Lidocaine versus dexketoprofen in treatment of tension-type headache: A double-blind randomized controlled trial

Akbaş, İlker; Koçak, Abdullah Osman; Gür, Sultan Tuna Akgöl; Ahıskalıoğlu, Elif Oral; Doğruyol, Sinem; Dolanbay, Turgut; Demir, Mehmet; Çakır, Zeynep

doi:10.1016/j.ajem.2020.12.057

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…While Motamed et al ( 29 ) noted higher failure rates with IV lidocaine, Forouzan et al ( 31 ) found higher failure rates in the control group. Another study of Akbas et al ( 21 ) reported only change in pain scores at different time intervals. The authors noted significantly greater reduction of pain scores with IV lidocaine at 20, 30, 60, 90, and 120 min as compared to IV dexketoprofen.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of Intravenous Lidocaine for Pain Relief in the Emergency Department: A Systematic Review and Meta-Analysis

Zhong

Mao

et al. 2022

Front. Med.

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ObjectiveTo compare the efficacy of intravenous (IV) lidocaine with standard analgesics (NSAIDS, opioids) for pain control due to any cause in the emergency department.MethodsThe electronic databases of PubMed, Embase, ScienceDirect, CENTRAL, and Google Scholar were explored from 1st January 2000 to 30th March 2021 and randomized controlled trials (RCTs) comparing IV lidocaine with a control group of standard analgesics were included.ResultsTwelve RCTs including 1,351 patients were included. The cause of pain included abdominal pain, renal or biliary colic, traumatic pain, radicular low back pain, critical limb ischemia, migraine, tension-type headache, and pain of unknown origin. On pooled analysis, we found no statistically significant difference in pain scores between IV lidocaine and control group at 15 min (MD: −0.24 95% CI: −1.08, 0.61 I2 = 81% p = 0.59), 30 min (MD: −0.24 95% CI: −1.03, 0.55 I2 = 86% p = 0.55), 45 min (MD: 0.31 95% CI: −0.66, 1.29 I2 = 66% p = 0.53), and 60 min (MD: 0.59 95% CI: −0.26, 1.44 I2 = 75% p = 0.18). There was no statistically significant difference in the need for rescue analgesics between the two groups (OR: 1.45 95% CI: 0.82, 2.56 I2 = 41% p = 0.20), but on subgroup analysis, the need for rescue analgesics was significantly higher with IV lidocaine in studies on abdominal pain but not for musculoskeletal pain. On meta-analysis, there was no statistically significant difference in the incidence of side-effects between the two study groups (OR: 1.09 95% CI: 0.59, 2.02 I2 = 48% p = 0.78).ConclusionIV lidocaine can be considered as an alternative analgesic for pain control in the ED. However, its efficacy may not be higher than standard analgesics. Further RCTs with a large sample size are needed to corroborate the current conclusions.

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Section: Resultsmentioning

confidence: 99%

“…Twenty-four articles were analyzed by their full-text and 12 were excluded with reasons. A total of 12 RCTs fulfilled the inclusion criteria and were analyzed in this review (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). The agreement between the two reviewers on inclusion of the studies was high (kappa 0.9).…”

Section: Details Of Included Studiesmentioning

confidence: 99%

Efficacy of Intravenous Lidocaine for Pain Relief in the Emergency Department: A Systematic Review and Meta-Analysis

Zhong

Mao

et al. 2022

Front. Med.

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“…In studies comparing IV lidocaine and IV dexketoprofen trometamol in patients with migraine, the former was shown to provide a more effective analgesia than the latter. 22,23…”

Section: Discussionmentioning

confidence: 99%

Comparison of Intravenous Paracetamol, Dexketoprofen Trometamol, or Topical Lidocaine Use for Pain Relief in Scorpion Stings: A Placebo-Controlled, Randomized Study

Turgut

Yavuz

Gülaçtı

et al. 2022

Wilderness & Environmental Medicine

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Introduction-After a scorpion sting, patients commonly present to hospitals with pain. Our study sought to compare the analgesic efficacy of IV paracetamol, IV dexketoprofen trometamol, topical lidocaine, and placebo in patients reporting pain after presenting with a history of scorpion sting.Methods-This double-blind, randomized, placebo-controlled study was conducted in the emergency department of a tertiary hospital. Adult patients who presented with the complaint of pain after a scorpion sting and did not have systemic findings were randomly assigned to 1 of the following 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine, and placebo. The visual analog scale scores were measured at the time of presentation to the emergency department and at 30 and 60 min to determine the pain intensity.Results-The study included 106 patients, of whom 30 were in the paracetamol group, 26 in the dexketoprofen trometamol group, 25 in the topical lidocaine group, and 25 in the placebo group. We did not find a different analgesic effect among the groups in the first 30 min (P=0.185). IV paracetamol, dexketoprofen trometamol, and topical lidocaine did not show different analgesic effects in the first 60 min (P>0.05). IV paracetamol and dexketoprofen trometamol were found to provide a more effective analgesia than the placebo at 60 min (P<0.05). The analgesic effects of topical lidocaine and placebo did not differ (P=0.330).Conclusions-IV paracetamol and IV dexketoprofen trometamol provided analgesia in the first 60 min, similar to topical lidocaine but superior to placebo.

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“…M elatonin had also been validated to have the same effect as confirmed preventive drug Amitriptyline with more tolerable in the treatment of patients with migraine. Moreover, a study in 2021 showed that IV lidocaine is useful in the treatment of TTHs, which may reduce the use of NSAIDs to avoid its multiple side effects 56 …”

Section: Processes In the Acute Treatment And Prevention Of Headachementioning

confidence: 99%

“…Moreover, a study in 2021 showed that IV lidocaine is useful in the treatment of TTHs, which may reduce the use of NSAIDs to avoid its multiple side effects. 56…”

Section: Other Pharmacological Treatmentsmentioning

confidence: 99%

Breakthroughs on the clinical management of headache and questions that need to be solved

Liu

Yang

et al. 2021

Ibrain

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Headache is a common refractory disorder among adults, especially in females, which can lower the quality of life in patients and increase medical costs. Nearly 90% of people have been affected by headache disorders during their lifetime. The severe situation of headaches has drawn the attention of researchers in recent years. Although the mechanism of headache has not been fully understood by us, there are many effective preventive drugs and treatments available. This review is aimed to sum up the progress in clinical trials of headaches in the past 5 years.

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Lidocaine versus dexketoprofen in treatment of tension-type headache: A double-blind randomized controlled trial

Cited by 8 publications

References 25 publications

Efficacy of Intravenous Lidocaine for Pain Relief in the Emergency Department: A Systematic Review and Meta-Analysis

Efficacy of Intravenous Lidocaine for Pain Relief in the Emergency Department: A Systematic Review and Meta-Analysis

Comparison of Intravenous Paracetamol, Dexketoprofen Trometamol, or Topical Lidocaine Use for Pain Relief in Scorpion Stings: A Placebo-Controlled, Randomized Study

Breakthroughs on the clinical management of headache and questions that need to be solved

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