of their significance to stress acclimation. First, we focus on the characteristic adjustments of the nuclear transcriptome that occur after pharmacological inhibition of the mitochondrial electron transport chain as the output of mitochondrial retrograde signaling. Second, we discuss the proteins that have recently been identified as regulators of the transcript responses and the emerging picture of their action as a signaling network. We then pose the question of how well our current models of inducing mitochondrial dysfunction relate to conditions that plants face naturally. We reason that low-oxygen stress shows striking similarities with electron transport inhibitors with respect to their impact on mitochondrial energy physiology upstream, as well as the cellular transcriptomic response. Finally, we highlight and discuss changes in mitochondrial physiology that are common to both stimuli as candidates for upstream signals. The aim of this update is to better define the physiological context in which mitochondrial signaling operates to provide new directions for future research. RESPONSES TO MITOCHONDRIAL ENERGY SIGNALING AT THE TRANSCRIPT LEVEL

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“…Finally, functional chloroplasts have also been shown to be required for PCD in cell suspensions (Gutierrez et al, 2014) and in a number of LMMs (Mateo et al, 2004;Meng et al, 2009;Bruggeman et al, 2015b). Thus, chloroplasts are now recognized as important components of plant defense response against pathogens (Stael et al, 2015) and are proposed to function with mitochondria in the execution of PCD (Van Aken and Van Breusegem, 2015). However, the exact signaling and metabolic contribution of chloroplasts to PCD remain to be elucidated.…”

mentioning

confidence: 99%

“…However, the exact signaling and metabolic contribution of chloroplasts to PCD remain to be elucidated. Furthermore, cross talk between chloroplasts and mitochondria does occur, such as during photorespiration (Sunil et al, 2013), but whether such communication functions sequentially or in parallel in the control of PCD remains to be determined (Van Aken and Van Breusegem, 2015).…”

mentioning

confidence: 99%

Chloroplast Activity and 3′phosphadenosine 5′phosphate Signaling Regulate Programmed Cell Death in Arabidopsis

Bruggeman

Mazubert²,

Piron‐Prunier³

et al. 2016

Plant Physiol.

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Programmed cell death (PCD) is a crucial process both for plant development and responses to biotic and abiotic stress. There is accumulating evidence that chloroplasts may play a central role during plant PCD as for mitochondria in animal cells, but it is still unclear whether they participate in PCD onset, execution, or both. To tackle this question, we have analyzed the contribution of chloroplast function to the cell death phenotype of the myoinositol phosphate synthase1 (mips1) mutant that forms spontaneous lesions in a light-dependent manner. We show that photosynthetically active chloroplasts are required for PCD to occur in mips1, but this process is independent of the redox state of the chloroplast. Systematic genetic analyses with retrograde signaling mutants reveal that 39-phosphoadenosine 59-phosphate, a chloroplast retrograde signal that modulates nuclear gene expression in response to stress, can inhibit cell death and compromises plant innate immunity via inhibition of the RNA-processing 59-39 exoribonucleases. Our results provide evidence for the role of chloroplast-derived signal and RNA metabolism in the control of cell death and biotic stress response.

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Licensed to Kill: Mitochondria, Chloroplasts, and Cell Death

Cited by 159 publications

References 119 publications

The Roles of Mitochondrial Reactive Oxygen Species in Cellular Signaling and Stress Response in Plants

The Roles of Mitochondrial Reactive Oxygen Species in Cellular Signaling and Stress Response in Plants

Mitochondrial Energy Signaling and Its Role in the Low-Oxygen Stress Response of Plants

Chloroplast Activity and 3′phosphadenosine 5′phosphate Signaling Regulate Programmed Cell Death in Arabidopsis

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