Lichen Metabolites: An Overview of Some Secondary Metabolites and Their Biological Potential

Goga, Michal; Elečko, Ján; Marcinčinová, Margaréta; Ručová, Dajana; Bačkorová, Miriam; Bačkor, Martin

doi:10.1007/978-3-319-96397-6_57

Cited by 72 publications

(70 citation statements)

References 82 publications

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“…So far more than 1000 acidic metabolites are known from lichens [20,21]. In spite of the anticancer and antiproliferative activity of some of these compounds [2] the low concentrations within a tiny thallus (5-10% of dry weight) together with laborious isolation prevent pharmaceutic use [22].…”

Section: Discussionmentioning

confidence: 99%

“…Lichens represent chemically important symbiotic organisms of fungi (mycobiont) and algae/ cyanobacteria (photobiont) which produce a various secondary metabolites. Approximately 1000 secondary metabolites were discovered so far and they are specific for lichens [1,2]. Secondary metabolites are classified by their biosynthetic origins and chemical structures.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress mediated by gyrophoric acid from the lichen Umbilicaria hirsuta affected apoptosis and stress/survival pathways in HeLa cells

Goga

Kello

Vilková

et al. 2019

BMC Complement Altern Med

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Background: Lichens produce a huge diversity of bioactive compounds with several biological effects. Gyrophoric acid (GA) is found in high concentrations in the common lichen Umbilicaria hirsuta, however evidence for biological activity was limited to anti-proliferative activity described on several cancer cell lines. Methods: We developed and validated a new protocol for GA isolation, resulting in a high yield of highly pure GA (validated by HPLC and NMR) in an easy and time saving manner. Anti-proliferative and pro-apoptotic activity, oxygen radicals formation and stress/survival proteins activity changes was study by flow cytometry. Results: The highly purified GA showed anti-proliferative activity against HeLa (human cervix carcinoma) and other tumor cells. Moreover, GA threated cells showed a significant increase in caspase-3 activation followed by PARP cleavage, PS externalization and cell cycle changes mediated by oxidative stress. Production of oxygen radicals led to DNA damage and changes in stress/survival pathways activation. Conclusions: GA treatment on HeLa cells clearly indicates ROS production and apoptosis as form of occurred cell death. Moreover, DNA damage and changing activity of stress/survival proteins as p38MAPK, Erk1/2 and Akt mediated by GA treatment confirm pro-apoptotic potential. The pharmacological potential of U. hirsuta derived GA is discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidative stress mediated by gyrophoric acid from the lichen Umbilicaria hirsuta affected apoptosis and stress/survival pathways in HeLa cells

Goga

Kello

Vilková

et al. 2019

BMC Complement Altern Med

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“…insignificantly in three extracts of Cladonia fimbriata, which conflicts with other studies. Environmental factors including temperature, seasonality, UV-exposure, elevation as well as age of lichens influence secondary metabolites [38]. Therefore, it is safe to assume that the contradicting results could be caused by various other factors such as the type of cancer cell line.…”

Section: Plos Onementioning

confidence: 99%

Differential anti-proliferative and apoptotic effects of lichen species on human prostate carcinoma cells

et al. 2020

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“…Lichens are natural reservoirs of novel compounds, with over 800 lichen compounds described to date ( 1 ) and many being used in industry ( 2 ). As such, they represent fertile opportunities for bioprospecting.…”

Section: Announcementmentioning

confidence: 99%

Complete Genome Sequence of an Australian Strain of the Lichen-Forming Fungus Endocarpon pusillum (Hedwig)

Mead

Gueidan

2020

Microbiol Resour Announc

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Lichen Metabolites: An Overview of Some Secondary Metabolites and Their Biological Potential

Cited by 72 publications

References 82 publications

Oxidative stress mediated by gyrophoric acid from the lichen Umbilicaria hirsuta affected apoptosis and stress/survival pathways in HeLa cells

Oxidative stress mediated by gyrophoric acid from the lichen Umbilicaria hirsuta affected apoptosis and stress/survival pathways in HeLa cells

Differential anti-proliferative and apoptotic effects of lichen species on human prostate carcinoma cells

Complete Genome Sequence of an Australian Strain of the Lichen-Forming Fungus Endocarpon pusillum (Hedwig)

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