Cell-mediated immunological mechanisms are believed to be predominant in the pathogenesis of oral lichen planus (OLP;Lu et al., 2015). The current understanding suggests that OLP is a T-cellmediated autoimmune disease where CD8 + T cells trigger apoptosis of oral epithelial cells at the basal layer (Krupaa et al., 2015).Abnormal expression patterns of various inflammation-related cytokines reflect the immune dysregulation in the interactions between keratinocytes, T cells and many other cell types (Lu et al., 2015).With the development of cold physical plasma sources that are operated at body temperature, the application of this technology as a novel treatment modality for different diseases became fea-