LiClO4-Activated stereo- and regioselective alkylation of aldehydes

Asymmetric Acid-Catalyzed Meerwein−Ponndorf−Verley−Aldol Reactions of Enolizable Aldehydes

“…During our ongoing studies of the deployment of LiClO 4 in stereoselective C−C bond formation processes we have also demonstrated the successful execution of Prins reactions . These transformations were carried out in the presence of catalytic amounts of tartaric acid and tertiary alcohols.…”

LiClO4-Amine Mediated Direct Aldol Process

“…Recently, we published results obtained in a LiClO 4 mediated Prinstype reaction. 5 By reactions of tertiary alcohols with aldehydes in the presence of LiClO 4 and acids the corresponding diols and substituted tetrahydropyranoles could be isolated.…”