Lichen sclerosus in female patients is associated with an increased risk of metabolic syndrome and cardiovascular comorbidities: a retrospective cohort review

Ranum, Alison; Freese, Rebecca; Ramesh, Vidhyalakshmi; Pearson, David R.

doi:10.1111/bjd.21811

Cited by 6 publications

(9 citation statements)

References 11 publications

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“…Two recent studies of 585 and 455 women with LS found hypertension and type 2 diabetes more often in LS women than in controls 13,14 . In the present study, the odds of LS were reduced for hypertensive disorders, type 2 diabetes, and the metabolic syndrome, as well as for coronary artery disease and myocardial infarction.…”

Section: Discussionsupporting

confidence: 53%

“…Two recent studies of 585 and 455 women with LS found hypertension and type 2 diabetes more often in LS women than in controls. 13,14 In the present study, the odds of LS were reduced for hypertensive disorders, type 2 diabetes, and the metabolic syndrome, as well as for coronary artery disease and myocardial infarction. Our results may contradict those of Ranum and Hieta 13,14 because of the unclear temporal relationship of lichen and comorbid condition in the 2 previous studies.…”

Section: Discussionsupporting

confidence: 48%

“…11,12 Moreover, recent studies suggest a link between LS and the metabolic syndrome. 13,14 To shed light on the etiology of LS, we identified sociodemographic and health-related factors related to LS using nationwide registry data from Finland.…”

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confidence: 99%

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Risk Factors for Lichen Sclerosus: A Case-Control Study of 43,000 Finnish Women

Halonen,

Heikinheimo,

Hadkhale

et al. 2024

J Low Genit Tract Dis

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Objectives Lichen sclerosus (LS) is an inflammatory skin disease probably arising from an interplay of genetics, local irritation, and autoimmune processes. We identified potential risk factors for the disease using data from nationwide Finnish registries. Methods We identified all women diagnosed with LS within specialized health care during 1998–2016 (n = 10,692) and selected 3 age-matched population control women for each case. We calculated odds ratios (ORs) for possible risk factors using conditional logistic regression. Results Dermatological autoimmune conditions were strongly associated with LS (OR = 15.1, 95% confidence interval [CI] = 13.6–16.7 for morphea; OR = 10.3, 95% CI = 5.02–19.0 for lichen planus; OR = 6.86, 95% CI = 5.65–8.33 for alopecia; OR = 2.20, 95% CI = 1.88–2.56 for vitiligo). A diagnosis of Crohn or celiac disease increased the odds of LS (OR = 1.80, 95% CI = 1.71–1.89; OR = 1.49, 95% CI = 1.28–1.73, respectively) as did urge and stress incontinence (OR = 1.79, 95% CI = 1.71–1.87; OR = 1.28, 95% CI = 1.22–1.35, respectively). The odds of LS were lower in women after a diagnosis of type 1 diabetes (OR = 0.43, 95% CI = 0.41–0.45), coronary artery disease (OR = 0.41, 95% CI = 0.38–0.43), and rheumatoid arthritis (OR = 0.38, 95% CI = 0.36–0.41). Parous women had higher odds of LS (OR = 1.11, 95% CI = 1.04–1.17) than nulliparous ones, but increasing number of births decreased the risk. Lichen sclerosus was not associated with socioeconomic status nor the urbanicity level of the place of residence. Conclusions Certain autoimmune diseases and urinary incontinence were associated with LS.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionsupporting

confidence: 48%

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Risk Factors for Lichen Sclerosus: A Case-Control Study of 43,000 Finnish Women

Halonen,

Heikinheimo,

Hadkhale

et al. 2024

J Low Genit Tract Dis

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“…There were no differences in the body mass index, triglycerides or HDL levels, probably because of the statin prescription. The authors hypothesize that this relation could be due to an increased systemic inflammation and a decreased overall daily activity level ( 120 ).…”

Section: Associationsmentioning

confidence: 99%

Lichen sclerosus: The 2023 update

et al. 2023

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Lichen sclerosus (LS) is an underdiagnosed inflammatory mucocutaneous condition affecting the anogenital areas. Postmenopausal women are predominantly affected and, to a lesser extent, men, prepubertal children, and adolescents. The etiology of LS is still unknown. Hormonal status, frequent trauma and autoimmune diseases are well-known associations for LS, yet infections do not seem to be clear risk factors. LS pathogenesis involves factors such as a genetic predisposition and an immune-mediated Th1-specific IFNγ-induced phenotype. Furthermore, there is a distinct expression of tissue remodeling associated genes as well as microRNAs. Oxidative stress with lipid and DNA peroxidation provides an enabling microenvironment to autoimmunity and carcinogenesis. Circulating IgG autoantibodies against the extracellular matrix protein 1 and hemidesmosome may contribute to the progression of LS or simply represent an epiphenomenon. The typical clinical picture includes chronic whitish atrophic patches along with itching and soreness in the vulvar, perianal and penile regions. In addition to genital scarring, and sexual and urinary dysfunction, LS may also lead to squamous cell carcinoma. Disseminated extragenital LS and oral LS are also reported. The diagnosis is usually clinical; however, a skin biopsy should be performed in case of an unclear clinical picture, treatment failure or suspicion of a neoplasm. The gold-standard therapy is the long-term application of ultrapotent or potent topical corticosteroids and, alternatively, topical calcineurin inhibitors such as pimecrolimus or tacrolimus. Collectively, LS is a common dermatological disease with a so far incompletely understood pathogenesis and only limited treatment options. To foster translational research in LS, we provide here an update on its clinical features, pathogenesis, diagnosis and (emerging) treatment options.

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“…Other diseases from cluster 2 that are considered associated with lymphoma and leukemia in the literature include ataxia telangiectasia [45], Bloom syndrome [46], cartilage-hair hypoplasia [47], and Chediak-Higashi syndrome [48], among others. Moreover, many diseases from cluster 2 could be associated with cardiovascular diseases, according to the literature: congenital heart defects are observed in 50–85% of cases of CHARGE syndromes [49] ; the TARP syndrome is associated with congenital heart defects [50] ; congenital heart disease is a common feature in the 22q11.2 deletion syndrome (DiGeorge syndrome) [51] ; Parry Romberg syndrome is associated with hypertrophic cardiomyopathy and rheumatologic heart disease [52] ; lichen sclerosus is associated with increased risk of cardiovascular comorbidities in female [53] ; Pearson syndrome is often associated with cardiac conduction defects [54] ; the association of inclusion body myositis and cardiac disease is debated [55] ; a case of Melkersson–Rosenthal syndrome affecting cardiac connective tissues was reported in [56].…”

Section: Diffusion Profiles Comparison To Unveil Immune Diseases Simi...mentioning

confidence: 99%

Random Walk with Restart on multilayer networks: from node prioritisation to supervised link prediction and beyond

Baptista,

Brière,

Baudot

2023

Preprint

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Background: Biological networks have proven invaluable ability for representing biological knowledge. Multilayer networks, which gather different types of nodes and edges in multiplex, heterogeneous and bipartite networks, provide a natural way to integrate diverse and multi-scale data sources into a common framework. Recently, we developed MultiXrank, a Random Walk with Restart algorithm able to explore such multilayer networks. MultiXrank outputs scores reflecting the proximity between an initial set of seed node(s) and all the other nodes in the multilayer network. We illustrate here the versatility of bioinformatics tasks that can be performed using MultiXrank. Results: We first show that MultiXrank can be used to prioritise genes and drugs of interest by exploring multilayer networks containing interactions between genes, drugs, and diseases. In a second study, we illustrate how MultiXrank scores can also be used in a supervised strategy to train a binary classifier to predict gene-disease associations. The classifier performance are validated using outdated and novel gene-disease association for training and evaluation, respectively. Finally, we show that MultiXrank scores can be used to compute diffusion profiles and use them as disease signatures. We computed the diffusion profiles of more than 100 immune diseases using a multilayer network that includes cell-type specific genomic information. The clustering of the immune disease diffusion profiles reveals shared shared phenotypic characteristics. Conclusion: Overall, we illustrate here diverse applications of MultiXrank to showcase its versatility. We expect that this can lead to further and broader bioinformatics applications.

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Lichen sclerosus in female patients is associated with an increased risk of metabolic syndrome and cardiovascular comorbidities: a retrospective cohort review

Cited by 6 publications

References 11 publications

Risk Factors for Lichen Sclerosus: A Case-Control Study of 43,000 Finnish Women

Risk Factors for Lichen Sclerosus: A Case-Control Study of 43,000 Finnish Women

Lichen sclerosus: The 2023 update

Random Walk with Restart on multilayer networks: from node prioritisation to supervised link prediction and beyond

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