Lichen planus and chronic active hepatitis

Rebora, Alfredo; Rongioletti, Franco

doi:10.1016/s0190-9622(84)80140-1

Cited by 52 publications

(34 citation statements)

References 2 publications

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“…Current concepts on the pathogenesis of this disease include genetic predisposition and immunological involvement (28). A n increased prevalence (up to 35%) of chronic liver disease of unknown pathogenesis has been reported in patients with lichen planus (29,30;Rebora A,et Correspondence). We recently demonstrated by PCR that the cause of CAH in six patients with lichen planus was HCV (31).…”

Section: Hepatology April 1994mentioning

confidence: 99%

Immunological disorders in C virus chronic active hepatitis: A prospective case-control study

Pawlotsky¹,

Yahia²,

et al. 1994

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Hepatitis C virus-related chronic hepatitis may be associated with various immunological disorders. The aim of this study was to determine prospectively the prevalence of the clinical, biochemical and pathological immunological abnormalities in a series of 61 consecutive patients with chronic hepatitis C, compared with those in 61 age- and sex-matched control subjects without markers of hepatitis C virus and hepatitis B virus infections and with those in 61 patients with chronic hepatitis B. The following investigations were systematically performed before any treatment: detection of serum cryoglobulinemia and rheumatoid factor, detection of a large variety of serum anti-tissue antibodies, biopsy of labial salivary glands, ophthalmological examination, dosage of thyroid-stimulating hormone and in vivo capillary microscopy. Cryoglobulinemia was found in 36% of the hepatitis C virus patients, four of whom had dermatological and/or neurological manifestations of vasculitis, and rheumatoid factor was present in 70%. Serum anti-tissue antibodies were detected in 41% of cases, mostly antinuclear and anti-smooth muscle antibodies. Liver-kidney microsomal and antithyroid antibodies were rare. Salivary gland lesions were found in 49% of the patients: all had lymphocytic capillaritis, sometimes associated with lymphocytic sialadenitis resembling that of Sjögren's syndrome, but without features of sicca syndrome and Ro/SSA antibodies. Five percent of the patients had lichen planus. The prevalences of cryoglobulinemia, rheumatoid factor and anti-tissue antibodies were significantly higher than those in the control group and patients with chronic hepatitis B.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Hepatology April 1994mentioning

confidence: 99%

Immunological disorders in C virus chronic active hepatitis: A prospective case-control study

Pawlotsky¹,

Yahia²,

et al. 1994

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“…An association between lichen planus (LP) and chronic active hepatitis (CAH) was first reported by Rebora et al (1978). Later studies found an increased prevalence of CAH in patients with LP ranging from 4.0 to 13.5% (Rebora et al , 1982; Korkij et al , 1984; Rebora and Rongioletti, 1984; Ayala et al , 1986; Cottoni et al , 1988; del Olmo et al , 1989; Gandolfo et al , 1992). In addition, in two studies of LP patients from Italy and Spain an increased frequency of hepatic cirrhosis was noted [del Olmo et al , 1989; Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED), 1990].…”

Section: Introductionmentioning

confidence: 98%

Lack of evidence of hepatic disease in patients with oral lichen planus in Serbia

Bokor-Bratic

2004

Oral Diseases

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“…This is in accordance with the study of Lodi G et al [12] where the observed histological evidence was 60%. In contrast, a lower incidence was reported by Rebora A [13] 11.3% and Sanchez Perez et al [11] 23%.…”

Section: Discussionmentioning

confidence: 80%