Lidocaine hydrochloride loaded isomaltulose microneedles for efficient local anesthesia of the skin

Dissolving microneedles for transdermal drug delivery in cancer immunotherapy

“…42,43 The commonly used materials to make dissolving microneedles can be divided into two groups: natural polymers and synthetic polymers. Natural polymers include carbohydrate compounds (hyaluronic acid, 44 maltose 45 /isomaltulose, 46 chitosan, 47 starch, 48 carboxymethyl cellulose, 49 trehalose 50 ) and proteins (silk protein, 51 gelatin, 52 and collagen 53 ). Synthetic polymers contain polyethylene pyrrolidone (PVP), 54 polyvinyl alcohol (PVA), 55 and polylactide glycolic acid (PLGA).…”

The Progress in the Application of Dissolving Microneedles in Biomedicine

“…This regulated Wnt/β-catenin, and the JAK2/STAT3 pathways reduced the expression of collagen I and III in HS and improved the therapeutic effect on HS. In addition to the aforementioned applications, microneedles are currently widely used in the treatment of other diseases, such as long-term contraception (Figure 6A) [37,[139][140][141], rheumatoid arthritis (Figure 6B) [142][143][144][145][146][147], weight loss (Figure 6C) [148][149][150][151], Alzheimer's disease [152][153][154], anesthesia [155][156][157][158], myocardial infarction (Figure 6D) [159][160][161][162], vaccine delivery [163][164][165][166], etc. We believe that microneedle technology will be Chiu et al [137] developed a microneedle (MN) formulation based on poly-γ-glutamate (γ-PGA) that not only protected EGCG from oxidation, but also acted as an immunomodulator to downregulate the helper T cell type 2 (Th2) immune response, effectively delivering EGCG into the skin to improve atopic dermatitis (AD) symptoms (Figure 5C).…”

“…In addition to the aforementioned applications, microneedles are currently widely used in the treatment of other diseases, such as long-term contraception (Figure 6A) [37,[139][140][141], rheumatoid arthritis (Figure 6B) [142][143][144][145][146][147], weight loss (Figure 6C) [148][149][150][151], Alzheimer's disease [152][153][154], anesthesia [155][156][157][158], myocardial infarction (Figure 6D) [159][160][161][162], vaccine delivery [163][164][165][166], etc. We believe that microneedle technology will be applied in more fields in the future to improve treatment efficiency for diseases and greatly facilitate patient use.…”