Lidocaine and structure-related mexiletine induce similar contractility-enhancing effects in ischaemia–reperfusion injured equine intestinal smooth muscle in vitro

Tappenbeck, Karen; Hoppe, Susanne; Hopster, Klaus; Kietzmann, Manfred; Feige, Karsten; Huber, Korinna

doi:10.1016/j.tvjl.2012.11.011

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…Tappenbeck et al . () recently demonstrated that both lidocaine and mexiletine (structurally related to lidocaine) enhanced contractility of ischaemia‐reperfusion injured equine jejunum and reduced creatine kinase release. Similarly, certain clinical studies have supportive positive effects of lidocaine use in equine POI.…”

Section: Post Operative Ileusmentioning

confidence: 99%

Equine post operative ileus: A review of current thinking on pathophysiology and management

Hudson

Pirie

2014

Equine Veterinary Education

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Summary Equine post operative ileus (POI) is a serious post surgical complication in the horse, with a significant fatality rate. Despite the ongoing debate with regard to both the clinical definition of equine POI and the optimal management of this condition, there is increasing awareness and acceptance, supported by scientific research, that inflammation plays a key role in its pathophysiology. This review aims to outline the current thinking on the pathophysiology and management of this condition, with reference to the published literature on equine, rodent and human POI. Although studies conducted in other species are likely to provide an abundant source of information with potentially useful translational applications for the equine condition, such an approach needs to be cognisant of potential interspecies differences both in the pathogenesis of the condition and in basic gastrointestinal physiology.

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Section: Post Operative Ileusmentioning

confidence: 99%

Equine post operative ileus: A review of current thinking on pathophysiology and management

Hudson

Pirie

2014

Equine Veterinary Education

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“…Consequently, dexmedetomidine was elected to rule out the influence of any other anaesthetics. Any effect would be present in both groups and most likely be temporary, considering that rapid wash-out has been described in organ baths [ 65 ]. The measurement of dexmedetomidine levels in the intestinal tissue prior to the organ bath experiment or at the end of the in vitro experiment could have given more information on the relevance of this in vivo dexmedetomidine CRI.…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine Has Differential Effects on the Contractility of Equine Jejunal Smooth Muscle Layers In Vitro

Verhaar

Hoppe²,

Grages

et al. 2023

Animals

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α2 agonists are frequently used in horses with colic, even though they have been shown to inhibit gastrointestinal motility. The aim of this study was to determine the effect of dexmedetomidine on small intestinal in vitro contractility during different phases of ischaemia. Experimental segmental jejunal ischaemia was induced in 12 horses under general anaesthesia, and intestinal samples were taken pre-ischaemia and following ischaemia and reperfusion. Spontaneous and electrically evoked contractile activity of the circular and longitudinal smooth muscles were determined in each sample with and without the addition of dexmedetomidine. During a second experiment, tetrodotoxin was added to determine if the effect was neurogenic. We found that the circular smooth muscle (CSM) contractility was not affected by ischaemia, whereas the longitudinal smooth muscle (LSM) showed an increase in both spontaneous and induced contractile activity. The addition of dexmedetomidine caused a decrease in the spontaneous contractile activity of CSM, but an increase in that of LSM, which was not mediated by the enteric nervous system. During ischaemia, dexmedetomidine also mildly increased the electrically induced contractile activity in LSM. These results may indicate a stimulatory effect of dexmedetomidine on small intestinal contractility. However, the influence of dexmedetomidine administration on intestinal motility in vivo needs to be further investigated.

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“…In in vitro studies, it has been demonstrated that lidocaine enhances the contractility of intestinal smooth muscle (Nieto et al, 2000;Guschlbauer et al, 2010;Tappenbeck et al, 2013). On the other hand, lidocaine has been shown to decrease the duration of (postope-rative) ileus in clinical studies on horses suffering from colic (Malone et al, 2006;Torfs et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Cardiovasculaire, respiratoire, gastro-intestinale en gedragseffecten van intraveneuze lidocaïnetoediening bij gezonde paarden bij bewustzijn en evaluatie van de relatie met serumconcentraties van lidocaïne en mono-ethylglycinexylidide

Salciccia¹,

Arevalo²,

Maes³

et al. 2019

Vlaams Diergeneeskundig Tijdschrift

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This study aimed to evaluate the relationship between the serum concentrations of lidocaine/ monoethylglycinexylidide (MEGX) and their effects on several systems in horses. Five healthy, conscious horses received a two-hour placebo intravenous infusion followed by a two-hour lidocaine infusion (bolus of 1.3 mg/kg over ten minutes followed by a continuous rate infusion of 0.05 mg/kg/min). Lidocaine and MEGX serum concentrations were sampled every ten to fifteen minutes during the experiment, and the presence of muscle fasciculations and loss of balance as well as the respiratory, digestive and cardiovascular systems of the five horses were evaluated by means of different non-invasive methods. During the lidocaine infusion, the mean (± SD) lidocaine and MEGX concentrations were respectively 768.88 ± 93.32ng/ml and 163.08 ± 108.98 ng/ml. The infusion of lidocaine significantly influenced the presence of fasciculations, caused a statistically but non-clinically significant decrease of systolic and diastolic blood pressures, which were both correlated with lidocaine and MEGX serum concentrations, and it increased the duodenal contractions frequency, which was correlated with the serum lidocaine concentration. In this study, mild hypotensive and prokinetic effects of short-term lidocaine infusion were observed.

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Lidocaine and structure-related mexiletine induce similar contractility-enhancing effects in ischaemia–reperfusion injured equine intestinal smooth muscle in vitro

Cited by 7 publications

References 18 publications

Equine post operative ileus: A review of current thinking on pathophysiology and management

Equine post operative ileus: A review of current thinking on pathophysiology and management

Dexmedetomidine Has Differential Effects on the Contractility of Equine Jejunal Smooth Muscle Layers In Vitro

Cardiovasculaire, respiratoire, gastro-intestinale en gedragseffecten van intraveneuze lidocaïnetoediening bij gezonde paarden bij bewustzijn en evaluatie van de relatie met serumconcentraties van lidocaïne en mono-ethylglycinexylidide

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