Lichen Secondary Metabolites

Ranković, Branislav

doi:10.1007/978-3-319-13374-4

Cited by 109 publications

(10 citation statements)

References 232 publications

(349 reference statements)

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“…They are Molecules 2020, 25, 4301 2 of 22 generally soluble in water and can be easily isolated from the lichens by boiling water. The secondary metabolites synthesized by lichens cover many classes of organic compounds [5]. Secondary metabolites commonly known as lichen acids have diverse biological properties such as the antimicrobial, antibacterial, cytotoxic, antioxidant, antiviral, and antifungal activities [1][2][3][4][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

HPLC Fingerprint Analysis with the Antioxidant and Cytotoxic Activities of Selected Lichens Combined with the Chemometric Calculations

Hawrył

Hajnos-Stolarz³

et al. 2020

Molecules

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The aim of this study was to evaluate the ability of multivariate techniques to predict antioxidant and cytotoxic activity of the selected lichens from the chromatographic data. A simple and reproducible HPLC-DAD technique has been used to obtain the chromatographic fingerprint profiles. Reversed phase high performance liquid chromatography (RP-HPLC) linear gradient system with methanol, water and phosphoric acid (V) (pH 2.3) as the mobile phase was used (50 min). Principal Component Analysis (PCA) has been applied to the evaluation of the phytochemical similarity between studied samples, especially between the same species collected in various places of Poland (Cetraria islandica (L.) Ach., CI, Cladina mitis Sandst., CM, Hypogymnia physodes (L.) Nyl., HP). The ability to scavenge free radicals was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods and the total phenolic content was determined by Folin-Ciocalteu (F-C) test. In the case of DPPH % of inhibition was higher for selected species (Pseudevernia furfuracea (L.) Zopf, H. physodes in comparison to the literature data. The FRAP test showed that the H. physodes extract had higher ability to scavenge free radical in comparison to Cladonia furcata (Huds.) Schrader and Evernia prunastri (L.) Ach., whereas P. furfuracea extract showed higher ability than C. islandica. The high content of phenolics in P. furfuracea and H. physodes confirms their high antioxidant activity. The cytotoxic activity of studied extracts was tested by cell culture method using the human HL-60 / MX2 acute CKL-22 (CRL-2257) promyelocytic leukemia tumor cell line. The lowest values of IC50 [µg∙mL−1] were obtained for: H. physodes (HP1)—99.4; C. digitate—122.6; H. physodes (HP)—136.5, C. subulata—142.6; C. mitis—180.2.

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Section: Introductionmentioning

confidence: 99%

HPLC Fingerprint Analysis with the Antioxidant and Cytotoxic Activities of Selected Lichens Combined with the Chemometric Calculations

Hawrył

Hajnos-Stolarz³

et al. 2020

Molecules

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“…Thus, Lichens are natural sources for therapeutic compounds by producing secondary metabolites exhibiting biological potentialities like antimicrobial activity (Barnes, 2000;Plaza et al, 2017). Several studies have investigated the biological activities of crude extracts and purified compounds of lichen species, such as antioxidant, antimicrobial, antiviral, cytotoxic, insecticidal and anti-inflammatory properties (Mendili, Bannour, et al, 2021;Mendili, Essghaier, et al, 2021;Ranković, 2015). In this context, the Cladonia genus was previously described as secondary metabolites source (Kosanić et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…They produce various chemical substances known as lichen acids. In addition, other secondary metabolites of lichens, including aliphatic, cycloaliphatic, aromatic and terpene chemicals, have important biological and pharmacological properties (Ranković, 2015). In particular, antimicrobial, antioxidant, anticancer, anti-inflammatory, analgesic and antipyretic potentialities were described for lichens.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, antimicrobial, antioxidant, anticancer, anti-inflammatory, analgesic and antipyretic potentialities were described for lichens. The antimicrobial efficacy of numerous lichen genus has been reported in the literature, such as Cladonia, Evernia, Lobaria, Parmelia, Peltigera, Pertusaria, Physcia Roccella, Usnea and Xanthoria (Ranković, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Screening of antimicrobial potential of methanolic, acetone and quencher extracts from Cladonia rangiformis Hoffm. and Cladonia pocillum Ach.

Essghaier¹,

Mendili²,

Khadhri³

2021

NRFHH

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This study compared the efficacy of two species of lichen located in Tunisia belonging to Cladonia rangiformis and Cladonia pocillum species. The antibacterial and antifungal potentials of methanol, acetone and quencher extracts of C. rangiformis and C. pocillum and the lysozyme activity of both methanol extracts were investigated. The results showed that the examined extracts had antimicrobial properties against gram-positive and gram-negative bacteria and anti-Candida properties and that they also limited the spore germination of Penicillium and Aspergillus. Further results showed that the largest diameter of the inhibition zone was obtained by the methanolic extract of C. pocillum with 31 mm and 27.5 mm against E. cloacae and E. coli, respectively. MIC values of bactericidal and fungicidal activities of both Cladonia extracts ranged from 0.25 mg/mL to 2 mg/mL. C. pocillum possess superior lysozyme activity against Staphylococcus aureus and Enterococcus faecalis. Furthermore, the methanol extract of both Cladonia showed a remarkable destructive effect on the morphology of fungal hyphae.

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“…Depsides, such as Gyrophoric acid, umbilicaric acid, and lecanoric acid, which are the eventual products of esterification of orcinol rings through acetyl polymalonyl pathway are mainly produced by most species of family Umbilicariaceae (Nguyen et al, 2013;Oettl et al, 2014;Ranković, 2015). Many studies have demonstrated the presence of high concentrations of phenolic compounds in different Umbilicaria species (Fernández-Moriano et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Chemotype variations among lichen ecotypes of Umbilicaria aprina as revealed by LC-ESI-MS/MS: a survey of antioxidant phenolics

Norouzi

Azizi

Gholami

et al. 2020

Environ Sci Pollut Res

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In the present study, we characterized the phytochemical profile of six distinct ecotypes of Umbilicaria aprina Nyl. from Iran (include: Kivarestan, Mishan, Takht-e Nader, Tochal, Sabalan, and Sahand ecotypes) in order to ascertain whether the environmental differences can affect the chemical profile of this species. Based on the results of LC-ESI-MS/MS, 9 major chemical substances were identified: Orsellinic acid (1), Lecanoric acid (2), Evernic acid (3), Gyrophoric acid (4), Umbilicaric acid (5), Hiascic acid (6), Stictic acid (7), a member of Hiascic acid complex (8), and an unknown substance (9). The MS/MS fragmentation patterns of each substance were determined and proposed. Broad variability was observed in the chemical profiles of lichen samples according to the presence/absence of these substances. The results corroborate that the influence of ecological locality conditions for example altitude, slope aspect, light intensity, and temperature, on phytochemical variations among ecotypes of a particular lichen species like U. aprina are of great importance.

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Lichen Secondary Metabolites

Cited by 109 publications

References 232 publications

HPLC Fingerprint Analysis with the Antioxidant and Cytotoxic Activities of Selected Lichens Combined with the Chemometric Calculations

HPLC Fingerprint Analysis with the Antioxidant and Cytotoxic Activities of Selected Lichens Combined with the Chemometric Calculations

Screening of antimicrobial potential of methanolic, acetone and quencher extracts from <i>Cladonia rangiformis</i> Hoffm. and <i>Cladonia pocillum</i> Ach.

Chemotype variations among lichen ecotypes of Umbilicaria aprina as revealed by LC-ESI-MS/MS: a survey of antioxidant phenolics

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