Lichtheimia corymbifera subcutaneous infection successfully treated with amphotericin B, early debridement, and vacuum-assisted closure

Blázquez, Daniel; Ruiz–Contreras, Jesús; Fernández-Cooke, Elisa; González-Granado, Ignacio; Delgado, Maria Dolores; Menendez, Maria Teresa; Rodriguez-Gil, Yolanda; Ballen, Aida; Palacio, Amalia del

doi:10.1016/j.jpedsurg.2010.08.011

Cited by 15 publications

(7 citation statements)

References 11 publications

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“…Another particularity of our case was the infectious complication with Lichtheimia corimbyfera , a fungus known to infect immunosuppressed patients. It most commonly affects the central nervous system (CNS), but in some particular situations can also infect traumatized skin [17]. In our case, due to her severe pancytopenia secondary to intensive chemotherapy, and the immobilization with pelvipedios gypsum, the patient developed bedsores underneath the gypsum.…”

Section: Discussionmentioning

confidence: 88%

Acute Lymphoblastic Leukemia with Malignant Hypercalcemia: A Case Report

et al. 2019

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Patient: Female, 6 Final Diagnosis: Acute lymphoblastic leukemia Symptoms: Abdominal pain • bloody diarrhea • malaise • vomiting Medication: — Clinical Procedure: Chemotherapy Specialty: Oncology Objective: Unusual clinical course Background: Malignant hypercalcemia is a rare finding in the pediatric population, even more rare in hematological malignancies, such as leukemia. Case Report: We present a case of a 6-year-old female patient who was diagnosed with acute lymphoblastic leukemia, with secondary hypercalcemia. She started chemotherapy following the IC-BFM ALL2002 protocol with simultaneous calcitonin, diuretics and aggressive hydration for hypercalcemia, and went into complete remission after the induction therapy. After 4 months of chemotherapy, she was diagnosed with relapse associated again with malignant hypercalcemia, and underwent chemotherapy with the relapse protocol. There was no response after the first 2 cycles, so we decided to start her on clofarabine. Due to the severe hypercalcemia and consecutive osteolysis, she developed several bone fractures and needed gypsum immobilization. We started her again on calcitonin, but she developed severe adverse reactions, so we found it necessary to start bisphosphonates, first zoledronic acid intravenously, and afterwards clodronate orally. Consolidation of bone fractures was achieved, but due to prolonged immobilization she developed bedsores, superinfected with Lichtheimia corymbifera . We started posaconazole orally, but she rapidly went into severe sepsis with multiple organ failure. The leukemia showed no response to chemotherapy, progressed rapidly, and the patient died. Conclusions: Malignant hypercalcemia is associated with a poor prognosis in leukemia, and might need a more aggressive therapy.

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Section: Discussionmentioning

confidence: 88%

Acute Lymphoblastic Leukemia with Malignant Hypercalcemia: A Case Report

et al. 2019

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“…These cases are generally associated with previous wounds or fractures due to traumatic accidents or surgery. Thus, contamination of wounds, either with plant material during accidents, or via non‐sterile bandages or surgical dressings, is the most likely route of infection . However, nosocomial infections due to person‐to‐person transmission also appear possible .…”

Section: Human Disease Caused By Lichtheimiamentioning

confidence: 99%

“…Thus, contamination of wounds, either with plant material during accidents, or via non-sterile bandages or surgical dressings, is the most likely route of infection. [37][38][39][40][41][42][43] However, nosocomial infections due to person-to-person transmission also appear possible. 44 Interestingly, trauma-related infections have been described in patients without obvious underlying immunosuppression.…”

Section: Clinical Presentation Of Lichtheimia Infectionsmentioning

confidence: 99%

Mucormycoses caused byLichtheimiaspecies

Schwartze

Jacobsen

2014

Mycoses

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SummaryMucormycoses are life-threatening infections with fungi from the order Mucorales (Mucoromycotina). Although mucormycoses are uncommon compared to other fungal infections, e.g. aspergillosis and candidiasis, the number of cases is increasing especially in immunocompromised patients. Lichtheimia (formerly Absidia) species represent the second to third most common cause of mucormycoses in Europe. This mini review presents current knowledge about taxonomy and clinical relevance of Lichtheimia species. In addition, clinical presentation and risk factors will be discussed. Proper animal infection models are essential for the understanding of the pathogenesis and the identification of virulence factors of fungal pathogens. To date, several animal models have been used to study Lichtheimia infection. A brief overview of the different models and the main conclusions from the infection experiments is summarised in this review.

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“…It is a saprotrophic fungus and can be found throughout the world . The phylum is highly resistant towards azoles and echinocandins and as a result fast identification of the aetiological agent, when zygomycetes are the cause, is of utmost importance . The current treatment of choice has through in vitro , in vivo and minimum inhibitory concentrations (MICs) studies shown to be a combination of Amphotericin B and Posaconazole .…”

Section: Discussionmentioning

confidence: 99%

“…Lichtheimia corymbifera is a rare cause of opportunistic infections and belongs to the phylum zygomycota. Zygomycete infections are often fatal, with a mortality rate of 54% and even in cases with a good prognosis any delay in diagnosis and treatment often leads to amputation of the infected limb .…”

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confidence: 99%

A non‐fatal case of invasive zygomycete (Lichtheimia corymbifera) infection in an allogeneic haematopoietic cell transplant recipient

Eickhardt

Braendstrup

Clasen‐Linde

et al. 2012

APMIS

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Post-transplant infections in allogeneic haematopoietic cell transplant (allo-HCT) recipients often have severe consequences. This is especially the case when dealing with zygomycete infections where the result is often fatal. A major problem when dealing with zygomycete infections is the need for an accurate and fast diagnosis as the phylum is highly resistant towards the conventional antifungals. We herein describe a non-fatal case of Lichtheimia corymbifera infection in an allo-HCT recipient.

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Lichtheimia corymbifera subcutaneous infection successfully treated with amphotericin B, early debridement, and vacuum-assisted closure

Cited by 15 publications

References 11 publications

Acute Lymphoblastic Leukemia with Malignant Hypercalcemia: A Case Report

Acute Lymphoblastic Leukemia with Malignant Hypercalcemia: A Case Report

Mucormycoses caused byLichtheimiaspecies

A non‐fatal case of invasive zygomycete (Lichtheimia corymbifera) infection in an allogeneic haematopoietic cell transplant recipient

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