2009
DOI: 10.1016/j.jaad.2008.09.032
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Lichen planus–like eruptions: An emerging side effect of tumor necrosis factor-α antagonists

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Cited by 172 publications
(117 citation statements)
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References 33 publications
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“…No clear event precipitating TNF-a blockers cutaneous eruptions has yet been identified (2,4,(19)(20)(21)(22); on the contrary, the triggers of our cases were seemingly manifest (topical imiquimodin the presence of a population of neoplastic KCs, both factors conjunctively prompting release of IFN-a), with the reactions always being limited to areas of application and sparing any distant sites.…”
Section: Discussioncontrasting
confidence: 61%
See 1 more Smart Citation
“…No clear event precipitating TNF-a blockers cutaneous eruptions has yet been identified (2,4,(19)(20)(21)(22); on the contrary, the triggers of our cases were seemingly manifest (topical imiquimodin the presence of a population of neoplastic KCs, both factors conjunctively prompting release of IFN-a), with the reactions always being limited to areas of application and sparing any distant sites.…”
Section: Discussioncontrasting
confidence: 61%
“…To date, it has not been understood why only a minority of patients developed any of these anti-TNF-a-induced reactions in general, and any specific clinico-pathological variants in particular. It seems likely that the common setting of systemic TNF-a inhibition always plays a key role, whereas currently unresolved differences in signaling cascades would account for small rates of affected patients as well as observed variances in clinicopathological outcomes (4,21,23).…”
Section: Discussionmentioning
confidence: 99%
“…Bunlar içerisinde etanersept ile oluşan kutanöz yan etkiler; enjeksiyon yeri reaksiyonları, ekzematöz deri lezyonları, lupus eritematozus, eritema multiforme, deri enfeksiyonları, vasküler lezyonlar, deri kanserleri ve likenoid erüpsiyonlar olarak sayılabi-lir. [2][3][4][5] Likenoid erüpsiyonlar, aslında çok sayıda ilaca bağlı olarak görülebilmektedir. Özellikle altın tuzları, β blokerler, antimalaryaller, tiyazid diüretik-ler, furosemid, spirinolakton ve penisilamin en sık neden olan ilaçların başında gelmektedir.…”
Section: Olgu Sunumuunclassified
“…[1][2][3][4][5] TNF-α inhibitörleri ile tedaviye başlanması ve likenoid erüpsiyonların görülmesi arasındaki süre, genellikle üç hafta ile 16 ay arasında değişmekle birlikte, en sık tedaviye başlandıktan sonraki ilk iki ayda izlenmektedir. 3 Hastaların çoğunluğunda tedavinin kesilmesini gerektirmeden erüpsiyon iyileş-miştir. 2 Bizim hastamızda da etanersept ile tedaviye başlandıktan dört ay sonra gövde yan ve arka yüzde likenoid erüpsiyon izlenmiş ve etanersept kullanımı kesilmeden topikal tedavi ile iyileşme sağlanmıştır.…”
Section: Olgu Sunumuunclassified
“…Lichen Planopilaris: Lichenoid drug reactions are a wellestablished adverse reaction to TNF-α inhibitors [48]. A rare but reported subcategory includes TNF-α inhibitor induced lichen planopilaris (LPP).…”
Section: Clinical Subtypes Of Alopecia Seen During Treatment With Tnfmentioning
confidence: 99%