Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells

Gao, Feng; Li, Ming; Yu, Xinfang; Liu, Wenbin; Zhou, Li; Li, Wei

doi:10.1111/jcmm.16135

Cited by 23 publications

(25 citation statements)

References 69 publications

(98 reference statements)

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“…Licochalcone A plays a vital role in reversing the ectopic expression of key microRNA (miR-144-3p, miR-20a-5p, miR-29c-3p, let-7d-3p, and miR-328-3p) to elicit lung cancer chemopreventive activities both in vivo and in vitro [ 82 ]. In addition, licochalcone A has been reported to inhibit EGFR signaling and reduced the expression of Survivin protein in a cap-dependent translation manner to exhibit profound activity in mutated NSCLC cells [ 83 ].…”

Section: Natural Products As Monotherapy For the Treatment Of Lung Cancermentioning

confidence: 99%

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Yang

Wang

2021

Biomedicines

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As a public health emergency of international concern, the highly contagious coronavirus disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of billions of individuals. Lung cancer, a malignant tumor with the highest mortality rate, has brought significant challenges to both human health and economic development. Natural products may play a pivotal role in treating lung diseases. We reviewed published studies relating to natural products, used alone or in combination with US Food and Drug Administration-approved drugs, active against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and lung cancer from 1 January 2020 to 31 May 2021. A wide range of natural products can be considered promising anti-COVID-19 or anti-lung cancer agents have gained widespread attention, including natural products as monotherapy for the treatment of SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, and baicalein) or lung cancer (daurisoline, graveospene A, deguelin, and erianin) or in combination with FDA-approved anti-SARS-CoV-2 agents (cepharanthine plus nelfinavir, linoleic acid plus remdesivir) and anti-lung cancer agents (curcumin and cisplatin, celastrol and gefitinib). Natural products have demonstrated potential value and with the assistance of nanotechnology, combination drug therapies, and the codrug strategy, this “natural remedy” could serve as a starting point for further drug development in treating these lung diseases.

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Section: Natural Products As Monotherapy For the Treatment Of Lung Cancermentioning

confidence: 99%

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Yang

Wang

2021

Biomedicines

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“…Monaem et al obtained a series of tetrazole chalcones (Tables S1 and S2, compounds [173][174][175][176][177][178][179]. For the obtained compounds, cytotoxicity was evaluated by the MTT method on HCT116, PC3, and MCF-7 cell lines and on Vero B (African green monkey kidneys).…”

Section: Tetrazole Chalcone Derivativesmentioning

confidence: 99%

“…Farghali et al obtained thiazole chalcones (Tables S1 and S2, compounds [173][174][175][176][177][178]. The antiproliferative activity of the obtained compounds was determined on three cell lines (HepG2,A549, and MCF-7).…”

Section: Thiazole Chalcone Derivativesmentioning

confidence: 99%

“…Hydrogen bonds are formed between WT EGFR and licochalcone on Met793, Lys745, and Asp 855.Exon 19 deletion has the ability to change the shape of the pocket in which interaction with licochalcone is considered to occur, forming hydrogen bonds with Met793, Thr790, and Glu762. Data obtained by in silico analyses of LA are an important point for identification of new, selective EGFR inhibitors on different types of mutations [ 178 ].…”

Section: Anticancer Activitymentioning

confidence: 99%

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Anticancer Activity of Natural and Synthetic Chalcones

Constantinescu

Lungu²

2021

IJMS

103

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Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells. Resistance to treatment is theleading cause of the inefficiency of current standard therapies. Targeted therapies are the most effective due to the low number of side effects and low resistance. Among the small molecule natural compounds, flavonoids are of particular interest for theidentification of new anticancer agents. Chalcones are precursors to all flavonoids and have many biological activities. The anticancer activity of chalcones is due to the ability of these compounds to act on many targets. Natural chalcones, such as licochalcones, xanthohumol (XN), panduretin (PA), and loncocarpine, have been extensively studied and modulated. Modification of the basic structure of chalcones in order to obtain compounds with superior cytotoxic properties has been performed by modulating the aromatic residues, replacing aromatic residues with heterocycles, and obtaining hybrid molecules. A huge number of chalcone derivatives with residues such as diaryl ether, sulfonamide, and amine have been obtained, their presence being favorable for anticancer activity. Modification of the amino group in the structure of aminochalconesis always favorable for antitumor activity. This is why hybrid molecules of chalcones with different nitrogen hetercycles in the molecule have been obtained. From these, azoles (imidazole, oxazoles, tetrazoles, thiazoles, 1,2,3-triazoles, and 1,2,4-triazoles) are of particular importance for the identification of new anticancer agents.

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“…PTM is an important component of protein activity regulation. 39 , 40 , 41 , 42 Phosphorylation modification is the most common and most important PTM regulating the protein kinase and other protein activities. 43 Quantitative phosphoproteomics is widely used for proteomic stratification and drug target identification.…”

Section: Development Of Quantitative Proteomicsmentioning

confidence: 99%

Quantitative proteomics characterization of cancer biomarkers and treatment

Yang

Shi

Zhang

et al. 2021

Molecular Therapy - Oncolytics

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Cancer accounted for 16% of all death worldwide in 2018. Significant progress has been made in understanding tumor occurrence, progression, diagnosis, treatment, and prognosis at the molecular level. However, genomics changes cannot truly reflect the state of protein activity in the body due to the poor correlation between genes and proteins. Quantitative proteomics, capable of quantifying the relatively different protein abundance in cancer patients, has been increasingly adopted in cancer research. Quantitative proteomics has great application potentials, including cancer diagnosis, personalized therapeutic drug selection, real-time therapeutic effects and toxicity evaluation, prognosis and drug resistance evaluation, and new therapeutic target discovery. In this review, the development, testing samples, and detection methods of quantitative proteomics are introduced. The biomarkers identified by quantitative proteomics for clinical diagnosis, prognosis, and drug resistance are reviewed. The challenges and prospects of quantitative proteomics for personalized medicine are also discussed.

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Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells

Cited by 23 publications

References 69 publications

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Anticancer Activity of Natural and Synthetic Chalcones

Quantitative proteomics characterization of cancer biomarkers and treatment

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