Licochalcone A Prevents Adipocyte Differentiation and Lipogenesis via Suppression of Peroxisome Proliferator-Activated Receptor γ and Sterol Regulatory Element-Binding Protein Pathways

Quan, Hai-Yan; Baek, Nam In; Chung, Sung Hyun

doi:10.1021/jf2050763

Cited by 29 publications

(20 citation statements)

References 30 publications

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“…The anti-obesity properties of licochalcone A, a natural phenol also from the root of Glycyrrhiza glabra, were assessed in 3T3-L1 adipocytes and resulted in reduced lipid accumulation and down regulation of the expression of key adipogenic genes and receptors [198]. The analysis in high-fat diet induced obese mice confirmed the anti-obesity effect of licochalcone A by decreasing their body weight and plasma triglyceride, and cholesterol level [198].…”

Section: From Rootsmentioning

confidence: 86%

Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research

Castro¹,

Preto²,

Vasconcelos³

et al. 2016

CTMC

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Obesity is a global health threat. OECD reported that more than half (52%) of the adult population in the European Union is overweight or obese. Obesity and obesity-related co-morbidities have deep negative effects on morbidity, mortality, professional and personal quality of life. Healthcare costs represent a negative impact of this disease, with an associated economic cost of 100 billion US$ per year in the United States. The most prescribed drugs for obesity treatment worldwide are orlistat, and phentermine/topiramate extended release, while the major prescribed drug for the same disease in the US are exenatide and dapagliflozin. The so far developed drugs, targeting weight loss, have a long history of malignant secondary effects. There is still a lack of efficient and safe drugs to treat obesity and related metabolic complications since in many cases cure cannot be reached by bariatric surgery or healthy lifestyle habits. Terrestrial and aquatic organisms are a promising source of valuable, bioactive compounds, often with interest for human health. Some of the natural compounds or organisms have been used for centuries by humans as traditional medicine foods. In this review, we give insights into the adipose tissue function and development, and the progress in traditional anti-obesity pharmacotherapy. A major focus is to highlight the state of the art of natural compounds with anti-obesity properties and their potential as candidates for drug development; an overview is given about natural compounds derived from different marine animal sources, cyanobacteria, marine phytoplankton, fungus or plants.

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Section: From Rootsmentioning

confidence: 86%

Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research

Castro¹,

Preto²,

Vasconcelos³

et al. 2016

CTMC

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“…The results were relatively consistent with the results from normal adult mice that were fed a high-fat diet. 21,22) Concerning the expression of CYP species in the liver, the expression of CYP3A, CYP1A, CYP2C, and CYP2D in the mothers that consumed a high-fat diet during pregnancy was not different from that in the control group, but the expression of CYP2E in the HF group was increased compared to the control group (Fig. 3).…”

Section: The Effect Of High-fat Diet Consumption During Pregnancy On mentioning

confidence: 96%

Consumption of a High-Fat Diet during Pregnancy Changes the Expression of Cytochrome P450 in the Livers of Infant Male Mice

Tajima

Ikarashi

Okaniwa

et al. 2013

Biological & Pharmaceutical Bulletin

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It has been recently reported that the consumption of a high-fat diet during pregnancy exerts various effects on fetuses and newborn mice. The purpose of this study was to determine the effects of a high-fat diet during pregnancy on the expression of cytochrome P450 (CYP) in the livers of offspring. Mouse dams were fed a high-fat diet during pregnancy from the time of conception. After their birth, the newborn mice were fed a normal diet until 12 weeks of age. In the livers of the infant male mice that consumed a high-fat diet, the protein expression of CYP3A and CYP2C was decreased, and the protein expression of CYP1A and CYP2E was increased at 6 and 12 weeks of age. However, almost no changes were observed in the CYP proteins at 6 and 12 weeks of age in the livers of the infant female mice that consumed a high-fat diet. The amount of pregnane X receptor (PXR) translocated into the nucleus was reduced in the livers of infant male mice that consumed a high-fat diet. However, there was neither an increase in tumor necrosis factor-α or interleukin-1β nor a decrease in lithocholic acid. These data suggested that CYP3A and CYP2C might decrease as a result of the decrease in the amount of nuclear PXR in infant male mice that consumed a high-fat diet. The results of this study suggested that the consumption of a high-fat diet by pregnant mothers may be one explanation for individual differences in pharmacokinetics.Key words high-fat diet; cytochrome P450; pregnane X receptor; pharmacokinetics Studies have reported that consumption of a high-fat diet during pregnancy exerts various effects on offspring.1-4) For example, rats born to mothers that were given a high-fat diet during pregnancy showed an increased number of galaninproducing brain cells (galanin is an orexigenic peptide in the brain), which leads to obesity at 10 weeks of age.1) Additionally, the level of brain-derived neurotrophic factor in the brain decreases, which can lead to the development of neurodegenerative diseases such as Alzheimer's disease. 4)Cytochrome P450 (CYP) is major drug-metabolizing enzyme that is known to metabolize approximately 70% of the drugs used in clinical practice.5) The role of the CYP3A subfamily is important because approximately 50% of all drugs are metabolized by CYP3A. 5) In humans, the expression level of CYP3A accounts for more than 30% and 70% of total CYP protein expression in the liver and the intestine, respectively. 6)Therefore, changes in CYP3A expression and activity exert significant effects on drug therapy. 7-9) It has been reported that there are sex differences in the expression of CYP. For example, in mice, CYP2D9 and CYP4A12 are specifically expressed in males, and CYP2A4, CYP2B9, CYP3A41, and CYP3A44 are specifically expressed in females. 10-12)There have been many reports suggesting that the consumption of a high-fat diet differentially affects the expression and activity of CYP. 13,14) It has also been reported that obesity in mothers affects the expression of CYP1A1 in fetuses. 15) We have demonstrated th...

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“…Isoliquiritin apioside and isoliquiritigenin, as sources of pancreatic lipase (PL) inhibitors for preventing obesity, could lower the plasma total triglycerides and total cholesterol [111]. Licochalcone A had an inhibitory effect on adipocyte differentiation and lipogenesis via the downregulation of PPAR-c, CCAAT/enhancer binding protein α (C/EBPα), and sterol regulatory element-binding protein 1c (SREBP-1c) in 3T3-L1 preadipocytes [112]. And other results demonstrated that licochalcone A was effective to reduce obesity and could recover metabolic homeostasis by inducing adipocyte browning [113].…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Natural Chalcones in Chinese Materia Medica: Licorice

Wang

Liang

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Licorice is an important Chinese materia medica frequently used in clinical practice, which contains more than 20 triterpenoids and 300 flavonoids. Chalcone, one of the major classes of flavonoid, has a variety of biological activities and is widely distributed in nature. To date, about 42 chalcones have been isolated and identified from licorice. These chalcones play a pivotal role when licorice exerts its pharmacological effects. According to the research reports, these compounds have a wide range of biological activities, containing anticancer, anti-inflammatory, antimicrobial, antioxidative, antiviral, antidiabetic, antidepressive, hepatoprotective activities, and so on. This review aims to summarize structures and biological activities of chalcones from licorice. We hope that this work can provide a theoretical basis for the further studies of chalcones from licorice.

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Licochalcone A Prevents Adipocyte Differentiation and Lipogenesis via Suppression of Peroxisome Proliferator-Activated Receptor γ and Sterol Regulatory Element-Binding Protein Pathways

Cited by 29 publications

References 30 publications

Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research

Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research

Consumption of a High-Fat Diet during Pregnancy Changes the Expression of Cytochrome P450 in the Livers of Infant Male Mice

Natural Chalcones in Chinese Materia Medica: Licorice

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