Lichen Sclerosus Et Atrophicus in Childhood

Ditxowsky, Sol P.; Falk, Alfred B.; Baker, Norman; Schaffner, Morton

doi:10.1001/archpedi.1956.02060020054012

Cited by 13 publications

(8 citation statements)

References 4 publications

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“…We advocate ongoing topical therapy with a moderate-potency corticosteroid after remission is first achieved, with a reevaluation at 3 months followed by review every 6 months and then annually once the disease has been stable for 2 years. Early reports of childhood VLS proposed that it would remit completely at puberty (17)(18)(19). Ridley (20) first challenged this several decades ago.…”

Section: Discussionmentioning

confidence: 99%

Prepubertal‐Onset Vulvar Lichen Sclerosus: The Importance of Maintenance Therapy in Long‐Term Outcomes

Ellis

Fischer

2015

Pediatric Dermatology

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Section: Discussionmentioning

confidence: 99%

Prepubertal‐Onset Vulvar Lichen Sclerosus: The Importance of Maintenance Therapy in Long‐Term Outcomes

Ellis

Fischer

2015

Pediatric Dermatology

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“…Non-genital lichen sclerosus occurs in response to a variety of types of tissue damage: scarring; solar and therapeutic irradiation; pressure under areas of tight clothing, for example, brassiere straps and belts; where body parts rub, for example, pendulous breasts against the chest wall and in acrochorda (59)(60)(61)(62)(63)(64)(65)(66)(67) . Genital lichen sclerosus is associated with many conditions that give rise to local itch, for example, vulvovaginal candidiasis and trichomoniliasis in women and nonspecific vulvovaginitis in girls, pinworm, urinary tract infection, diabetes, and obesity (39,65,67,68) .…”

Section: Lichen Sclerosus As a Kö Bner Phenomenonmentioning

confidence: 99%

Does lichen sclerosus play a central role in the pathogenesis of human papillomavirus negative vulvar squamous cell carcinoma? The itch-scratch-lichen sclerosus hypothesis

Scurry¹

1999

Int J Gynecol Cancer

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In the past decade, two types of vulvar squamous cell carcinoma (SCC) have been delineated, Human papillomavirus (HPV) positive and negative. Clinicopathologic, virologic, cytomorphometric, and genetic differences support the view that these two types of carcinoma are fundamentally different and that HPV‐negative carcinoma is not simply carcinoma where viral DNA has not been able to be identified. The traditional view of HPV‐negative carcinoma is that it is caused by chronic tissue damage from itching and scratching. However, itching and scratching alone do not explain the close association of carcinoma with lichen sclerosus, nor the absence of such an association with other itchy conditions such as eczema or psoriasis. These observations point to a role for lichen sclerosus in the pathogenesis of vulvar carcinoma. Most observations about the etiology of lichen sclerosus can be grouped into its immunogenetic or genital predisposition, or the Köbner phenomenon. In the itch‐scratch‐lichen sclerosus hypothesis, lichen sclerosus is postulated to occur as a Köbner phenomenon in women with the susceptible immunophenotype who scratch because of genital irritants such as urine, vaginal secretions and smegma, and psychological factors. Lichen sclerosus, itself a very itchy condition, contributes to a vicious cycle of itching and scratching which leads to superimposed lichen simplex chronicus, squamous cell hyperplasia, and ultimately carcinoma. The itch‐scratch‐lichen sclerosus hypothesis reconciles the traditional itch‐scratch hypothesis with the strong clinicopathologic association of lichen sclerosus with carcinoma.

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“…In contrast, Ditkowsky et al. , 17 the first group investigating a comorbidity between LS and atopy in childhood, noted six types of allergic manifestation in eight girls but questioned a relationship. To our knowledge, to date only Lipscombe et al.…”

Section: Discussionmentioning

confidence: 91%

“…Powell and Wojnarowska 8 found 59% of their cohort of 70 girls with LS to have a personal history of atopy. In contrast, Ditkowsky et al, 17 the first group investigating a comorbidity between LS and atopy in childhood, noted six types of allergic manifestation in eight girls but questioned a relationship. To our knowledge, to date only Lipscombe et al 12 have investigated an association between atopy and LS in male patients and found a history of atopy in 34% of patients with LS.…”

Section: Discussionmentioning

confidence: 91%