Lichen sclerosus

Yesudian, Patrick; Sugunendran, H; Bates, Christine; O'Mahony, C

doi:10.1258/0956462054308440

Cited by 46 publications

(41 citation statements)

References 45 publications

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“…The risk of squamous cell carcinoma (SCC) is estimated to be 4-5% in vulva LS. 3 There was no case of malignancy detected in this study but long term follow up is necessary to document these changes.…”

Section: Discussionmentioning

confidence: 64%

“…3 Most common sites are trunk, upper back, sites of pressure,thighs. 2 In this study 10(18.6%) cases of extragenital LSA were detected.…”

Section: Discussionmentioning

confidence: 99%

“…are the associated factors implicated in the pathogenesis of LSA and should also be evaluated. 3,7,8 Treatment options available for LSA are potent topical steroids, topical tacrolimus, topical calcipotriol, oral acetretin and antimalarials. 2 Management is purely dermatological in its early stages but inputs are required from different disciplines as the disease progresses.…”

Section: Discussionmentioning

confidence: 99%

“…2 Aetiology is multifactorial which includes autoimmunity, hormonal factors, infections, local factors, genetic factors. 3 Clinical pattern range from asymptomatic to pruritic sclerotic plaques and end stage balanitis xerotica obliterans in men. The objective of this study was to document the clinical, demographic pattern and associated systemic diseases of lichen sclerosus (LSA) in patients attending Skin OPD, RIMS, Imphal.…”

Section: Introductionmentioning

confidence: 99%

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Lichen sclerosus: a clinical study

et al. 2017

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INTRODUCTIONLichen sclerosus (LS) is a chronic inflammatory disorder predominantly involving the anogenital skin and rarely extra genital site. It is more prevalent in females accounting for a 5:1 gender ratio.1 There is bimodal peak of incidence from prepubertal children to postmenopausal group in women and 30-50 years of age in men.2 Aetiology is multifactorial which includes autoimmunity, hormonal factors, infections, local factors, genetic factors. 3Clinical pattern range from asymptomatic to pruritic sclerotic plaques and end stage balanitis xerotica obliterans in men. The objective of this study was to document the clinical, demographic pattern and associated systemic diseases of lichen sclerosus (LSA) in patients attending Skin OPD, RIMS, Imphal. METHODS Inclusion criteriaInclusion criteria was all patients presenting with signs and symptoms consistent with LSA either clinically or histopathologically. ABSTRACTBackground: Lichen sclerosus (LS) is a chronic inflammatory disorder that preferentially affects the anogenital region and rarely extra genital sites. It is more common in women and has a bimodal peak of incidence. The objective of the study was to document the clinical, demographic pattern and associated systemic diseases of lichen sclerosus (LS) among patients attending skin OPD, RIMS, Imphal. Methods: All patients presenting with signs and symptoms suggestive of lichen sclerosus (LS) were studied for a period of 24 months from March 2014 to February 2016. Clinical examination and relevant investigations including histopathology were performed. Results: A total of 54 patients were studied (17 males and 37 females). M:F ratio was 1:2.2. Majority belonged to 25-44 years age group (29.6%). Ano-genital LS comprised 81.4% of the cases. All patients presented with hypopigmented atrophic plaque (100%). The commonest site was prepuce (53.3%) in males and labia majora, labia minora and clitoris (62%) in females. There were 2 cases of balanitis xerotica obliterans (BXO). Ten patients (18.6%) had extragenital LSA and the sites involved were trunk, waist and extremities. Associated systemic diseases were detected in 6 patients. Conclusions: Lichen sclerosus is not an uncommon disease. Varied presentations ranging from asymptomatic white patch to severe inflammation and scarring were noted. Complications especially with genital involvement can be prevented by early diagnosis and adequate treatment. Screening for associated systemic disease may prove useful.

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Section: Discussionmentioning

confidence: 64%

“…3 Most common sites are trunk, upper back, sites of pressure,thighs. 2 In this study 10(18.6%) cases of extragenital LSA were detected.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lichen sclerosus: a clinical study

et al. 2017

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“…Unterstützt wird diese Hypothese dadurch, dass die höchste Inzidenz eines LS bei Frauen mit physiologisch niedrigem Östrogenspiegel (präpubertäre Mäd-chen und postmenopausale Frauen) gefunden wurde [25]. Jedoch zeigte sich kein Zusammenhang von LS mit einer Schwangerschaft, Hysterektomie, Kontrazeptivaeinnahme oder hormoneller Substitutionstherapie [41].…”

Section: äTiologieunclassified

Lichen sclerosus in the genitourinary region

Hofer¹,

Köhn²,

Hatzichristodoulou

et al. 2011

Urologe

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Lichen sclerosus (LS) is a chronic inflammatory disorder of the skin and mucosa, presenting to genitourinary physicians, pediatricians, and dermatologists. It affects both sexes with a lower incidence in men than in women. Autoimmune factors, infections, and genetic disposition are implicated in its pathogenesis. The classic clinical picture is of atrophic white plaques in the anogenital region. Pruritus, soreness, difficulty retracting the foreskin, and obstructive urinary symptoms are frequent complaints. Early histological confirmation by biopsy is recommended. The disorder is usually highly responsive to ultrapotent topical steroids. This may help arrest or delay the progressive nature of this disorder. Surgical treatment may be needed in cases of disease progression despite medical therapy. Circumcision is a successful treatment, if LS is limited to the glans and foreskin. In cases of meatal stenosis meatoplasty and in cases of urethral involvement one- or two-stage oral graft urethroplasty is necessary.

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