Lidocaine+clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects

Brković, Božidar; Gardasevic, Milka; Roganović, Jelena; Jović, N; Todorović, Ljubomir; Stojić, Dragica Lj.

doi:10.1016/j.ijom.2007.07.019

Cited by 32 publications

(39 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However the diastolic blood pressure decreased slightly after 5 min of each of the drug administration and returned to baseline values within an hour of the injection and the mean change of the systolic and diastolic blood pressure after one hour from the baseline value was not significant statistically (p > 0.05). Similar findings were reflected in the previous studies of several authors including Malamed et al, [14], Brkovic et al, [31], Colombini et al, [32], Martinez et al, [33], Vasconcellos et al, [28]. However finding of Moore et al, [27] were contradictory where only A100 treatment group (receiving 4% articaine with 1:100,000 epinephrine) showed a statistically significant decrease in systolic blood pressure (2.6 mm Hg, p = 0.0153) at the completion of the testing session.…”

Section: Hemodynamic Parameterssupporting

confidence: 92%

Maxillary Posterior Teeth Removal Without Palatal Injection –Truth or Myth: A Dilemma for Oral Surgeons

Sharma

Aseri

et al. 2014

JCDR

View full text Add to dashboard Cite

Section: Hemodynamic Parameterssupporting

confidence: 92%

Maxillary Posterior Teeth Removal Without Palatal Injection –Truth or Myth: A Dilemma for Oral Surgeons

Sharma

Aseri

et al. 2014

JCDR

View full text Add to dashboard Cite

“…Santos et al [49] reported that transient increase or decrease in blood pressure and oxygen saturation were observed but they were neither clinically significant nor statistically significant. Several authors Malamed et al [8,9], Brkovic et al [18], Colombini et al [43], Martinez et al [52], Elad et al [55], Vasconcellos et al [56] were in accordance with our findings. On the contrary Moore et al [40] reported that only A100 treatment group showed a statistically significant decrease in systolic blood pressure at the completion of testing A100 decreased 2.6 mmHg, p = 0.0153).…”

Section: Blood Pressuresupporting

confidence: 92%

Efficacy of 4 % Articaine and 2 % Lidocaine: A clinical study

Kambalimath¹,

Dolas

Kambalimath

et al. 2012

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

Objectives This study was undertaken to compare the anesthetic properties of 4 % Articaine hydrochloride and 2 % Lidocaine both with 1:100,000 epinephrine for mandibular inferior alveolar nerve anesthesia. Materials and Methods Thirty healthy patients were included in this randomized double-blind clinical cross over study. Each subject received each test solution at different times. Inferior alveolar nerve block anesthesia was used for extraction of bilateral impacted mandibular third molar on different occassions. The time of onset of action, duration of anesthesia, efficacy of anesthesia, hemodynamic parameters and oxygen saturation were monitored during the procedure. A visual analog scale was used to assess pain during surgery, and thus subjectively evaluate the anesthetic efficacy of the two solutions. Results No statistically significant differences were seen in the onset and duration of anesthesia between the Articaine and Lidocaine solutions. Conclusions 4 % Articaine offers better clinical performance than 2 % Lidocaine, particularly in terms of latency and duration of the anesthetic effect. However, no statistically significant differences in anesthetic efficacy were recorded between the two solutions.

show abstract

“…However a significant reduction in heart Table 2 Free fraction of lidocaine in serum and tissues in the in vivo experiment Table 3 Percentage (%) of free lidocaine fraction in serum and tissues in the in vitro experiment rate and systolic blood pressure was observed in the lidocaine plus clonidine group, and a significant increase in heart rate was evident in the lidocaine plus epinephrine group 10 min after third molar surgery (16,17). On the other hand, it has been shown that mepivacaine, a compound similar to lidocaine, might modulate the contractility of the heart and vascular system (25).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, clonidine is applicable as an adjunct in epidural or spinal morphine treatment for cancer pain (15). It has also been proposed that the combination of lidocaine and clonidine could be useful in dental practice as a safe alternative to lidocaine and epinephrine mixture for intraoral infiltration and block anesthesia (16,17).…”

Section: Introductionmentioning

confidence: 99%

The influence of clonidine co-administration on the extent of lidocaine protein binding to rat serum and tissues

et al. 2011

View full text Add to dashboard Cite

Lidocaine is an amide local anesthetic and clonidine is an antihypertensive (α2-adrenergic agonist).The use of these two drugs in combination is recommended to enhance the analgesic effect of lidocaine. The aim of this study was to investigate the influence of clonidine co-administration on the extent of lidocaine binding to rat serum, heart and maxillofacial tissues in vivo and in vitro. Thirty-two Wistar rats received either lidocaine alone, or lidocaine and clonidine, in the masseter muscle, and were then sacrificed 15 or 30 min after treatment. Serum, masseter, mandible and heart samples were then isolated and incubated in 0.9% NaCl solution for 12 h at 8°C. The extent of binding in the incubation medium and the serum was estimated by ultrafiltration, and the free lidocaine fraction was determined by the radioscopic method in a β-counter. An in vitro procedure was also performed. Serum, heart, masseter and mandible samples were incubated at 37°C for 15 or 30 min in Ringer's solution containing either lidocaine or lidocaine and clonidine, and the samples were similarly subjected to ultrafiltration. The percentage binding of lidocaine was again estimated by the radioscopic method. Lidocaine levels were found to be increased by clonidine co-administration in vivo and the free lidocaine fraction was enhanced in vitro as well in the examined tissues, obviously through mechanisms related to protein binding alterations. (J Oral Sci 53, 61-66, 2011)

show abstract

Lidocaine+clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects

Cited by 32 publications

References 24 publications

Maxillary Posterior Teeth Removal Without Palatal Injection –Truth or Myth: A Dilemma for Oral Surgeons

Maxillary Posterior Teeth Removal Without Palatal Injection –Truth or Myth: A Dilemma for Oral Surgeons

Efficacy of 4 % Articaine and 2 % Lidocaine: A clinical study

The influence of clonidine co-administration on the extent of lidocaine protein binding to rat serum and tissues

Contact Info

Product

Resources

About