Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells

Yuan, Luo‐Wei; Jiang, Xiaoming; Xu, Yan; Huang, Mu‐Yang; Chen, Yu‐Chi; Yu, Wei-Bang; Su, Min‐Xia; Ye, Zi-Han; Chen, Xiuping; Wang, Ying; Lu, Jin‐Jian

doi:10.1016/j.phymed.2020.153394

Cited by 35 publications

(31 citation statements)

References 31 publications

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“…Licochalcone A can significantly increase autophagic cytotoxicity (in both A549 and H460 cell lines) and downregulated the expression of c-IAP1, c-IAP2, XIAP, survivin, c-FLIPL, and RIP1, apoptosis-related proteins via inhibiting the activity of phosphorylated extracellular signal-regulated kinase (ERK) and autophagy [ 80 ]. In addition, licochalcone A has been reported to abolish the expression of programmed death ligand-1 (PD-L1) by increasing reactive oxygen species (ROS) levels in a time-dependent manner and interfering with protein translation in cancer cells [ 81 ]. Further, licochalcone A can inhibit PD-L1 translation likely through the inhibition of the phosphorylation of 4EBP1 and activation of the PERK-eIF2α signaling pathway [ 81 ].…”

Section: Natural Products As Monotherapy For the Treatment Of Lung Cancermentioning

confidence: 99%

“…In addition, licochalcone A has been reported to abolish the expression of programmed death ligand-1 (PD-L1) by increasing reactive oxygen species (ROS) levels in a time-dependent manner and interfering with protein translation in cancer cells [ 81 ]. Further, licochalcone A can inhibit PD-L1 translation likely through the inhibition of the phosphorylation of 4EBP1 and activation of the PERK-eIF2α signaling pathway [ 81 ]. Licochalcone A plays a vital role in reversing the ectopic expression of key microRNA (miR-144-3p, miR-20a-5p, miR-29c-3p, let-7d-3p, and miR-328-3p) to elicit lung cancer chemopreventive activities both in vivo and in vitro [ 82 ].…”

Section: Natural Products As Monotherapy For the Treatment Of Lung Cancermentioning

confidence: 99%

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Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Yang

Wang

2021

Biomedicines

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As a public health emergency of international concern, the highly contagious coronavirus disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of billions of individuals. Lung cancer, a malignant tumor with the highest mortality rate, has brought significant challenges to both human health and economic development. Natural products may play a pivotal role in treating lung diseases. We reviewed published studies relating to natural products, used alone or in combination with US Food and Drug Administration-approved drugs, active against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and lung cancer from 1 January 2020 to 31 May 2021. A wide range of natural products can be considered promising anti-COVID-19 or anti-lung cancer agents have gained widespread attention, including natural products as monotherapy for the treatment of SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, and baicalein) or lung cancer (daurisoline, graveospene A, deguelin, and erianin) or in combination with FDA-approved anti-SARS-CoV-2 agents (cepharanthine plus nelfinavir, linoleic acid plus remdesivir) and anti-lung cancer agents (curcumin and cisplatin, celastrol and gefitinib). Natural products have demonstrated potential value and with the assistance of nanotechnology, combination drug therapies, and the codrug strategy, this “natural remedy” could serve as a starting point for further drug development in treating these lung diseases.

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Section: Natural Products As Monotherapy For the Treatment Of Lung Cancermentioning

confidence: 99%

Section: Natural Products As Monotherapy For the Treatment Of Lung Cancermentioning

confidence: 99%

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Yang

Wang

2021

Biomedicines

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“…Monaem et al obtained a series of tetrazole chalcones (Tables S1 and S2, compounds [173][174][175][176][177][178][179]. For the obtained compounds, cytotoxicity was evaluated by the MTT method on HCT116, PC3, and MCF-7 cell lines and on Vero B (African green monkey kidneys).…”

Section: Tetrazole Chalcone Derivativesmentioning

confidence: 99%

“…Farghali et al obtained thiazole chalcones (Tables S1 and S2, compounds [173][174][175][176][177][178]. The antiproliferative activity of the obtained compounds was determined on three cell lines (HepG2,A549, and MCF-7).…”

Section: Thiazole Chalcone Derivativesmentioning

confidence: 99%

“…LA has low cytotoxicity on embryonic lung fibroblast cells. In addition, it has ability to inhibit tumor growth and attenuate cis -platinum-induced toxicity [ 173 ]. Mechanisms by which flavonoids act as anticancer agents include inhibition of Akt activity by suppressing hexokinase-2-mediated tumor glycolysis in gastric cancer, downregulation of metalloproteinase 2 expression and induction of apoptosis in oral cancer cells, increased capacity of miR-144-3p to induce stress in endoplasmic reticulum and induce apoptosis in human lung cells, reduced PI3K/Akt/mTor activation and decreased autophagy in breast cancer, blocking G2/M phase of cell cycle, repressing cell invasion by MEK/ERK and ADAM 9 signaling pathways in human glioma cells, and inducing caspase-dependent apoptosis in human liver cells [ 174 ].…”

Section: Anticancer Activitymentioning

confidence: 99%

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Anticancer Activity of Natural and Synthetic Chalcones

Constantinescu

Lungu²

2021

IJMS

103

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Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells. Resistance to treatment is theleading cause of the inefficiency of current standard therapies. Targeted therapies are the most effective due to the low number of side effects and low resistance. Among the small molecule natural compounds, flavonoids are of particular interest for theidentification of new anticancer agents. Chalcones are precursors to all flavonoids and have many biological activities. The anticancer activity of chalcones is due to the ability of these compounds to act on many targets. Natural chalcones, such as licochalcones, xanthohumol (XN), panduretin (PA), and loncocarpine, have been extensively studied and modulated. Modification of the basic structure of chalcones in order to obtain compounds with superior cytotoxic properties has been performed by modulating the aromatic residues, replacing aromatic residues with heterocycles, and obtaining hybrid molecules. A huge number of chalcone derivatives with residues such as diaryl ether, sulfonamide, and amine have been obtained, their presence being favorable for anticancer activity. Modification of the amino group in the structure of aminochalconesis always favorable for antitumor activity. This is why hybrid molecules of chalcones with different nitrogen hetercycles in the molecule have been obtained. From these, azoles (imidazole, oxazoles, tetrazoles, thiazoles, 1,2,3-triazoles, and 1,2,4-triazoles) are of particular importance for the identification of new anticancer agents.

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Resilience Activity of Glycyrrhiza glabra in Relation to Cancer: Chemistry and Mechanism

Dhingra,

Sharma,

Kumari

et al. 2023

Bioprospecting of Tropical Medicinal Plants

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Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells

Cited by 35 publications

References 31 publications

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Anticancer Activity of Natural and Synthetic Chalcones

Resilience Activity of Glycyrrhiza glabra in Relation to Cancer: Chemistry and Mechanism

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