Licht- und elektronenmikroskopische Untersuchungen der Nieren bei Hunden mit Pyometra

Vasopressin secretion in response to osmotic stimulation and effects of desmopressin on urinary concentrating capacity in dogs with pyometra

“…Renal lesions in dogs with pyometra are believed to be temporary because PU-PD in most affected dogs improves within a few weeks after surgery. 7,19 However, polyuria may remain after surgery, as was seen in the 2 dogs of our study. Thus, the question remains as to whether polyuria is a direct result of the renal lesions.…”

“…Thus, the question remains as to whether polyuria is a direct result of the renal lesions. 5,16,19 Tubular abnormalities in the kidneys of dogs with pyometra may interfere with the cellular action of activated VP receptors. However, the glomerular and tubular lesions described in dogs with pyometra have typically been based on the results of studies 4,19 in which investigators did not include an age-matched control group.…”

“…5,16,19 Tubular abnormalities in the kidneys of dogs with pyometra may interfere with the cellular action of activated VP receptors. However, the glomerular and tubular lesions described in dogs with pyometra have typically been based on the results of studies 4,19 in which investigators did not include an age-matched control group. In 1 study 5 with agematched control dogs, changes were similar in the kidneys of healthy dogs and dogs with pyometra, suggesting that renal lesions in dogs with pyometra are not directly associated with polyuria.…”

“…Renal tubular abnormalities, including hyaline droplet degeneration, cellular swelling and vacuolization, basement membrane thickening, and accumulation of a lipofuscin-like pigment, have been reported in studies 4,19 of dogs with pyometra. They may all play a role in the development of PU-PD in dogs with pyometra, but studies with control dogs of comparable age are lacking.…”

Renal Function in Dogs With Pyometra

“…The polyuria which is associated with pyometra results from reduction of the renal concentrating ability (Asheim 1963). This reduction appears to depend upon reduced resorption of water in the distal and collecting tubules (Asheim 1964 a). A reduction in the medullary sodium gradient is associated with the dysfunction of the collecting tubules (Asheim 1964 b).…”